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System and method for drug interaction prediction

A technology for drugs and prescription drugs, applied in the field of possible systems, which can solve the problems of inefficiency and neglect of DDI systems

Inactive Publication Date: 2019-10-25
MEDAWARE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because of the problems mentioned earlier, the DDI system is still considered inefficient and ignored by many physicians and pharmacists until now.

Method used

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  • System and method for drug interaction prediction
  • System and method for drug interaction prediction
  • System and method for drug interaction prediction

Examples

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example

[0066] The invention will now be illustrated in a non-limiting manner with reference to the following examples in conjunction with the above description.

[0067] Co-prescribing spironolactone and trimethoprim

[0068] Standard DDI systems (eg ePocrates, MicroMedex, FDB, etc.) classify spironolactone and trimethoprim as "serious interactions". Extensive medical record examination by the inventors, however, revealed that this combination is often co-prescribed to patients with heart failure who require antibiotic therapy.

[0069] By mining the patient's EMR history and classifying drug prescriptions and co-prescriptions based on parameters such as diagnosis, disorder, indication (using the machine learning and probability equations described herein), the system can identify the specific DDI alert as and need Antibiotic-treated heart failure patients were less associated. Thus, when a subject diagnosed with heart failure and a bacterial infection is prescribed spironolactone ...

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Abstract

A system for drug interaction alerts and a method using same are provided. The system includes a computing platform configured for obtaining prescribing history for each of a drug A and a drug B and for drug A and drug B from medical records of a patient cohort. The system is further configured for determining a statistical probability for co-prescribing drug A and drug B versus a product of the statistical probability for prescribing drug A and the statistical probability for prescribing drug B, under different clinical contexts. This probability is then used to indicate a likelihood of druginteraction in a subject.

Description

technical field [0001] The present invention relates to a system and method for evaluating the likelihood of prescribing a drug combination to a subject, and more particularly to a system that provides pharmacists and physicians with more precise and specific information on the appropriateness of a drug combination to be used. Background technique [0002] Drug-drug interactions (DDIs) are a significant cause of patient morbidity and mortality, and can substantially increase hospitalization costs. [0003] Commercial software programs designed to assist pharmacists during prescription processing and physicians during prescribing have included DDI alerts for many years. However, the large number of false alerts issued by these systems cause user desensitization and alert fatigue, which leads pharmacists and physicians to ignore true alerts in many cases. [0004] Because of these limitations, currently used DDI systems have not achieved the desired goals. Attempts to addres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F16/903G06Q30/02G16H10/60G16H70/40G16H70/60
CPCG06Q30/02G16H50/70G16H70/60G16H70/40G16H20/10G06F16/2462G16H50/20G16H10/60G06F16/2457G06F17/18
Inventor 埃坦·伊斯拉埃尔
Owner MEDAWARE