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Cyclic snoRNA biomarker used for diagnosing renal clear cell carcinoma, kit and applications

A technology of renal clear cell carcinoma and biomarkers, applied in biochemical equipment and methods, DNA/RNA fragments, recombinant DNA technology, etc., can solve problems such as poor prognosis, achieve high sensitivity, save time, reduce damage and The effect of medical costs

Active Publication Date: 2019-09-13
中国医科大学
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Problems solved by technology

Kidney cancer patients may not have any signs or symptoms in the early stages of the disease, after diagnosis, the survival rate is generally 5 years, but the overall prognosis is poor, especially for patients with high-grade renal cell carcinoma

Method used

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  • Cyclic snoRNA biomarker used for diagnosing renal clear cell carcinoma, kit and applications
  • Cyclic snoRNA biomarker used for diagnosing renal clear cell carcinoma, kit and applications
  • Cyclic snoRNA biomarker used for diagnosing renal clear cell carcinoma, kit and applications

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Embodiment 1

[0043] Example 1 The method of the present invention for obtaining biomarkers.

[0044] The snoRNA-seq data of 530 clear cell renal cell carcinoma tumor tissues and 72 corresponding paracancerous tissues were downloaded from the TCGA database (https: / / cancergenome.nih.gov / ), and the expression value data of snoRNA were transformed by log2 to make Its standardization uses the edger package to screen the snoRNAs differentially expressed between cancer tissues and para-cancerous tissues, picks 300 patients as the test data set, and the other 230 patients as the verification data set, and then performs single-factor analysis of the differentially expressed snoRNAs in the test data set. Multivariate cox regression analysis finally screened 6 snoRNAs combined as independent risk factors for patients with clear cell renal cell carcinoma, which can be used as prognostic markers for clear cell renal cell carcinoma. A risk model was constructed based on the risk coefficient of each snoR...

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Abstract

The invention belongs to the field of biological detection, and specifically relates to a cyclic snoRNA biomarker used for diagnosing renal clear cell carcinoma, a kit and applications. The biomarkerconsists of the following cyclic snoRNA: SNORA2, SNORD12B, SNORA59B, SNORA70B, SNORD93 and SNORD116-2. The snoRNA that can obviously influence the lifetime of renal clear cell carcinoma patients can be screened, and differential expression and diagnosis capabilities can be verified in tissues and serum; and the biomarker can be effectively used for the diagnosis and prognosis of renal clear cell carcinoma, and the development and utilization of the biomarker can provide a novel direction for the diagnosis of tumor and other diseases and further treatment.

Description

technical field [0001] The invention belongs to the field of biological detection, and in particular relates to a circulating snoRNA biomarker for the diagnosis of renal clear cell carcinoma, a kit and its application. Background technique [0002] Kidney cancer, also known as renal cell carcinoma, ranks second among all types of urinary system malignancies according to epidemiological statistics. The incidence rate is slightly lower than that of bladder cancer, accounting for 90%-95% of all malignant tumors of the kidney. Its incidence ranks 7th and 10th among common malignant tumors in men and women, respectively, accounting for 3.7% of all new cancers. The incidence ratio of male to female usually increases with age, and the age of onset of most patients is over 50 years old, reaching a peak at 60-70 years old. [0003] Renal cell carcinoma mainly includes the following three pathological types, among which clear cell carcinoma (ccRCC) is the pathological type with the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/113
CPCC12Q1/6886C12Q2600/158C12Q2600/178C12Q2600/166C12Q2600/118
Inventor 何苗颜媛媛赵燕云魏敏杰
Owner 中国医科大学
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