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55 results about "High-LET Radiotherapy" patented technology

An amount of radiation that is greater than that given in typical radiation therapy. High-dose radiation is precisely directed at the tumor to avoid damaging healthy tissue, and may kill more cancer cells in fewer treatments.

Patient body position intelligent monitoring system based on deep learning

The invention relates to the technical field of medical monitoring, in particular to a patient body position intelligent monitoring system based on deep learning, which comprises a data acquisition module, a preprocessing module, a body position recognition model construction and training module, a body position monitoring module, an early warning module and a database module. The data acquisition module acquires body position image data of a radiotherapy patient; the preprocessing module cleans and standardizes the data; the body position recognition model is trained according to the labeled data and the requirements of a doctor; the body position monitoring module inputs the preprocessed data into a model to obtain an identification result, and compares the identification result with a standard body position to monitor consistency and a treatment position; the early warning module gives out early warning when abnormity occurs; the database module stores various data. The system can improve the radiotherapy precision, guarantee the safety of patients, improve the working efficiency, optimize the radiotherapy process, provide data support for medical research and promote medical informatization, and has important clinical value and wide application prospects.
Owner:THE FIRST AFFILIATED HOSPITAL OF FUJIAN MEDICAL UNIV

Device for tracking tumor position in real time in radiotherapy

The invention discloses a device for tracking a tumor position in real time in radiotherapy, and solves the problems of delay and inaccuracy in a traditional tumor position prediction method through a multi-model fusion method combining a deep learning model and a mathematical prediction model. Different from a traditional prediction method depending on an in-vitro marker or iconography technology, the tumor position is predicted in real time by adopting a long-short-term memory network, and the change of the tumor position along with respiratory movement is accurately captured by utilizing the strong time sequence modeling capability of the long-short-term memory network. By introducing the mathematical prediction model to compensate the future position of the tumor, the method can effectively solve the prediction error caused by system delay, and ensures that rays can accurately irradiate the tumor area in dynamic tumor tracking radiotherapy, thereby improving the accuracy and treatment effect of radiotherapy.
Owner:PEACE HOSPITAL AFFILIATED TO CHANGZHI MEDICAL COLLEGE

An oval body adjustable gynecological close-range rear-loading source applicator

An oval body adjustable gynecological close-range after-loading source applicator solves the problem that cervical cancer patients who cannot adapt to various vaginal environments in the prior art are prone to errors in radiotherapy doses, leading to tumor control failure and aggravated side effects. It includes an intermediate connecting frame composed of a connecting frame body, characterized in that: the source applicator bend is inserted into the bend installation hole at the upper end of the intermediate connecting frame; the oval body left hemisphere and the oval body right hemisphere symmetrically arranged on both sides of the intermediate connecting frame are both composed of hemispherical shells, and the opposite sides of the two hemispherical shells are respectively provided with concave cavities; the oval body left hemisphere and the oval body right hemisphere are connected to the intermediate connecting frame through an oval body adjustment mechanism. It has a reasonable design and a compact structure, can meet the treatment needs of different types of patients with mid- and late-stage cervical cancer radiotherapy, is easy to operate, can effectively improve the quality of radiotherapy, is non-invasive, has small side effects after treatment, is economical and practical, and has good patient compliance.
Owner:LIAONING PROVINCIAL CANCER HOSPITAL

Radiotherapy positioning alignment control method and system based on image recognition

The invention discloses a radiotherapy positioning alignment control method and system based on image recognition, and belongs to the technical field of medical instruments, and the method comprises the steps: shooting an image containing a laser cross curve irradiated by a positioning laser lamp on the body surface of a patient and a simulation positioning cross curve in real time; calculating an actual distance between the laser cross curve and the simulated positioning cross curve in the image based on an image recognition algorithm; and adjusting the displacement and posture of the six-dimensional radiotherapy bed based on the actual distance, and when the actual distance is smaller than a preset standard value, completing radiotherapy positioning. According to the scheme, the radiotherapy positioning efficiency, the radiotherapy positioning progress and the radiotherapy positioning quality can be improved.
Owner:HENAN CANCER HOSPITAL

