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Vitamin E preparation and preparation method thereof

A vitamin and microcrystalline cellulose technology, applied in the directions of antidote, pill delivery, pharmaceutical formulation, etc., can solve the problems of oily surface of the tablet, sticking and punching of the tablet, reduce oily oil, release evenly, and improve the formation of preparations. sexual effect

Active Publication Date: 2020-02-25
JIANKANGYUAN PHARMA GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Even so, when the inventor used the vitamin E co-crystal as a raw material to trial-produce vitamin E tablets, he still encountered problems such as sticking and punching of the tablet, and oily surface of the tablet.

Method used

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  • Vitamin E preparation and preparation method thereof
  • Vitamin E preparation and preparation method thereof
  • Vitamin E preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～10

[0067] Examples 1-10 Composition of vitamin E and tablet containing said composition

[0068] The composition of vitamin E described in Examples 1-10 and the composition of the tablet are shown in Table 1 and Table 2; the corresponding tablets of each embodiment are prepared according to the following method:

[0069] (1) Take each material by weighing as shown in Table 1 and Table 2, and set aside;

[0070] (2) Mix vitamin E eutectic with emulsifier and adsorbent for T1 minute to obtain material A, which is set aside; T1 is shown in Table 3;

[0071] (3) Add diluent and disintegrant to material A and mix for T2 minutes to obtain material B, which is set aside; T2 is shown in Table 3;

[0072] (4) Add lubricant to material B and mix for T3 minutes to obtain material C for subsequent use; T3 is shown in Table 3;

[0073] (5) Compress material C into tablets, coated or uncoated.

[0074] Coating process parameters are: coating liquid solid content: 10%; coating solvent: puri...

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Abstract

The invention discloses a vitamin E preparation and a preparation method thereof, and provides a vitamin E composition which comprises, by weight, 1 part of vitamin E co-crystals, 0.5-1.25 parts of diluents, 0.15-0.4 part of adsorbing agents, 0.03-0.09 part of emulsifying agents, 0.05-0.15 part of disintegrating agents and 0.01-0.05 part of lubricating agents. The invention further provides a vitamin E tablet with the composition and a preparation method of the vitamin E tablet. The composition effectively solves the problems of extensive diffusion of oil, sticking and the like in the pressingprocess of tablets when tablets are prepared from the vitamin E co-crystals.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a vitamin E preparation and a preparation method thereof. Background technique [0002] Vitamin E (Vitamin E) is a fat-soluble vitamin, soluble in organic solvents such as fat and ethanol, but insoluble in water. Vitamin E is an important antioxidant and free radical scavenger, and can also interrupt lipid peroxidation. Therefore, vitamin E has many clinical applications. [0003] Due to the physical and chemical properties of vitamin E itself, the common preparations on the market are soft capsules. However, problems such as capsule shell leakage and adhesion, material migration, slow disintegration, and unqualified dissolution occur during storage of soft capsules. Moreover, gelatin or its modified products are generally used as the main component glue of the soft capsule material, but for vegetarians, gelatin or its modified products derived from anima...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/355A61K47/38A61K47/26A61K47/02A61K47/04A61P39/06
CPCA61K31/355A61K9/2054A61K9/2018A61K9/2009A61P39/06
Inventor 陆文歧史冠华何水杰常弘杰毛晓茉伍彪
Owner JIANKANGYUAN PHARMA GROUP
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