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Surface-drug-loading vertebroplasty dilatation balloon and preparation method thereof

A vertebroplasty and balloon technology, which is used in dilators, medical devices, medical science, etc., can solve the problem of single function of the balloon, reduce secondary fractures and refractures, have multiple functions, and prevent detachment from the position. Effect

Active Publication Date: 2019-08-20
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the deficiency that the balloons used in percutaneous vertebroplasty or percutaneous kyphoplasty have a single function, the present invention provides a drug-loaded vertebroplasty dilatation balloon on the surface of the dilation balloon. There is a drug-loaded film, and the drug-loaded film can remain in the body after the balloon is withdrawn, forming a shell that wraps the bone cement, which not only effectively releases the drug to the desired site, improves the efficiency of the drug, but also prevents the The role of bone cement out of position, multi-functional, improves the postoperative effect of percutaneous vertebroplasty and percutaneous kyphoplasty, especially suitable for the treatment of osteoporosis and related compression fractures

Method used

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  • Surface-drug-loading vertebroplasty dilatation balloon and preparation method thereof
  • Surface-drug-loading vertebroplasty dilatation balloon and preparation method thereof
  • Surface-drug-loading vertebroplasty dilatation balloon and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0050] A drug-loaded vertebroplasty dilation balloon (referred to as vertebroplasty dilation balloon), the drug-loaded vertebroplasty dilation balloon includes a balloon body, and a drug-loaded film is attached to the surface of the balloon body. The drug-loaded film is composed of at least two layers of drug-loaded coatings, wherein the first layer of drug-loaded coating is in direct contact with the balloon body, and the other layers of drug-loaded coatings are sequentially attached to the previous layer of drug-loaded coatings superior. figure 1 Schematic diagram of the structure of the vertebroplasty expansion balloon with two layers of drug-loaded coating, including the balloon body 2, the first layer of drug-loaded coating 3 and the second layer of drug-loaded coating 4, the first layer of drug-loaded coating 3 It is in direct contact with the balloon body 2 , and the second drug-loaded coating 4 is in direct contact with the first drug-loaded coating 3 .

[0051] Furth...

Embodiment 2

[0060] A drug-loaded vertebroplasty dilation balloon (referred to as vertebroplasty dilation balloon), which has the same structure as in Example 1, and further, the surface of the drug-loaded film is a non-smooth structure, and the surface is distributed with Protrusions or / and grooves, the protrusions or / and grooves are preferably evenly distributed on the surface of the drug-loaded film, and the shape of the protrusions or / and grooves can be any shape that can increase the specific surface area or / and frictional force, such as waves shape, sawtooth shape, spiral shape, needle shape, rod shape, figure shape, etc., and the shape can be at least one of circle, ellipse, regular polygon, non-regular polygon, irregular figure, etc. Such as image 3 As shown, rod-shaped protrusions are evenly distributed on the surface of the drug-loaded film, such as Figure 5 Said, the surface of the drug-loaded membrane is uniformly distributed with spiral protrusions extending axially of the ...

Embodiment 3

[0065] A drug-loaded vertebroplasty dilation balloon (referred to as vertebroplasty dilation balloon), which has the same structure as that of Example 1 or 2, further, the drug-loaded film is also equipped with a A through hole of the drug-loaded coating layer, the size of the through hole is on the order of millimeters. Such as Figure 6 As shown, when the bone cement is injected into the cavity formed by the drug-loaded membrane, the bone cement can seep out a small amount through the through-holes on the drug-loaded membrane before it is solidified, forming a structure similar to a protrusion, which plays a role in contact with the drug-loaded membrane. The same effect as the bump on it.

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Abstract

The present invention discloses a surface-drug-loading vertebroplasty dilatation balloon and a preparation method thereof. The surface-drug-loading vertebroplasty dilatation balloon comprises a balloon body, a drug-loading film is attached on surface of the balloon body, the drug-loading film is composed of at least two drug-loading coating layers, and the first drug-loading coating layer directlycontacting the balloon body is formed by electrospinning. The surface of the balloon body is provided with the drug-loading film, and the drug-loading film is composed of a plurality of the drug-loading coating layers, can be retained in body after the balloon is withdrawn, forms an outer shell enclosing bone cement, plays a function of effectively releasing the drugs at desired sites, improves function efficiency of the drugs, and also prevents the bone cement from detaching from positions. The vertebroplasty dilatation balloon has multiple functions, improves postoperative effects of percutaneous vertebroplasty and percutaneous kyphoplasty, and is especially suitable for treatments of osteoporosis and related compression fractures.

Description

technical field [0001] The invention relates to an expansion balloon for vertebroplasty, in particular to a surface-loaded vertebroplasty expansion balloon and a preparation method thereof, belonging to the technical field of medical devices for percutaneous vertebroplasty. Background technique [0002] With the aggravation of social aging, osteoporosis has become a common disease that endangers the health of the elderly. The fracture healing process caused by osteoporosis is slow, the risk of re-fracture is high, and the quality of life of patients is significantly affected. In 1984, French doctors first used percutaneous vertebroplasty (PVP) and percutaneous injection of bone cement methyl methacrylate (polymethyl-methacrylate, PMMA) to increase spinal stability, relieve pain, and prevent The vertebral body collapses further. Later, this technology was introduced to the United States, and on this basis, percutaneous kyphoplasty (PKP) was developed, which uses a dilation ...

Claims

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Application Information

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IPC IPC(8): A61M25/10A61M29/04A61B17/88
CPCA61B17/8816A61B2017/564A61M25/0021A61M25/0043A61M25/10A61M25/1027A61M29/02A61M2025/0008A61M2025/105A61M2210/1003A61M2210/005
Inventor 张海军孙刚田振凡侯文博周超尹玉霞鲁手涛刘光
Owner SHANDONG BRANDEN MEDICAL DEVICE
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