Portable three-dimensional dose verification device for radiotherapy

The utility model discloses a portable three-dimensional dose verification device for radiotherapy. The portable three-dimensional dose verification device comprises a water tank assembly, a first measuring probe and a probe moving assembly, the water tank assembly comprises a tank body and a tank cover, the tank body and the tank cover are connected in a sealed mode to form a sealed space for containing water, and the front side of the tank body is provided with a first incidence window for beam current to penetrate through. The probe moving assembly is arranged in the box body, the first measuring probe is arranged on the probe moving assembly, and the probe moving assembly is configured to drive the first measuring probe to linearly move in the beam incidence direction in water, so that dose distribution measurement of the first measuring probe at different positions is achieved. The portable three-dimensional dose verification device for radiotherapy provided by the utility model is compact and small in structure and high in working efficiency, meets the requirement of placing the box body at different angles by adopting a sealing structure, not only meets the traditional treatment angle requirement, but also can meet the beam detection requirement in multidirectional irradiation in Gantry treatment, saves the beam time, and improves the radiotherapy efficiency.
Owner:INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI

Automatic control device, method and system for ray emission

The invention relates to the technical field of radiotherapy, and particularly discloses an automatic control device, method and system for ray emission, a beam needle and a radiotherapy needle are in non-physical connection, and when it is monitored that the phase position between the beam needle and the radiotherapy needle meets the ray emission condition, the beam needle and the radiotherapy needle are in non-physical connection. The radiation source is controlled to emit rays to the radiotherapy part, the rays are accurately emitted to the radiotherapy part through the beam needle, the air and the radiotherapy needle, the radiation source does not need to be connected with the radiotherapy part through the radiotherapy needle, the situation that displacement of the radiation source in the radiation direction changes is reduced, the emission accuracy of the rays is improved, and the radiation effect is improved. Therefore, the accuracy, convenience and efficiency of radiotherapy are improved, and the risk of radiotherapy is reduced. The radiotherapy needle is directly guided into the radiotherapy part in a sealed manner, so that the wound of the radiotherapy part can be reduced, and the reduction of the trauma suffered by the radiotherapy object is facilitated; and the damage conditions, such as bending, fracture and fracture, of pipelines of the beam needle and the radiotherapy needle are reduced.
Owner:GUANGDONG INST OF LASER PLASMA ACCELERATOR TECH

Breast cancer radiotherapy healthy side hand fixing device

The utility model discloses a breast cancer radiotherapy healthy side hand fixing device which needs to be used in cooperation with a breast bracket and comprises a base, the base is in a U-shaped groove shape with a transverse opening, a supporting ball is arranged at one end of the upper plane of the base, the bottom of the supporting ball is a plane, and a stud A is fixed to the center of the plane. The upper plane of the base is provided with a through hole through which a stud A passes in a matching manner, and the supporting ball is locked by a nut on the stud A; two spaced threaded sleeves are fixed in the upper plane of the base, studs B are in threaded connection with the interiors of the threaded sleeves, cross-shaped rotary knobs are fixedly connected to the top ends of the studs B, and pressing plates are fixed to the bottom ends of the studs B; transparent scale observation windows are arranged between the two studs B and on the upper plane and the side plane of the base, and scale pointers are arranged in the middles of the observation windows. According to the utility model, the healthy side arm of a breast cancer radiotherapy patient can be always kept at a fixed position in each radiotherapy process, and the resetting precision and the curative effect of radiotherapy are improved.
Owner:QIQIHAR FIRST HOSPITAL

Buccal device for radiotherapy

The utility model discloses a buccal device for radiotherapy, which belongs to the technical field of medical instruments and comprises a tongue depressor, a tongue depressor and a tongue depressor holder. The buccal cylinder is arranged on the outer side of the tongue depressor in a sliding and sleeving manner; the adjusting unit is connected with the tongue depressor so as to adjust the position of the buccal tube on the tongue depressor; the connecting plate is connected with one end, far away from the buccal tube, of the tongue depressor; one end of the fixing unit is connected with the connecting plate in a relative position adjustable mode, and the other end of the fixing unit is bent to be attached to the jaw. According to the buccal device for radiotherapy, the depth of the tongue depressor extending into the oral cavity can be adjusted, the stability of the buccal device for radiotherapy is improved through the fixing plate, and the fixing position is prevented from being changed.
Owner:SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT

