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Skin preparation for external use for hair growth

A technology of skin external preparation, saponin, which is applied in the field of skin external preparation for hair growth, can solve the problems of dangerous side effects, unclear effect, and sperm reduction, and achieve the effect of less stimulation, excellent hair growth effect and significant effect

Inactive Publication Date: 2019-10-22
NIL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Finasteride can improve AGA with a high probability, but there will be side effects of hyposexuality such as loss of libido, erectile dysfunction, and sperm reduction, and it has no effect on hair loss caused by mechanisms other than AGA
In addition, finasteride has no effect on women, not only that, but there is even the possibility of dangerous side effects
[0005] Patent Document 3 describes that t-flavanone has a hair growth effect and is also commercialized, but its effect is not clear

Method used

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  • Skin preparation for external use for hair growth
  • Skin preparation for external use for hair growth
  • Skin preparation for external use for hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Hereinafter, although an Example demonstrates this invention more concretely, this invention is not limited to the following Example.

[0054] In addition, the Quillaja saponin content of Quillaja saponins extracts shown below was determined by either of the following two methods: quantification of the four major Quillaja saponins using reversed-phase high-performance liquid chromatography (RP-HPLC), and The method (references: J.Sci.Food Agric., 80, 2063-2068 (2000)) using its total amount as the content of Quillaja saponins, or, use RP-HPLC to by making Quinaja extract partial hydrolysis The "partially hydrolyzed saponin" obtained as the main product is quantified and multiplied by the coefficient (1.67) converted to glycosides to determine the content of Quillaja saponin (refer to the 7th edition of the Japanese Food Additives Regulations ( D-438 "Quillaja extract" in 1997).

[0055] In addition, the smilax saponin (yucca saponin) content of the yucca extract shown ...

Embodiment 1～31、 comparative example 1～6

[0056] [Examples 1-31, Comparative Examples 1-6] -Hair growth test using shaved mice-

[0057] (1) Preparation of skin external preparation for hair growth

[0058] Sample solutions of Examples and Comparative Examples were prepared according to the following compositions.

[0059] ・A composition containing an active ingredient The active ingredient becomes the amount (mass %) of the addition amount shown in Table 1

[0060] ・Propylene glycol 5% by mass

[0061] ・Water Adjusted so that the total amount becomes 100% by mass

[0062] The following four commercially available compositions containing Quillaja saponin were used, and the composition was added such that the active ingredient (Saponilla saponin) was added in the amount shown in Table 1.

[0063] 1) Quillajanin D-100 (Seller: Maruzen Pharmaceutical Co., Ltd.)

[0064] Quillaja extract: 25% by mass (equivalent to 16% by mass of Quillaja saponin)

[0065] Propylene glycol: 15% by mass,

[0066] Water: 60% by mass ...

Embodiment 32～37

[0101] [Examples 32-37] Combined use effect of the saponin of the present invention and a known hair restorer

[0102] The effects of combined use of saponin and smilax saponin, which are the saponins of the present invention, with known hair restorers were investigated. Specifically, using Quillajanin D-100 and Sarakeep ALS, saponins or smilax saponins as active ingredients were mixed with known hair restorers according to the ratio shown in Table 2. The hair growth test was carried out in the same way as described in ~31. Table 2 shows the results together with the results of Examples 7 and 21.

[0103] [Table 2]

[0104]

[0105] As can be seen from the results in Table 2, when saponins or smilax saponins are used in combination with known hair growth agents, the improvement of the hair growth effect brought about by the combined use can be observed. However, when finasteride is used as an oral drug, the enhancement of the hair growth effect by combined use is lacking...

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Abstract

To provide a safe skin preparation for external use for hair growth which can be used regardless of gender and has an excellent hair growth effect. This skin preparation for external use for hair growth is characterized by containing at least one of Quillaja saponin and a steroid saponin as an active ingredient. Preferably, the steroid saponin is at least one selected from the group consisting ofSarsasaponin, Timosaponin, Digitalis saponin, Dioscorea japonica saponin, and Ophiopogon saponin. More preferably, the steroid saponin is Sarsasaponin.

Description

[technical field] [0001] The present invention relates to an external skin preparation for hair growth that can exhibit an excellent hair growth effect. [Background technique] [0002] Conventionally, various hair growth and growth agents have been proposed for hair thinning and hair loss accompanying aging (aging). There are also many commercially available pharmaceuticals, for example, minoxidil, finasteride, etc. (Patent Documents 1 to 2). In addition, in recent years, hair growth and hair growth agents derived from natural products have been developed in order to reflect health intentions (Patent Documents 3 to 6). [0003] Patent Document 1 describes that minoxidil has a hair growth effect. Minoxidil is a drug developed as an oral drug for high blood pressure, but it is currently used mainly for its side effect of thickening hair instead of its original effect. However, it originally has a vasodilator effect, and there is a risk of severe symptoms if taken in large a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61Q7/00
CPCA61K8/60A61Q7/00
Inventor 佐藤幸蔵佐藤忠久小岛哲郎
Owner NIL CO LTD
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