Absorbable bone wax and preparation method thereof

Abstract

The invention provides absorbable bone wax. The technical scheme is characterized in that the absorbable bone wax comprises a matrix material, an auxiliary material, an emulsifier and a hemostatic factor, wherein the matrix material is a mixture of any two or more of poly-DL-lactic acid, poly-L-lactic acid, polyglycolic acid, polycaprolactone, polyethylene glycol, polyvinyl alcohol, polyether diol, polyether triol, polylactic acid, poly(L-lactide-co-glycolide), a caprolactone-lactide copolymer and a caprolactone-glycolide copolymer; the auxiliary material is any one or a mixture of two of beta-tricalcium phosphate and hydroxyapatite; the emulsifier is any one or a mixture of two of sorbitan fatty acid ester and water soluble cellulose. On account of weight percentage wt%, the matrix material accounts for 20%-90%, the auxiliary material accounts for 10%-80%, and the emulsifier is 1%-20% of the total mass of the matrix material and the auxiliary material.

Description

Technical field [0001] The invention relates to a bone wax, in particular to an absorbable bone wax and a preparation method thereof. Background technique [0002] Clinically, the cancellous bone structure is loose and the blood supply is abundant, and the bleeding from the wound is mostly bleeding. The bleeding of cancellous bone wounds does not stop or it is difficult to completely stop the bleeding. The reason is that the bone wound has a loose tissue structure, abundant blood supply to form dense sinusoids, poor vasoconstriction in the tissue, platelet aggregation, and blood clots difficult to adhere to the bone wound. Bone wound bleeding is difficult to stop bleeding on its own by vasoconstriction, and it is also difficult to stop bleeding by conventional methods such as electrocoagulation, clamp, hemostatic gauze, gelatin sponge packing and so on. Bone wax is commonly used to stop bleeding in cancellous bone wounds. [0003] The working principle of bone wax is to physically...

AI Technical Summary

Problems solved by technology

At present, there are many clinical problems in the above-mentioned bone wax: first, the implantation of bone wax as a foreign body reduces the anti-infection ability of the tissue, which increases the risk of postoperative infection; second, it hinders the repair of bone wounds and forms local pain caused by foreign body granulomas , exudate and other symptoms; third, the bonding effect between beeswax and bone is not good, it is not easy to adhere to the bone surface, and it is easy to slip off during the operation

The main problem is that it has certain elasticity, poor ductility, and some unreacted monomers remain, which greatly stimulates human tissues.

The bone wax prepared by this me...

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