Constructing method of antibiosis medicament ceftiofur pharmacokinetic-pharmacodynamic synchronous model and application thereof

Abstract

The invention discloses a constructing method of an antibiosis medicament ceftiofur pharmacokinetic-pharmacodynamic synchronous model and application thereof. The method comprises the steps of detecting drug susceptibility of the antibiosis medicament ceftiofur to actinobacillus pleuropneumoniae, and obtaining an MIC distribution range; measuring free drug concentrations which are obtained in blood plasma samples which are obtained after drug application to healthy and disease model animals, and obtaining a drug concentration-time curve; fitting the pharmacokinetic parameter of the drug for obtaining a PK parameter; researching an antibiosis function of an antibiosis drug to pathogenic bacteria in in-vitro and semi-in vivo conditions, performing fitting for obtaining a PD parameter; establishing a semi-in vivo PK-PD model; and by means of a dosage calculating formula and Mlxplore software, obtaining a reasonable drug taking plan. The invention provides an optimizing method for an anti-drug-resistance drug taking plan of clinical ceftiofur, thereby alleviating generation and propagation of bacteria drug resistnace, and protecting and sustaining effectiveness of ceftiofur in clinic treatment.

Description

technical field [0001] The invention relates to the field of rational application of veterinary antibacterial drugs, in particular to a method for constructing a synchronous model of pharmacokinetics and drug effects of an antibacterial drug ceftiofur and its application. Background technique [0002] Porcine contagious pleuropneumonia (PCP), also known as necrotizing pleuropneumonia, is a highly contagious respiratory disease that can cause hemorrhage, suppurative and fibrous pleuropneumonia. It is endemic and can be transmitted by air and animal contact. Since there are as many as 16 serotypes of Actinobacillus pleuropneumoniae, and the dominant serotypes prevailing in different countries and regions are different, the infected animals may be infected with multiple serotypes. Pigs of all ages can be infected, especially pigs about 3 months old have the highest morbidity and mortality. Pathogens can be spread by the flow of air and contact between pigs. Its clinical sympt...

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Problems solved by technology

[0005] So far, there have been many reports on the research on the PK / PD binding model of antibacterial drugs, but many research contents have the following problems: (1) It only stays on the absorption, distribution, metabolism and elimination of antibacterial drugs in the body, ignoring the PK / PD binding model The causal relationship between antimicrobial drug dosing regimens and therapeutic effects; (2) For the clinical use of ceftiofur, most of them use the recommended dosage, and there is no specific treatment plan for Actinomyces pleuropneumoniae

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