Radiotherapy monitoring management system and method based on cloud computing

The present invention discloses a radiotherapy monitoring management system and method based on cloud computing, and belongs to the field of medical informatics technology. The method includes: a standard data acquisition module, which is used to acquire data processing standard data and radiotherapy standard data; an actual data acquisition module, which is used to acquire data processing actual data and radiotherapy actual data; a data processing capability index acquisition module, which is used to acquire data processing capability index; a radiotherapy accuracy index acquisition module, which is used to acquire radiotherapy accuracy index; a radiotherapy monitoring management system performance index acquisition module, which is used to acquire radiotherapy monitoring management system performance index; and an analysis module, which is used to analyze the performance of the radiotherapy monitoring management system based on cloud computing according to the radiotherapy monitoring management system performance index. The present invention achieves the effect of improving data processing capability and improving radiotherapy accuracy by evaluating and improving the radiotherapy monitoring management system, and solves the problem of low radiotherapy accuracy caused by limited data processing capability in the prior art.
Owner:THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV

Fixing device suitable for lower limb tumor radiotherapy

The utility model aims to provide a fixing device suitable for lower limb tumor radiotherapy, which relates to the technical field of medical instruments, and is suitable for patients with different leg lengths by controlling the distance between an adjusting bracket on an adjusting plate and the tail end of a bed body through the telescopic installation of the adjusting plate at the tail end of the bed body. The height and the position of the bracket can be controlled and adjusted through stretching and transverse sliding of the telescopic rod, and the legs and the feet of a patient are flexibly supported and fixed according to the radiotherapy body position requirement; the legs of a patient are clamped and fixed through the fixing plate slidably arranged on the adjusting base, the adjusting base slides through an arc line, the legs and the feet of the patient are made to deflect, slight extroversion or introversion is achieved, the inner sides or the outer sides of the legs of the patient are exposed, the radiotherapy effect is improved, and scales are arranged on the telescopic rod in the telescopic direction of the telescopic rod, so that the radiotherapy effect is improved. Scales are arranged at one end of the adjusting base in the sliding direction of the adjusting base, and scales are arranged on the edge of the arc-shaped groove, so that the repeatability of the radiotherapy body position is enhanced.
Owner:YUNNAN CANCER HOSPITAL (THE THIRD AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV)

Radiotherapy system and control method therefor, computing device and computer readable storage medium

PendingCN122351735ANuclear medicineInvoluntary movements
This disclosure relates to a radiotherapy system, a method for controlling the radiotherapy system, a computing device, and a computer-readable storage medium. In one aspect, the radiotherapy system includes: a radiotherapy apparatus including a source device for emitting therapeutic rays; a guide rail extending through the radiotherapy apparatus; and a shielding door movably disposed on the guide rail for movement between a first position and a second position, wherein, in the first position, the shielding door is located below the source device to shield the therapeutic rays; and in the second position, the shielding door is moved away from below the source device to allow the therapeutic rays to irradiate a radiotherapy space below the source device. This effectively alleviates the target subject's tension, depression, and other emotional states, thereby effectively reducing involuntary movements of the target subject and improving radiotherapy accuracy.

Six-degree-of-freedom proton heavy ion radiotherapy bed

A six-degree-of-freedom proton heavy ion radiotherapy bed comprises a bed plate and a base, a Z-axis rotating module is arranged on the base, an XY-axis overturning module is arranged on the Z-axis rotating module, an XY plane moving module is arranged on the XY-axis overturning module, and the bed plate is arranged on the XY plane moving module; in conclusion, the flexibility and precision of the radiotherapy bed can be remarkably improved, and the system can more accurately position the patient to the optimal treatment position by combining the multi-dimensional adjustment capabilities of rotation, overturning, translation and the like, so that the radiotherapy effect is improved.
Owner:WUXI UNIV

Head and neck cancer radiotherapy dose prediction method based on cross perception fusion

The invention discloses a head and neck cancer radiotherapy dose prediction method based on cross perception fusion. The method comprises the following steps: (1) establishing a training data set containing a patient CT image, a planned target region, an organ at risk and real dose distribution; (2) constructing a generative adversarial network based on cross-aware fusion, introducing a cross-aware fusion module into a generator to realize deep interaction and fusion of local and global features, and introducing a multi-scale cross-window self-attention coding network to constrain the difference between generation and real dose on multiple scales; (3) constructing a hybrid loss function based on the discriminator and the multi-scale cross window self-attention coding network; (4) training the generative adversarial network by using the training data set; and (5) testing data to be tested by using the trained network, wherein the output of the generator is a dose prediction result. According to the invention, direct generation of head and neck cancer radiotherapy dose distribution can be realized, doctors can be assisted in making an accurate radiotherapy plan, and the radiotherapy curative effect is improved.
Owner:HUNAN UNIV OF SCI & TECH

