Unlock instant, AI-driven research and patent intelligence for your innovation.

Screening and application of urinary protein markers related to lung metastasis of early breast cancer

A technology of breast cancer and protein, applied in the field of clinical medicine, can solve the problem of ineffective metastasis of breast cancer

Active Publication Date: 2021-07-06
BEIJING NORMAL UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, the method of treating primary breast cancer is often used to treat metastatic breast cancer, which is often ineffective in controlling breast cancer metastasis (see Sharma R, Sharma R, Khaket TP, Dutta C, Chakraborty B, Mukherjee TK. Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1. Cell Oncol (Dordr). 2017; 40(3):199-208)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Screening and application of urinary protein markers related to lung metastasis of early breast cancer
  • Screening and application of urinary protein markers related to lung metastasis of early breast cancer
  • Screening and application of urinary protein markers related to lung metastasis of early breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Establishment of a Rat Model of Breast Cancer Lung Metastasis

[0028] The rat walker256 breast cancer lung metastases model is a classic animal model for studying the progression of breast cancer lung metastases, and is suitable for studying the pathophysiological and morphological changes during the progression of lung metastases. Use this animal model to simulate the process of breast cancer lung metastasis, and observe the overall changes of breast cancer lung metastasis from non-metastasis, early metastasis, metastatic progression and late metastasis. The pathological process and pathological characteristics are similar to those of human breast cancer lung metastasis. It has important guiding significance for diagnosing lung metastasis of breast cancer and monitoring the progress of breast cancer.

[0029] In this application, the method of annotating walker256 cells in the tail vein was used to prepare the animal model of lung metastasis of breast cance...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the screening of urine protein markers related to lung metastasis of early breast cancer and its application. Specifically, the present invention relates to a method for establishing an animal model for screening urine protein markers related to lung metastasis of early breast cancer, and urine protein markers related to lung metastasis of early breast cancer obtained by using the above-mentioned animal model established by the method of the present invention. Use of the protein marker and the reagent for detecting the urinary protein marker in the preparation of a kit for diagnosing lung metastasis of early breast cancer in a subject.

Description

technical field [0001] The present invention relates to clinical medicine. Specifically, it relates to urine protein markers associated with lung metastasis of human breast cancer. Specifically, the present invention relates to urine protein markers related to the diagnosis and / or monitoring of human breast cancer lung metastasis obtained by using a rat model of breast cancer lung metastasis and mass spectrometry proteomics technology, and uses thereof. Background technique [0002] Urine proteomics is of great significance in the study of disease markers. Biomarkers are monitorable changes associated with pathophysiological processes, which can be used to diagnose diseases, monitor disease processes, predict disease prognosis, and evaluate treatment effects, etc. [0003] As the product of blood filtered by the glomerulus, urine is an ideal source of disease markers: urine is simple and non-invasive, and can be collected for a long time, which is more conducive to observi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574G01N33/68G01N33/577
CPCG01N33/57488G01N33/577G01N33/6848
Inventor 高友鹤魏静
Owner BEIJING NORMAL UNIVERSITY