Micro-droplet generation device, system and method

A generation device and a technology of micro-droplets, which are applied in the field of measuring and distributing micro-liquids, can solve the problems of small volume errors and achieve the effects of controllable volume errors and precise size control

Active Publication Date: 2019-08-02
BEIJING ZHIYU BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on this, it is necessary to provide a micro-droplet generating device with a small volume error in view of the curren

Method used

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  • Micro-droplet generation device, system and method
  • Micro-droplet generation device, system and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] The microduct 100 is made of a non-rigid polypropylene material with a hardness of Shore D42. The inner diameter of the first opening 110 of the micropipe 100 is 150 microns, the outer diameter is 300 microns, and the length of the vibration radius is 6 cm. The vibration frequency of the rotary vibration mechanism 200 is 100 Hz, and the vibration amplitude voltage is 700 mVpp. The amplitude of the first opening 110 of the microchannel 100 is 0.1 mm.

[0125] The first opening 110 of the micropipe 100 is connected with the fluid drive mechanism 300 through the joint 230 and the capillary 310; Insert below the liquid surface of the second liquid 610 at an included angle of 30 degrees, so that the vertical distance from the center of the nozzle of the first opening 110 of the micropipe 100 to the liquid surface of the second liquid 610 is 1.5mm, and push the fluid drive mechanism 300 The syringe 350 in the cavity pushes the first liquid 130 in its chamber to the nozzle o...

Embodiment 2

[0127] The micropipe 100 is made of stainless steel. The first opening 110 has an inner diameter of 60 microns, an outer diameter of 200 microns, and a vibration radius of 5 cm. The vibration frequency of the rotary vibration mechanism 200 is 100 Hz, and the vibration amplitude voltage is 400 mVpp. The amplitude of the first opening 110 of the microchannel 100 was 1 mm.

[0128] The second opening 120 of the micropipe 100 is connected to the fluid drive mechanism 300 through the joint 230 and the capillary 310; the first opening 110 of the micropipe 100 is inserted into the second liquid at an angle of 90 degrees to the liquid surface of the second liquid 610 610 below the liquid level, so that the vertical distance from the nozzle center position of the first opening 110 of the microchannel 100 to the liquid level of the second liquid 610 is 1.5 mm, push the syringe 350 in the fluid drive mechanism 300 to move the first liquid in its cavity A liquid 130 is pushed to the nozz...

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PUM

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Abstract

The invention provides a micro-droplet generation device, system and method, and relates to the technical field of measurement and distribution of a trace liquid. The micro-droplet generation device comprises a micropipeline and a rotary vibration mechanism, wherein the micropipeline is provided with a first opening for outputting a first liquid, and the rotary vibration mechanism is used for driving the micropipeline to perform rotary vibration. The micro-droplet generation device drives the micropipeline by adopting the rotary vibration, and the size of emulsified micro-droplets produced when the liquid in the micropipeline is injected into another insoluble liquid is precise and controllable under the actions of high-frequency periodic inertia force and centrifugal force produced by therotary vibration, so that the volumetric error produced by massive droplets is controllable.

Description

technical field [0001] The invention relates to the technical field of measuring and distributing micro-liquids, in particular to a micro-droplet generation device, system and method based on micro-channels. Background technique [0002] At present, there is a wide demand for precise operation of trace liquids in medical clinical testing, nanomaterial preparation, food and environmental monitoring, biochemical analysis and other application fields. One of the core technologies of micro-liquid manipulation is to further divide microliter-level liquids into micro-reaction systems with nanoliter or even picoliter volumes. A main technical branch of micro-reaction system generation is the generation of emulsified micro-droplets. [0003] In recent years, a variety of microdroplet generation techniques have been reported in the literature, such as membrane emulsification, spray emulsification, microfluidic chip, micropipe injection / spraying, etc. The recent Chinese invention pa...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/502707B01L3/50273B01L2300/12B01L2400/0475B01L2400/0433
Inventor 李昂
Owner BEIJING ZHIYU BIOTECH LTD
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