Radiotherapy body position fixing plate and forming method thereof

The invention discloses a radiotherapy body position fixing plate and a forming method thereof. The method comprises the steps that a body frame plate used for being fixedly arranged on a radiotherapy treatment bed is formed; three spaced positioning parameter selection areas are formed on one side of the body frame plate, and each positioning parameter selection area comprises at least four hollow sub-areas; a positioning parameter display device used for displaying positioning parameters of the body frame plate under the image is formed in each sub-region, and the positioning parameter display device comprises a positioning parameter card capable of displaying positioning parameter information of the body frame plate under the image. According to the radiotherapy body position fixing plate, positioning parameters used when a patient is positioned can be displayed on an image, a treatment plan is prevented from being made again, the treatment positioning error rate is reduced, a therapist can manually modify the specific parameter value of the positioning parameters during positioning, the value can be displayed on a positioning image, and the positioning accuracy is improved. The real positioning parameters of the body position fixing plate used by the current patient can be truly reflected, and the radiotherapy effect is improved.
Owner:PEKING UNIVERSITY FIRST HOSPITAL (PEKING UNIVERSITY FIRST CLINICAL MEDICAL COLLEGE)

A radiotherapy method based on image processing

This invention provides an image processing-based radiotherapy method, belonging to the field of medical image processing and radiotherapy technology. This method acquires multi-dimensional data such as the patient's CT images, physiological state information, body mass index, and gender. After preprocessing the CT images, it utilizes a deep convolutional neural network and multimodal feature fusion technology to extract and fuse image features, physiological state features, weight features, and gender features to generate high-quality feature vectors. Furthermore, through semi-supervised learning, combined with labeled and unlabeled CT images, it adaptively adjusts the radiotherapy dosage, thereby achieving precise radiotherapy. This invention, employing the above-mentioned image processing-based radiotherapy method, can effectively improve the personalization and accuracy of radiotherapy planning, and has significant technical application value.
Owner:ANKANG HIGH TECH HOSPITAL

Gold nano radiotherapy sensitizer for surface-enhanced Raman spectroscopy and preparation method and application of gold nano radiotherapy sensitizer

The invention relates to a gold nano radiotherapy sensitizer for surface enhanced Raman spectroscopy and a preparation method and application thereof. Specifically, the invention provides a composite material with manganese dioxide wrapped by gold nanoparticles, which has improved surface enhanced Raman spectrum signals, improved X-ray deposition efficiency and improved tumor killing effect in radiotherapy. And a nucleic acid aptamer for targeting tumors can be carried, so that the targeting property and the safety are improved, and wide application prospects are realized in the fields of radiotherapy sensitization, tumor diagnosis and the like. In addition, the invention further provides a method for preparing the gold nano composite material, dopamine-grafted polyethylene glycol, gold nano particles, potassium permanganate and the like in different proportions are used as raw materials, and the gold nano composite materials with different shapes and sizes can be prepared and used for different purposes. The preparation method is simple, easy to operate and beneficial to industrial production and application.
Owner:SICHUAN UNIV

System and method for estimating and predicting tumor motion of radiotherapy robot

The invention discloses a tumor motion estimation and prediction system and method for a radiotherapy robot, and relates to the technical field of radiotherapy robots. The radiotherapy robot tumor motion estimation and prediction system comprises a state relation curve analysis unit, a tumor motion tracking acquisition unit, a model robot integration unit, a radiotherapy parameter modification and adjustment unit and a real-time prediction use unit. The method comprises the following steps: firstly, acquiring tumor positions in different breathing stages through a magnetic resonance imaging technology, and analyzing a relationship between the tumor positions and a breathing state so as to accurately understand a change rule of the tumor along with breathing movement; meanwhile, soft tissue subtraction images and tumor motion trail data are obtained through the X-ray technology, understanding of tumor motion characteristics is enhanced, later radiotherapy positioning is more accurate, the radiotherapy robot can track and treat tumors more intelligently, and the radiotherapy accuracy and efficiency are improved to the maximum extent.
Owner:NANTONG TUMOR HOSPITAL

A head and neck cancer radiotherapy dose prediction method based on cross-sensing fusion

