A degradable polymer microsphere with surface pits and its preparation method and application

Abstract

The invention discloses a degradable polymer microsphere with surface pits and its preparation method and application. The preparation method comprises the following steps: dissolving the degradable polymer substance in an organic solvent to obtain a degradable polymer solution; In the aqueous solution of the agent, magnetically stir the upper part of the solution, then add magnetic solid particles, and then start to magnetically stir the lower part of the solution to gradually form microspheres; after the microspheres are solidified, stop stirring, and magnetic solid particles and embedded The microspheres with magnetic solid particles are separated; the processed microspheres which are not embedded and not coated with magnetic particles are cleaned and dried. The method is simple and feasible, the raw materials are easy to obtain, the cost is low, and it is easy to realize industrial production; the prepared microspheres not only have good biocompatibility and degradability, but also have surface pits suitable for cell adhesion, which can be used for tissue defects repair and reconstruction.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a degradable polymer microsphere with pits on the surface and a preparation method and application thereof. Background technique [0002] Polymer microspheres usually refer to polymer aggregates with diameters ranging from nanometers to micrometers and spherical shapes. As a new type of functional material, polymer microspheres have broad application prospects in many fields. In recent years, polymer microspheres have achieved good results in many fields such as bioengineering, medicine, environment, food and functional materials. At present, the materials used in microspheres are mainly divided into inorganic materials, natural polymer materials and synthetic polymer materials. According to the degradation performance, it can be divided into degradable materials and non-degradable materials. Among them, artificially synthesized degradable polymer materials can design their bi...

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Problems solved by technology

However, the microspheres prepared by the above-mentioned prior art generally have the following problems: 1) There are many components, and the performance evolution during application is difficult to predict; 2) Porous microspheres are prepared instead of surface pit microspheres, and the internal structure of the microspheres changes. It has an unpredictable impact on its degradation rate; 3) The preparation process is complex and difficult to industrialize

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