Functional RNA and small-molecule drug therapeutic complexes and nanoparticle delivery vehicles
A nanoparticle and small molecule technology, applied in the direction of non-active ingredients of polymer compounds, drug combinations, anti-tumor drugs, etc.
Inactive Publication Date: 2019-06-14
EOS BIOSCI INC
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- Description
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- Application Information
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Problems solved by technology
However, the toxicity of many anticancer agents presents an urgent need for effective low-dose therapies
Method used
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Embodiment approach 1
[0166] Embodiment 1. A composition comprising a functional RNA molecule complexed with a small molecule drug, wherein the functional RNA molecule regulates the expression of a target protein.
Embodiment approach 2
[0167] Embodiment 2. A composition comprising a functional RNA molecule comprising at least one complementary region into which a small molecule drug is embedded.
Embodiment approach 3
[0168] Embodiment 3. The composition according to embodiment 2, wherein the functional RNA molecule regulates the expression of the target protein.
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Abstract
Disclosed herein are therapeutic complexes comprising a small-molecule drug complexed with a functional RNA. Further disclosed herein are compositions comprising nanoparticles comprising a carrier polypeptide and a functional RNA molecule complexed with a small-molecule drug, wherein the carrier polypeptide comprises a cell -targeting segment, a cell-penetrating segment, and an oligonucleoti de-binding segment, along with methods of making and using such nanoparticles. Further described are methods of treating a subject with a cancer, comprising administering to the subject an effective amountof a composition comprising nanoparticles, the nanoparticles comprising a carrier polypeptide and a functional RNA molecule complexed with a small-molecule chemotherapeutic drug, wherein the carrierpolypeptide comprises a cell-targeting segment, a cell-penetrating segment, and an oligonucleotide-binding segment. Also described are pharmaceutical compositions, articles of manufacture, and kits comprising the described nanoparticles.
Description
[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Application No. 62 / 403,595, entitled "DRUG-DELIVERY NANOPARTICLESWITH RNA AND SMALL-MOLECULE CARGOS," filed October 3, 2016 priority interest, which is hereby incorporated by reference for all purposes. [0003] Sequence Listing Submitted as ASCII Text File [0004] The following submission as an ASCII text file is hereby incorporated by reference in its entirety: Sequence Listing in Computer Readable Format (CRF) (Filename 761542000840SEQLIST.txt, Date of Record: October 3, 2017, Size: 14KB). technical field [0005] The present invention relates to methods and nanoparticle compositions for the treatment of cancer. The invention further relates to nucleic acid-drug complexes. Background technique [0006] Current strategies for targeted therapy of tumors include antibody-targeted chemotherapeutics (i.e., immunoconjugates), targeted toxins, signal-blocking antibodies, and ant...
Claims
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IPC IPC(8): A61K31/7088A61K38/17A61K47/42A61P35/00
CPCA61K31/713A61K38/17A61K47/549A61K47/55A61K47/6455A61P35/00A61P37/04A61P43/00A61K47/42
Inventor O·K·哈法尔
Owner EOS BIOSCI INC