The application discloses a head and neck cancer radiotherapy dose prediction method based on cross perception fusion, comprising the following steps: (1) establishing a training data set containing a patient CT image, a planning target volume, an organ at risk and a real dose distribution; (2) constructing a generative adversarial network based on cross perception fusion, introducing a cross perception fusion module in the generator, realizing the deep interaction and fusion of local and global features, and introducing a multi-scale cross window self-attention coding network to constrain the difference between the generated and real doses at multiple scales; (3) constructing a hybrid loss function based on the discriminator and the multi-scale cross window self-attention coding network; (4) training the generative adversarial network by using the training data set; and (5) testing the data to be tested by using the trained network, and the output of the generator is the dose prediction result. The application can realize the direct generation of the head and neck cancer radiotherapy dose distribution, assist doctors in formulating accurate radiotherapy plans, and improve the radiotherapy effect.
Owner:HUNAN UNIV OF SCI & TECH

Infrared marker-based method for calculating degree of deformation of thermoplastic film and identifying patient

PCT designated stage expiredWO2025108442A1Using optical meansNuclear medicineTherapy planning
Disclosed in the present invention is an infrared marker-based method for calculating the degree of deformation of a thermoplastic film and identifying a patient. In the method, during a treatment plan formulation phase, infrared markers are fixed to a thermoplastic film of a patient, position data of the thermoplastic film and the infrared markers are acquired by means of an image acquisition device such as CT and magnetic resonance, and on the basis of the relative position relationship between the infrared markers, basic information and treatment information of the patient are bound. During treatment, the positions of the infrared markers are acquired in real time to calculate the degree of deformation of the thermoplastic film. Additionally, by identifying the relative position relationship between the infrared markers, the basic information and treatment information of the patient are identified. The method can effectively monitor the deformation of a thermoplastic film during radiotherapy, thereby improving the precision and quality of radiotherapy.
Owner:NANJING CHENGDA MEDICAL TECH

Radiotherapy tumor movement following system and method

The invention relates to the technical field of adjuvant therapy, and provides a radiotherapy tumor motion following system and method, which respectively controls the translational motion of a treatment bed and adjusts the motion parameters of an MLC blade based on a displacement vector from the acquisition of a respiratory motion signal and the inversion of the elastic modulus distribution of a target tissue to accurate displacement analysis. According to the following system, tumor motion compensation is obtained, all links are linked with one another, precise tracking and dynamic compensation of tumor motion are achieved, and compared with a traditional radiotherapy technology, the following system can remarkably improve radiotherapy precision, reduce radiotherapy errors caused by tumor motion and reduce the radiation dosage to surrounding normal tissues, and the radiotherapy precision is improved. And the problem caused by tumor movement in radiotherapy is solved from multiple dimensions.
Owner:NANJING WANFENG BIOMEDICAL CO LTD

Method for classifying and evaluating breathing modes of chest and abdomen tumor patients before radiotherapy

The invention relates to a breath pattern classification and evaluation method for chest and abdomen tumor patients before radiotherapy. The method comprises the steps that respiratory movement signals of the chest and the abdomen of a patient are collected, and original signal data reflecting changes of chest and abdomen respiratory movement along with time are obtained; preprocessing and feature extraction are conducted on the original signal data, a plurality of breathing feature parameters are obtained, and the feature parameters comprise a chest breathing movement amplitude parameter, an abdomen breathing movement amplitude parameter, breathing frequency, a chest and abdomen breathing synchronism index and a chest and abdomen breathing movement phase difference; inputting the characteristic parameters into a breathing mode classification model based on machine learning, and identifying and classifying the breathing mode of the patient to determine that the breathing mode of the patient belongs to an abdominal breathing mode, a thoracic breathing mode, a mixed breathing mode or other abnormal breathing modes; and evaluating the breathing mode of the patient based on the classification result and the characteristic parameters. According to the invention, the safety and effectiveness of the radiotherapy process are improved.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Vagina length scale for radiotherapy

