pH fluorescence chemical sensor based on temperature-sensitive double hydrophilic block polymer, and synthesis method and application thereof

A block polymer, chemical sensor technology, applied in the field of chemical fluorescent materials, can solve the problems of easy breakage, difficult miniaturization, and high impedance

Active Publication Date: 2019-09-13
山东科建检测服务有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The rapid and accurate determination of the pH value in a solution is of great research significance to many fields such as chemistry, medicine, biology, agriculture and environmental science. However, most of the existing pH measurement methods are electrochemical

Method used

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  • pH fluorescence chemical sensor based on temperature-sensitive double hydrophilic block polymer, and synthesis method and application thereof
  • pH fluorescence chemical sensor based on temperature-sensitive double hydrophilic block polymer, and synthesis method and application thereof
  • pH fluorescence chemical sensor based on temperature-sensitive double hydrophilic block polymer, and synthesis method and application thereof

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Embodiment 1

[0052] Embodiment 1: PEG 113 -b-P(NIPAM-co-RhHHMa) 65 The preparation method comprises the following steps;

[0053] Step 1, preparation and characterization of the acidic recognition motif RhHHMa;

[0054] Add rhodamine B hydrazide (9.86g, 0.02mol) and p-hydroxybenzaldehyde (2.44g, 0.02mol) into (80.00mL), stir at 70.0°C for 1h, cool and crystallize to obtain the crude product, and The crude product was recrystallized 3 times in ethanol, and the product RhSA was a white solid (10.86g, yield: 88.0%);

[0055] RhSA (4.00g, 15.68mmol) and triethylamine (1.58g, 15.68mmol) were dissolved in dichloromethane (60.00mL), and methacryloyl chloride (1.62g, 15.68mmol) was added dropwise at 0.0°C, then Reflux reaction at 25.0°C for 4h, separate the organic layer, wash with saturated aqueous sodium carbonate solution 3 times, remove the solvent to obtain the crude product and recrystallize 3 times in acetonitrile, the product is a purple solid (6.86g, yield: 75.0%) .

[0056] 1 H NMR...

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Abstract

The invention discloses a pH fluorescence chemical sensor based on a temperature-sensitive double hydrophilic block polymer, and a synthesis method and application thereof, belonging to the technicalfield of chemical fluorescent materials. The pH fluorescence chemical sensor PEG<113>-b-P(NIPAM-co-RhHHMa)<65> based on the temperature-sensitive double hydrophilic block polymer is synthesized in theinvention, and an acid recognition motif RhHHMa is labeled in the temperature-sensitive block of the sensor. The pH fluorescence chemical sensor is a multifunctional fluorescent chemical sensor withpH response and temperature response, and has the characteristics of excellent water solubility, biocompatibility, high sensitivity, etc. Moreover, the pH fluorescence chemical sensor can self-assemble to form an aggregate with P(NIPAM-co-RhHHMa)<65> as a core, and the pH response motif RhHHMa is embedded in the hydrophobic core, so the quantum yield of fluorescent elements is increased, which enables the amplification of signals to be realized.

Description

technical field [0001] The invention belongs to the technical field of chemical fluorescent materials, and in particular relates to a pH fluorescent chemical sensor and its synthesis method and application. Background technique [0002] The pH value is one of the most important physical and chemical parameters of an aqueous solution. All natural phenomena, chemical changes and production processes involving water and solutions are related to pH. The rapid and accurate determination of the pH value in a solution is of great research significance to many fields such as chemistry, medicine, biology, agriculture and environmental science. However, most of the existing pH measurement methods are electrochemical detection, and most of them have high impedance. , Difficult to miniaturize, easy to break, low sensitivity, limited measurement range, "sodium error" and "acid error" and other defects limit its application in intracellular pH detection and cell imaging research. [0003...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F220/54G01N21/64
CPCC08F293/005G01N21/643G01N2021/6432C08F220/54
Inventor 刘晓云安宝东李文龙高少妮曾凡涛王杰飞杨秀丽阎钼琳
Owner 山东科建检测服务有限公司
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