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Production method of acute exacerbation chronic heart failure animal model

An animal model, a technology for chronic heart failure, applied in the field of medicine, can solve the problems of extensive toxicity of doxorubicin, damage to the nutritional metabolism system, etc.

Inactive Publication Date: 2019-12-27
王维亭 +7
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that doxorubicin has a wide range of toxicity, not only cardiotoxicity, but also bone marrow suppression, liver toxicity, gastrointestinal tract, skin and other nutritional and metabolic system damage, which are somewhat different from the basic lesion characteristics of many clinical patients

Method used

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  • Production method of acute exacerbation chronic heart failure animal model
  • Production method of acute exacerbation chronic heart failure animal model
  • Production method of acute exacerbation chronic heart failure animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of animal model of acute exacerbation of chronic heart failure

[0027] 1 material

[0028] 1.1 Experimental animals

[0029]SD rats, SPF grade, male, 287.9±13.1 (270-310) g, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., animal production license number SCXK (Beijing) 2016-0011.

[0030] 1.2 Instruments

[0031] Vevo 770 TM -120 Doppler Ultrasonic Apparatus, product of Visual Sonics Company. SPR-320NR (2F) Millar pressure catheter, American Millar products. MP150 multi-conductor physiological signal acquisition system, product of Biopac system Inc, USA. Pump11 Pico Plus Elite infusion pump, Harvard Apparatus product.

[0032] 2 methods

[0033] 2.1 Model preparation

[0034] Rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium 60 mg / kg, and the anterolateral operative field area of ​​the chest was depilated with depilatory cream, and the fractional shortening (FS) of the left ventricle was measu...

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Abstract

The invention belongs to the field of medicines, and particularly relates to a production method of an acute exacerbation chronic heart failure animal model. The acute exacerbation chronic heart failure model is built according to double factors of a clinical cause and a clinical inducement, on one hand, the acute exacerbation chronic heart failure model has the cause of a pathological disease basis myocardial infarction of chronic heart failure, and on the other hand, the acute exacerbation chronic heart failure model has the inducement of a body fluid load on the basis of the cause. The model shows two major characteristics of heart failure exacerbation after being produced successfully, wherein the two major characteristics refer to further reduction of a systolic function on the basisthat the systolic function is already weakened, and respiration function index change similar to clinical symptoms. The model can be used for studies of effectiveness of a novel medicine, the action mechanism of the novel medicine and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a method for preparing an animal model of acute exacerbation of chronic heart failure. Background technique [0002] Acute heart failure (acute heart failure, AHF) refers to the symptoms and signs that occur rapidly or worsen secondary to abnormal cardiac function. AHF includes new-onset AHF and acute decompensated or acute exacerbation of chronic heart failure (ADHF or AEHF) Two types, of which AEHF is more common, accounting for about 70% to 80% of AHF. The prognosis of AHF is very poor, the in-hospital mortality rate is 3%, the 6-month rehospitalization rate is about 50%, and the 5-year mortality rate is as high as 60%. AEHF itself has disease etiology and pathophysiological basis such as cardiac structure or function damage, and its causes include infection, arrhythmia, hypertension, inappropriate adjustment or discontinuation of drugs (poor treatment compliance), excessi...

Claims

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Application Information

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IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 王维亭郝春华张珊孙双勇张蕊徐向伟赵专友汤立达
Owner 王维亭
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