The utility model relates to the technical field of medical auxiliary instruments, in particular to a vagina length scale for radiotherapy, which is characterized in that a supporting structure extends into the vagina of a patient to open the vagina of the patient, a measuring structure is guided through a limiting structure, and then a doctor extends the measuring structure into the vagina of the patient to measure the length of the vagina of the patient. The vagina length of a patient is measured, so that the practicability of the vagina length scale for radiotherapy is improved; comprising a supporting structure; the device further comprises a limiting structure and a measuring structure. The supporting structure and the measuring structure are both installed on the limiting structure. The supporting structure is used for supporting the vagina of a patient, the limiting structure is used for limiting and guiding the measuring structure, and the measuring structure is used for measuring the length of the vagina of the patient.
Owner:BEILUN DISTRICT PEOPLES HOSPITAL OF NINGBO CITY

Application of SNORA58 as target spot in preparation of medicine for improving esophageal cancer radiotherapy sensitivity

The invention provides application of SNORA58 serving as a target spot in preparation of a medicine for improving esophageal cancer radiotherapy sensitivity. The SNORA58 is used as a target to be applied to preparation of the medicine for improving the radiotherapy sensitivity of the esophageal cancer, and the sensitivity of a patient with the esophageal cancer to radiotherapy can be improved by inhibiting the SNORA58 or activating a downstream signal channel JNK signal channel regulated by the SNORA58, so that the radiotherapy curative effect of the patient with the esophageal cancer is promoted. Moreover, the invention discloses a marker SNORA58 for esophageal cancer radiotherapy resistance and a sensitizing radiotherapy target JNK signal channel, and clarifies a new mechanism of esophageal cancer radiotherapy resistance, namely the action and mechanism of SNORNA58 in cell ferroptosis caused by radiotherapy. The method has extremely important clinical significance for deeply analyzing a molecular mechanism of esophageal cancer radiotherapy resistance, explaining radiotherapy differences of esophageal cancer patients and formulating an individualized treatment scheme to improve the radiotherapy curative effect and prognosis of the patients.
Owner:SUN YAT SEN UNIVERSITY CANCER CENTER (CANCER HOSPITAL AFFILIATED TO SUN YAT SEN UNIVERSITY CANCER RESEARCH INSTITUTE OF SUN YAT SEN UNIVERSITY)

A liver tumor radiotherapy dose prediction method based on a diffusion model

The application discloses a liver tumor radiotherapy dose prediction method based on a diffusion model, and an embodiment thereof is: 1) data collection; 2) preprocessing; 3) constructing a dose prediction model; 4) constructing a loss function; 5) training the prediction model; and 6) dose prediction. The application introduces a beam field, thereby providing the dose prediction model with radiotherapy beam direction information and dose deposition information in a beam propagation process; in order to efficiently utilize input condition information, in a noise prediction network, a multi-branch encoder and a multi-condition aggregation module are designed to realize feature extraction and aggregation of different input condition information, and an asymmetric fusion module is designed to reduce information loss in the input condition information processing process. Compared with a traditional deep learning method, the application can generate more realistic dose prediction results, is helpful to improve the efficiency of radiotherapy plan design, and formulates a personalized treatment plan, and has great practical application value.
Owner:CENT SOUTH UNIV

Application of MNX1-AS1 inhibitor in preparation of product for enhancing breast cancer radiotherapy sensitivity and preparation method of sensitizer

The invention relates to the technical field of tumor molecular biology, and provides application of an MNX1-AS1 inhibitor in preparation of a product for enhancing breast cancer radiotherapy sensitivity and a preparation method of a sensitizer. The invention also provides application of the long-chain non-coding RNAMNX1-AS1 detection reagent in preparation of products for predicting and diagnosing breast cancer cell radiotherapy resistance and / or prognosing breast cancer cell radiotherapy curative effect. The method has the advantages that (1) the long-chain non-coding RNA MNX1-AS1 detection is beneficial for timely judging whether breast cancer cells of a patient have the tendency of radiotherapy resistance or easy-to-acquire radiotherapy resistance or not, and a reference basis for the effective degree of radiotherapy is provided, so that a proper treatment strategy is timely adjusted and given, and the lifetime of the patient is prolonged; (2) the novel breast cancer radiotherapy nano sensitizer provided by the invention can be used for inhibiting two main signal transduction molecules causing radiotherapy resistance and tumor metastasis while breaking the abnormal oxidation-reduction state of cells in a three-in-one manner, and is beneficial to enhancing the radiotherapy sensitivity of breast cancer cells and improving the radiotherapy curative effect.
Owner:SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV

