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A platelet drug-carrying system targeting tumors and improving radiotherapy sensitivity and preparation method thereof

A platelet and sensitivity technology, applied in the direction of antineoplastic drugs, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of affecting radiotherapy sensitivity and varying therapeutic effects, and achieve inhibition of oxidative phosphorylation of tumor cells , improve sensitivity, improve tumor targeting effect

Active Publication Date: 2022-05-03
SHEYANG RES INST OF NANJING UNIV
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Problems solved by technology

[0003] Radiotherapy is suitable for almost all tumors, but the therapeutic effects are not the same, and the oxygen content of tumor cells directly affects the sensitivity of radiotherapy

Method used

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  • A platelet drug-carrying system targeting tumors and improving radiotherapy sensitivity and preparation method thereof
  • A platelet drug-carrying system targeting tumors and improving radiotherapy sensitivity and preparation method thereof
  • A platelet drug-carrying system targeting tumors and improving radiotherapy sensitivity and preparation method thereof

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Embodiment Construction

[0030] The present invention will be described in detail below in conjunction with specific embodiments.

[0031] The specific preparation process of the platelet drug-loaded system targeting tumors and improving radiotherapy sensitivity of the present invention is as follows:

[0032] 1. Preparation of Platelets

[0033] (1) SPF grade SD rats were anesthetized by intraperitoneal injection of 0.3 mL / kg body weight with 10% chloral hydrate solution, three-line positioning was used to determine the puncture site, blood was collected with a blood collection needle, and blood was collected with negative pressure in a blood collection tube.

[0034] (2) To separate platelets, blood and plasma samples were centrifuged at 100 g for 20 minutes at room temperature to separate red blood cells and white blood cells.

[0035] (3) The obtained platelets were centrifuged at 100 g for 20 minutes to remove remaining blood cells. PBS buffer containing 1 mM EDTA and 2 mM prostaglandin E1 (PGE...

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Abstract

A platelet drug-loading system that targets tumors and improves radiotherapy sensitivity. The platelet drug-loading system refers to a rat platelet drug-loading system, which is a mixture of mPEG-PCL-modified atovaquone, PEG-modified nano-gold and rat platelets, namely Ato ‑Au@Plt; said targeting tumor, improving radiotherapy sensitivity The platelet drug-loading system uses platelets as a carrier to achieve long circulation in vivo and targeted release of drugs in the tumor microenvironment, and improve the radiotherapy sensitivity of tumors. The invention activates the platelet carrier through the tumor microenvironment, deforms, aggregates, and targets the tumor to release the drug; the released drug can inhibit the oxidative phosphorylation of tumor cells, solve hypoxia, and at the same time synergize with the nano-gold to improve the sensitivity of the tumor to radiotherapy , and then improve the effect of radiotherapy.

Description

technical field [0001] The present invention specifically relates to a drug-carrying system that targets tumors, improves radiotherapy sensitivity, and then improves radiotherapy treatment effect. Background technique [0002] Although a variety of anti-tumor drugs have been marketed at present, the anti-tumor effect is not satisfactory due to poor tumor targeting and poor accumulation ability in tumors. How to efficiently deliver anti-tumor drugs into tumors, increase the concentration of drugs in tumor sites, and reduce their concentrations in normal tissues has become a hot spot in the field of pharmaceutical research. [0003] Radiotherapy is suitable for almost all tumors, but the therapeutic effects are not the same, and the oxygen content of tumor cells directly affects the sensitivity of radiotherapy. Radiosensitization is an effective way to improve the effect of radiotherapy and reduce side effects. Radiotherapy sensitizers and solutions to tumor hypoxia can play...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/60A61K9/50A61K47/46A61K31/122A61P35/00
CPCA61K9/5068A61K41/0038A61K31/122A61K47/60A61P35/00A61K2300/00
Inventor 胡勇夏栋林罗星谕蒋炜张超
Owner SHEYANG RES INST OF NANJING UNIV
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