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Nano antibody and preparation method and application thereof

A nanobody and antibody technology, applied in the biological field, can solve problems such as the advent of antibody drugs, and achieve high stability, high water solubility, and high antigen binding effects

Active Publication Date: 2019-06-18
SHENZHEN HUADA GENE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, for ion channel targets, there is no mature antibody drug available so far

Method used

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  • Nano antibody and preparation method and application thereof
  • Nano antibody and preparation method and application thereof
  • Nano antibody and preparation method and application thereof

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Embodiment Construction

[0028] Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

[0029] It should be noted that the terms "first" and "second" are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity of indicated technical features. Thus, a feature defined as "first" and "second" may explicitly or implicitly include one or more of these features. Further, in the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0030] Nanobodies

[0031] In a first aspect of the invention, the...

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Abstract

The invention provides a nano antibody. As for the nano antibody, (1) an amino acid sequence shown in SEQ ID NO:1 is achieved; or (2) compared with the (1), the at least 70% identity, the at least 75%identity, the at least 80% identity, the at least 85% identity, the at least 90% identity, the at least 95% identity, and the at least 99% identity are achieved. According to the embodiments, the nano antibody is an antibody specifically targeting an ion channel TRPV3, the native conformation TRPV3 can be combined, and the nano antibody has the high water solubility, high tolerance, high stability, high antigen bondability, low immunogenicity, high tissue penetrating power, and high expressivity.

Description

technical field [0001] The present invention relates to the field of biotechnology, specifically, the present invention relates to nanobodies and their preparation methods and applications, more specifically, the present invention relates to nanobodies, isolated nucleic acids, nucleic acid constructs, expression vectors, host cells, pharmaceutical compositions, Use of nanobody in preparing medicine and method for preparing nanobody. Background technique [0002] Living cells are constantly carrying out metabolic activities, so they must constantly exchange substances with the surrounding environment, and ion channels on the cell membrane are one of the important ways for this kind of material exchange. Ion channels are a class of transmembrane proteins responsible for the specific transport of ions between the cell and the cell. By controlling the flow of ions, ion channels can rapidly regulate various cell signals in excitatory tissues, and slowly regulate cell proliferati...

Claims

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Application Information

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IPC IPC(8): C07K16/28C12N15/13A61K39/395A61P17/00A61P1/02
Inventor 刘楚新杨乃波任艳曹丽霞丁权黄谧王媚娘任哲邹婉婷
Owner SHENZHEN HUADA GENE INST
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