Degradable polymer microspheres with surface pits and preparation method and application thereof

Abstract

The invention discloses degradable polymer microspheres with surface pits and a preparation method and application thereof. The preparation method comprises the following steps that degradable polymersubstances are dissolved in an organic solvent to obtain a degradable polymer solution; the polymer solution is added into an aqueous solution containing a surfactant, the upper part of the solutionis magnetically stirred, then magnetic solid particles are added, and the lower part of the solution is then magnetically stirred to gradually form microspheres; after the microspheres are solidified,stirring is stopped, and a magnetic field is used for separating the magnetic solid particles from the microspheres with the magnetic solid particles embedded; and after the treated microspheres without embedded and wrapping magnetic particles are cleaned and dried, the degradable polymer microspheres with the surface pits are obtained. According to the method, a technology is simple and feasible, the raw materials are easy to obtain, the cost is low, and industrialized production can be easily achieved; the prepared microspheres have good biocompatibility and degradability and are provided with the surface pits suitable for cell adhesion, and thus the microspheres can be used for repairing and rebuilding defected tissue.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a degradable polymer microsphere with pits on the surface and a preparation method and application thereof. Background technique [0002] Polymer microspheres usually refer to polymer aggregates with diameters ranging from nanometers to micrometers and spherical shapes. As a new type of functional material, polymer microspheres have broad application prospects in many fields. In recent years, polymer microspheres have achieved good results in many fields such as bioengineering, medicine, environment, food and functional materials. At present, the materials used in microspheres are mainly divided into inorganic materials, natural polymer materials and synthetic polymer materials. According to the degradation performance, it can be divided into degradable materials and non-degradable materials. Among them, artificially synthesized degradable polymer materials can design their bi...

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Problems solved by technology

However, the microspheres prepared by the above-mentioned prior art generally have the following problems: 1) There are many components, and the performance evolution during application is difficult to predict; 2) Porous microspheres are prepared instead of surface pit microspheres, and the internal structure of the microspheres changes. It has an unpredictable impact on its degradation rate; 3) The preparation process is complex and difficult to industrialize

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