Experimental method for searching key sites for inducing gait movement through intraspinal micro-stimulation
An experimental method and site technology, applied in the field of CPG site research, can solve problems such as the inability to regulate and control CPG to regulate lower limb movement, and achieve the effect of improving hands-on ability
Pending Publication Date: 2020-04-10
NANTONG UNIVERSITY
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[0004] Although it is pointed out in the literature that surface skin stimulation, muscle stimulation, dorsal root nerve stimulation, and rat tail rubbing may induce rhythmic gait movements in rats' lower limbs, these are not the key sites for inducing CPG activity, because stimulation These sites cannot play a role in regulating and controlling CPG and regulating lower limb movement
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[0027] The biological nerve electrode filaments were implanted into multiple muscles of adult mice, and the extraspinal electrical stimulation was performed on SD rats. By analyzing the electromyographic signals, the behaviors of the hind limbs of SD rats were analyzed.
[0028] However, the experiment of this subject proves that by applying epidural electrical stimulation to the T12 segment of the spine (corresponding to the L2 segment of the spinal cord) of SD rats, rhythmic and alternating hindlimb movements can be effectively induced. Changing the polarity of the stimulus signal reverses the alternation pattern. In this experiment, the Master-9 stimulation signal generator was used to generate a single pulse stimulation signal, the pulse period was 30ms, the pulse width was 200μs, and the stimulation amplitude was between 220-500μA. After multiple electrical stimulation experiments, stimulating the spinal segment T12 (corresponding to the spinal cord L2 segment) can cause ...
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Abstract
The invention relates to an experimental method for searching key sites for inducing gait movement through intraspinal micro-stimulation. The method comprises the following steps: taking a rat which is dead within ten minutes, transecting the injured spinal cord, carrying out three-dimensional scanning-type electrical stimulation on a waist expansion area, and searching a site P where left and right telescopic legs alternately move; reserving the site P when the polarity of the stimulation signal is changed and the left leg and right leg alternating mode is induced to invert; continuously searching sites meeting the requirement and having the minimum stimulation signal threshold value near the site P, and determining the sites as key sites for inducing gait movement; normalizing the coordinates of the key sites; and repeating the steps for a plurality of rats, and counting the coordinate range of the normalized gait movement key sites. The invention provides a test method for researching the key sites of the rat electric excitation gait movement, the key sites for inducing the gait movement can be accurately found by the method, and the verification can be carried out through tests, so that the method has very important significance for scientific research and teaching in the field.
Description
technical field [0001] The invention relates to the technical field of CPG site research, in particular to an experimental method for searching key sites for inducing gait movement by micro-stimulation in the spinal cord. Background technique [0002] CPG (Central pattern generator) is a part of the central nervous system, a functional network composed of interneurons. The network makes motor neurons emit rhythmic nerve signals and generate certain movement patterns. Here, "rhythm" movement refers to stretching and alternating movements in a broad sense. [0003] With the continuous development of electronic technology, the application of Functional Electrical Stimulation (FES) technology as a potential functional reconstruction method for patients with spinal cord injury has attracted extensive attention. Functional electrical stimulation stimulates muscles or nerves with a certain sequence of pulse currents, thereby restoring lost or damaged motor functions, and provides ...
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Login to View More IPC IPC(8): A61N1/36A61B5/0488
CPCA61N1/36003A61N1/36062A61B2503/42A61B2503/40A61B5/389
Inventor沈晓燕李智玲马磊
OwnerNANTONG UNIVERSITY