Optical waveguide sensing chip, preparation method thereof, and use

Abstract

A preparation method of an optical waveguide sensing chip comprises immersing a gold film substrate in an organic solution of mercapto silance to be processed, processing the processed gold film substrate by utilizing an acid solution, pasting a porous anodic aluminum oxide film to a surface of a gold film, immersing the aluminum oxide film pasted to the surface of the gold film in a mixed solution of cetyltrimethyl ammonium bromide (CTAB), water, ethyl alcohol, concentrated ammonia liquor and tetraethyl orthosilicate (TEOS) and standing for a period of time, and processing the processed product by utilizing an acid solution to remove the porous aluminum oxide film. The invention discloses the optical waveguide sensing chip and use of the optical waveguide sensing chip for non-labeled optical biological detection or heavy metal ion detection. The optical waveguide sensing chip is an optical waveguide sensing chip prepared by the method based on a nano-column array film. The optical waveguide sensing chip can be used to perform the high-sensitivity non-labeled optical biological detection or the high-sensitivity heavy metal ion detection.

Description

technical field [0001] The invention relates to a preparation method of an optical waveguide sensor chip, an optical waveguide sensor chip prepared by the method and its application, in particular to an optical waveguide sensor chip with a gold film as the base and a mesoporous silica nano-column array structure. A preparation method of a waveguide sensor chip, and the application of the chip in the detection of small molecules and heavy metal ions. Background technique [0002] Optical biosensors have the advantages of high detection sensitivity, large dynamic detection range, and low detection limit, and have been applied in many fields, including biomedical research, environmental monitoring, and medical diagnosis. Among optical biosensors, optical biosensors based on detection of refractive index changes are widely used. Among them, the surface plasmon resonance sensor is the most widely studied and applied in the non-labeled optical biosensor, and its sensitivity to th...

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Problems solved by technology

[0003] At present, the relatively mature nanostructure film materials used in optical waveguide sensors mainly include porous anodized aluminum oxide films, porous titanium dioxide films, mesoporous silica films, hydrogel films, and some materials filled with anodized aluminum oxide as templates. Nano-column (tube) array film, etc. However, the nano-structure film materials used in optical waveguide sensors prepared in the past have certain defects, such as poor acid-base stability of alumina, and the small pore size of mesoporous silica is limited in application. And the current methods of preparing nano-pillar array thin films are complicated, expensive, difficult to synthesize, etc.

In our previous invention, the silicon dioxide nanotube array film formed by cyclic sol-gel operation on the surface of anodized aluminum layer by layer of adsorbed silicon dioxide, the preparation process is complicated, and it is not easy to mass-produce

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