Simvastatin tablet capable of regulating fat comprehensively

A comprehensive technology for simvastatin, which is applied in the field of simvastatin tablets, can solve the problems of low bioavailability, and achieve the effects of simple preparation method, long-term action time, and improved reduction effect

Inactive Publication Date: 2019-07-12
贵州天安药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is: in order to solve the problem of low bioavailability of existing simvastatin tablets, further improve the disintegration rate and drug dissolution rate of the tablet, and provide a comprehensive lipid-lowering simvastatin tablet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, a comprehensive fat-regulating simvastatin tablet, comprising the following raw materials by weight: 10-15 parts of simvastatin, 15-20 parts of starch, 15-20 parts of low-substituted hydroxypropyl cellulose, 25-20 parts of ethanol 30 parts, 1-5 parts of magnesium stearate, 15-20 parts of microcrystalline cellulose;

[0026] A kind of comprehensive fat-regulating simvastatin tablet, specifically the following raw materials by weight: 15 parts of simvastatin, 15 parts of starch, 19 parts of low-substituted hydroxypropyl cellulose, 27 parts of ethanol, 4 parts of magnesium stearate, microcrystalline 20 parts of cellulose.

[0027] A comprehensive lipid-lowering simvastatin tablet, comprising the following production steps:

[0028] Step 1: batching, weigh the raw materials according to the above weight ratio;

[0029] Step 2: mixing, mixing the prepared raw materials;

[0030] Step 3: Granulating, granulating the mixed raw materials through a granulator; ...

Embodiment 2

[0037] Example 2, a simvastatin tablet for comprehensive lipid regulation, comprising the following raw materials by weight: 10-15 parts of simvastatin, 15-20 parts of starch, 15-20 parts of low-substituted hydroxypropyl cellulose, 25-25 parts of ethanol 30 parts, 1-5 parts of magnesium stearate, 15-20 parts of microcrystalline cellulose;

[0038] A kind of comprehensive fat-regulating simvastatin tablet, specifically the following raw materials by weight: 15 parts of simvastatin, 20 parts of starch, 15 parts of low-substituted hydroxypropyl cellulose, 25 parts of ethanol, 5 parts of magnesium stearate, microcrystalline 20 parts of cellulose.

[0039] A comprehensive lipid-lowering simvastatin tablet, comprising the following production steps:

[0040] Step 1: batching, weigh the raw materials according to the above weight ratio;

[0041] Step 2: Mixing, mixing the prepared raw materials, among which, 2 / 3 of the microcrystalline cellulose is used for mixing, 1 / 3 is reserved,...

Embodiment 3

[0050] Embodiment 3, a simvastatin tablet for comprehensive lipid regulation, comprising the following raw materials by weight: 10-15 parts of simvastatin, 15-20 parts of starch, 15-20 parts of low-substituted hydroxypropyl cellulose, 25-20 parts of ethanol 30 parts, 1-5 parts of magnesium stearate, 15-20 parts of microcrystalline cellulose;

[0051] A kind of comprehensive fat-regulating simvastatin tablet, specifically the following raw materials by weight: 12 parts of simvastatin, 20 parts of starch, 15 parts of low-substituted hydroxypropyl cellulose, 28 parts of ethanol, 5 parts of magnesium stearate, microcrystalline 20 parts of cellulose.

[0052] A comprehensive lipid-lowering simvastatin tablet, comprising the following production steps:

[0053] Step 1: batching, weigh the raw materials according to the above weight ratio;

[0054] Step 2: Mixing, mixing the prepared raw materials, among which, 2 / 3 of the microcrystalline cellulose is used for mixing, 1 / 3 is reserv...

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PUM

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Abstract

The invention discloses a simvastatin tablet capable of regulating fat comprehensively. The simvastatin tablet is prepared from, by weight, 10-15 parts of simvastatin, 15-20 parts of starch, 15-20 parts of low-substituted hydroxypropyl cellulose, 25-30 parts of ethanol, 1-5 parts of magnesium stearate and 15-20 parts of microcrystalline cellulose. The simvastatin tablet is specifically prepared from, by weight, 15 parts of simvastatin, 19 parts of starch, 17 parts of low-substituted hydroxypropyl cellulose, 25 parts of ethanol, 4 parts of magnesium stearate and 20 parts of microcrystalline cellulose, wherein the starch refers to pregelatinized starch, the ethanol refers to an ethanol water solution, the ethanol purity is 70%, ultraviolet rays are used for illumination and sterilization, and the inner package is an aluminum-plastic package. The simvastatin tablet is made into a tablet-shaped preparation suitable for oral application, the in-vitro dissolution rate and dissolution rate ofthe simvastatin are increased, the bioavailability is effectively improved, and the clinical application effect and compliance of patients are improved. Therefore, the treatment effect of medicine and the compliance of the patients are improved, and a good application prospect is obtained.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a simvastatin tablet for comprehensive lipid regulation. Background technique [0002] Simvastatin is a hydroxymethylglutaryl coenzyme, a methylated derivative of lovastatin, and is a semi-synthetic product. Similar to lovastatin, but with stronger inhibitory effect on HMG-CoA reductase. Simvastatin itself is inactive, and the hydrolyzate after oral absorption competitively inhibits the rate-limiting enzyme in the synthesis of cholesterol——HMG-CoA reductase, blocks the metabolic pathway of intracellular valonate, and makes intracellular cholesterol Synthesis decreases, thereby feedback stimulates the number and activity of low-level lipoprotein receptors on the surface of cell membranes (mainly liver cells), increases serum cholesterol clearance, and reduces levels. In addition, the concentrations of total triglycerides, very low-density lipoprotein cholesterol, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K31/366A61P3/06
CPCA61K9/0056A61K9/2054A61K9/2059A61K31/366A61P3/06
Inventor 王春艳吴邦华陶秀斌李玲
Owner 贵州天安药业股份有限公司
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