Cyclic snoRNA biomarker used for diagnosing renal clear cell carcinoma, kit and applications

A technology of renal clear cell carcinoma and biomarkers, applied in biochemical equipment and methods, DNA/RNA fragments, recombinant DNA technology, etc., can solve problems such as poor prognosis, achieve high sensitivity, save time, reduce damage and The effect of medical costs
CN110229912AActive Publication Date: 2019-09-13中国医科大学
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
中国医科大学
Publication Date
2019-09-13

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Abstract

The invention belongs to the field of biological detection, and specifically relates to a cyclic snoRNA biomarker used for diagnosing renal clear cell carcinoma, a kit and applications. The biomarkerconsists of the following cyclic snoRNA: SNORA2, SNORD12B, SNORA59B, SNORA70B, SNORD93 and SNORD116-2. The snoRNA that can obviously influence the lifetime of renal clear cell carcinoma patients can be screened, and differential expression and diagnosis capabilities can be verified in tissues and serum; and the biomarker can be effectively used for the diagnosis and prognosis of renal clear cell carcinoma, and the development and utilization of the biomarker can provide a novel direction for the diagnosis of tumor and other diseases and further treatment.
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Description

technical field

[0001] The invention belongs to the field of biological detection, and in particular relates to a circulating snoRNA biomarker for the diagnosis of renal clear cell carcinoma, a kit and its application. Background technique

[0002] Kidney cancer, also known as renal cell carcinoma, ranks second among all types of urinary system malignancies according to epidemiological statistics. The incidence rate is slightly lower than that of bladder cancer, accounting for 90%-95% of all malignant tumors of the kidney. Its incidence ranks 7th and 10th among common malignant tumors in men and women, respectively, accounting for 3.7% of all new cancers. The incidence ratio of male to female usually increases with age, and the age of onset of most patients is over 50 years old, reaching a peak at 60-70 years old.

[0003] Renal cell carcinoma mainly includes the following three pathological types, among which clear cell carcinoma (ccRCC) is the pathological type with the ...

Claims

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