Head, neck and arm fixing device for chest tumor radiotherapy

The invention discloses a head, neck and arm fixing device for chest tumor radiotherapy, and relates to the technical field of medical instruments, and the main points of the technical scheme are that the head, neck and arm fixing device comprises a first base, the top of the first base is provided with a head fixing mechanism, the front is provided with a neck fixing mechanism, and two rear sides are symmetrically provided with arm fixing mechanisms. The head fixing mechanism and the arm fixing mechanism each comprise an inflation channel, an air bag and an electric telescopic rod and are matched with an inflation pump to achieve flexible clamping and mechanical positioning. The neck fixing mechanism drives an extrusion plate to be matched with the neck for fixing through a motor. The arm fixing mechanism can be adjusted front and back along the sliding rod, and all the mechanisms cooperate to achieve linkage and synchronous fixing. The device is provided with an air pressure sensor, a pressure sensor and a display screen, clamping force is accurately controlled through an integrated circuit board, and the device adapts to patients of different body types. The device can effectively limit the movement of limbs, improve the stability and repeatability of the body position, reduce the radiotherapy positioning deviation, enhance the comfort of a patient, simplify the positioning operation and improve the radiotherapy efficiency.
Owner:AFFILIATED HOSPITAL OF NANTONG UNIV

A drug combination for improving the sensitivity of FLASH radiotherapy in treating peritoneal metastasis of colorectal cancer, a method and application thereof

This invention relates to the field of biomedical technology, disclosing a drug combination and its application for improving the sensitivity of FLASH radiotherapy in the treatment of colorectal cancer peritoneal metastases. The combination comprises a therapeutically effective amount of an APOE inhibitor and / or an IL1B agonist. By combining an APOE inhibitor and / or an IL1B agonist, this invention can precisely target and intervene in abnormal gene expression after FLASH radiotherapy, thereby improving the abnormal gene expression state after FLASH radiotherapy, eliminating the negative impact of abnormal gene expression on the efficacy of radiotherapy, significantly improving the therapeutic sensitivity of FLASH radiotherapy to colorectal cancer peritoneal metastases, achieving radiosensitization, and providing a new targeted strategy for the radiotherapy treatment of colorectal cancer peritoneal metastases.
Owner:SOUTHWEAT UNIV OF SCI & TECH +1

Dose generation method and system applied to shallow X-ray radiotherapy

The invention discloses a dose generation method and system applied to shallow X-ray radiotherapy, and the method comprises the steps: generating a two-dimensional source skin distance matrix through an optical device or customized parameter configuration; converting the two-dimensional source skin distance matrix into an equivalent digital motif; synchronously constructing an X-ray source model, simulating a photon emission process and acquiring phase space data; enabling Z axes of the ray source coordinate system and the digital model body coordinate system to be collinear and the original points to coincide through coordinate system alignment operation, and establishing a dosimetry simulation model; carrying out analogue simulation by utilizing the dosimetry simulation model; and counting accumulated deposition energy in the voxels, and outputting a three-dimensional dose matrix. The system comprises a matrix construction unit, a motif construction unit, a source model construction unit, a coordinate system alignment unit, a simulation unit and a dose generation unit. According to the invention, the rationality of simulation calculation of the radiotherapy dose can be improved. The method can be widely applied to the field of dose calculation.
Owner:南方医科大学第五附属医院

Automatic control device, method and system for ray emission

The present invention relates to the field of radiotherapy technology, and specifically discloses an automatic control device, method and system for ray emission. By non-physically connecting a beam needle and a radiotherapy needle, and when monitoring that the phase position between the beam needle and the radiotherapy needle meets the ray emission conditions, the ray source is controlled to emit rays to the radiotherapy site and pass through the beam needle, through the air, and then through the radiotherapy needle to accurately emit the rays to the radiotherapy site. There is no need for the ray source to be connected to the radiotherapy site through the radiotherapy needle, which reduces the displacement of the ray source in the ray direction, thereby improving the ray emission accuracy, and further improving the accuracy, convenience and efficiency of radiotherapy, and reducing the risk of radiotherapy; and by directly and sealedly introducing the radiotherapy needle into the radiotherapy site, the wound at the radiotherapy site can be reduced, which is beneficial to reducing the trauma suffered by the radiotherapy subject; and damage to the pipelines of the beam needle and radiotherapy needle, such as bending, cracking and breaking, is reduced.
Owner:GUANGDONG INST OF LASER PLASMA ACCELERATOR TECH