The present invention proposes a method and use for stabilizing a simple
agglomerate for pH and salt and with adjustable size. In
phosphoric acid buffer solutions with different salt concentrations and pH values, the
polyacrylic acid hydroxypropyl group condensation body has specific stability; hydrophobic thermal response blocks are introduced into a hydroxypropyl
acrylate monomer through reversible addition-fragmentation
chain transfer polymerization to regulate and control the size of a condensation body, and a phase separation behavior is shown at different temperatures; a hydrophobic block without thermal response is introduced to regulate and control the size of the aggregate, and no thermal response behavior is shown. Continuous regulation and control of the size of the aggregate from the micron level to the nano level are achieved, and the requirements of different application scenes are met. The hydroxypropyl polyacrylate condensation body can be used for packaging various dyes and drugs; high-efficiency
enzyme protection is achieved, formed aggregates can protect
glucose oxidase, and the
retention rate of
enzyme activity reaches 85% or above
after treatment is conducted for 3 hours at 60 DEG C; as a micro-reactor for the reaction of generating p-nitrobenzaldehyde phenylhydrazone from p-nitrobenzaldehyde and
phenylhydrazine, the
reaction rate is greatly improved.