49 results about "High-LET Radiotherapy" patented technology

The invention discloses a ward bed system, a radiation therapy system, a device and a storage medium. The ward bed system includes: a bed board for carrying a target object, which is provided with a slide rail, a fixed lock slot and a drag lock; bed frames for supporting the bed board and adjusting a spatial position of the bed board, which is provided with the sliding slot and a fixed locking buckle, wherein the sliding slot and the sliding rail are matched to form a sliding device, and the fixed locking buckle and the fixed locking slot are matched to form a locking device; a movable bracketused for moving the bed board between the plurality of bed frames, which is provided with the sliding slot, the fixed locking buckle and a bed board towing hook, wherein the sliding slot and the sliding rail are matched to form the sliding device, the fixed locking buckle and the fixed lock slot are matched to form a locking device, and the bed board towing hook and the drag lock are matched to form a bed board drag acting point. The embodiment of the invention solves the problem that the existing radiotherapy process leads to low efficiency of the radiotherapy device when the number of patients in the radiotherapy is large, the optimization of the radiotherapy process is realized, and the utilization rate of the radiotherapy device is increased.

The invention discloses an oral fixator, which relates to the field of medical instruments. The oral fixator comprises a fixator body; the inner part of the fixator body has a hollow structure, and the fixator body is filled with an anti-radiation material; one side of the fixator body is provided with a hard palate surface contacted with the oral hard palate, and the other side is provided with a dorsal surface of a tongue contacted with the tongue; the edge of the dorsal surface of the tongue is provided with a tongue pressing tail for pushing a tongue root part forwardly and to a mandible direction; and the tongue pressing tail is located on the oral fixator corresponding to one end of the tongue root part. The oral fixator body is set to have the hollow structure, the oral fixator body is internally filled with the anti-radiation material, rays can be effectively blocked, normal tissues can be prevented from irradiation, discomforts such as oral mucosa injuries, taste injuries and difficult mouth opening can be prevented from happening to the patient, and the radiotherapy accuracy and the effects can be improved.

The invention relates to an imitative positioning method for a radiation treatment radiation field. The method comprises the following steps of: (1) forming a patient imitation positioning treatment body position on a positioning bed in an imitation positioning machine; (2) acquiring a radiation treatment radiation field image; (3) drawing a radiation treatment target region shape by using the radiation treatment radiation field image acquired with an imitation positioning machine image work station; (4) proportionally zooming the radiation treatment target region shape; (5) making the zoomed radiation treatment target region shape appear in the display visual field of a video camera, and displaying in real time by using an indoor display of the imitation positioning machine; and (6) drawing a radiation treatment target region shape at a human body radiation treatment position with a drawing pen while observing the radiation treatment target region shape according to the radiation treatment target region shape in the visual field window of a real-time display video camera of the indoor display of the imitation positioning machine and a skin radiation treatment position to obtain a body surface drawing radiation treatment target region shape; and (7) sticking a lead wire according to the body surface drawing radiation treatment target region shape and shooting a radiation field verification image. According to the imitative positioning method, the working efficiency of radiation treatment imitation can be increased, the radiation dosage of a patient is decreased greatly, and discomfort and even hurt to a patient is not caused.

The invention discloses a radiotherapy dose evaluation system and a device and a storage medium. The radiotherapy dose evaluation system comprises a processor, and configuration and execution steps are as follows: obtaining image data of a target object, carrying out the scattering removal treatment and back projection treatment on the image data, and generating an initial flux graph under each sub-field of the current treatment; determining a weighted graph based on the initial flux graph; and inputting the weighted graph into a dose calculation system, and outputting the absorbed dose of thetarget object in the current treatment. The radiotherapy dose evaluation system provided by the embodiment of the invention can perform high-precision evaluation on the absorbed dose of the target object in each radiotherapy process, can be used for assisting dose determination of clinical radiotherapy, and improves the use accuracy of the radiotherapy dose.

The invention relates to a platelet drug delivery system for targeting tumors and improving radiotherapy sensitivity. The platelet drug delivery system is a rat platelet drug delivery system, and is amixture of mPEG-PCL modified atorvaquone, PEG modified nanogold and rat platelets, namely Ato-Au@Plt; and the tumor targeting is characterized in that the platelet drug delivery system adopts platelets as a carrier to realize in-vivo long circulation and tumor microenvironment targeted drug release, so the radiotherapy sensitivity of tumors is improved. The platelet carrier is activated through atumor microenvironment, and is deformed and aggregated to release a drug in a targeted manner; and the released drug can inhibit oxidative phosphorylation of tumor cells and solve hypoxia, and the drug and the nanogold have a synergistic effect, so that the sensitivity of tumors to radiotherapy is improved, and the radiotherapy treatment effect is further improved.

The invention provides a method and a device for predicting a dose volume histogram of an organ-at-risk of a radiotherapy plan. The method comprises the following steps: determining an anatomical structure diagram of a region-of-interest and a dose area histogram of an organ-at-risk for model training; determining a prediction model; and inputting the labeled anatomical structure diagram of the region-of-interest of a new patient into the prediction model, and predicting to obtain the organ-at-risk dose volume histogram of the new patient. According to the invention, the method and the deviceare short in prediction time consumption, high in accuracy and suitable for target regions with various prescription doses and patients with various different organ-at-risk anatomical structures, arenot limited to tumor types, can predict different tumor types, are wide in clinical application range, and can achieve automatic setting and plan quality inspection of the individualized reverse planinitial objective function, improve the radiotherapy plan design quality, shorten the design time and solve the problems of time consumption and large plan quality difference of accurate radiotherapyplan design.

The invention belongs to the technical field of radiotherapy, and particularly relates to a comfortable radiotherapy body position fixing frame which comprises a positioning frame, an omentum plate, a reset unit and a posture controller. When radiotherapy positioning is carried out each time, a human body needs to be repeatedly moved and rotated to meet the position precision required by radiotherapy, so that the time consumed by positioning is long, the time for a patient to keep a fixed posture is prolonged, and the comfort experience of the patient to be radiotherapy is reduced. Therefore, through the arrangement of a return assembly and a rotation assembly, the operation of an electric control translation stage and an electric control rotation frame is controlled in real time through the monitoring of an angular velocity sensor in the posture controller, so that the posture variation generated by a radiotherapy part and a radiotherapy equipment head is reduced as much as possible when the body posture of a radiotherapy person is adjusted after the posture of the human body is changed, the posture variation of the radiotherapy part of the human body and the radiotherapy equipment head is controlled within the range required by the radiotherapy process, and the comfort experience of the human body in the radiotherapy process is improved while the stable radiotherapy is ensured.

The invention discloses a radiotherapy plan assessment method and device based on unsupervised learning, and the method comprises the following steps: S1, obtaining a corresponding anatomical structure vector according to the data of n patients for any disease; s2, performing dimensionality reduction on the high-dimensional anatomical structure vector by using a dimensionality reduction algorithm; s3, clustering the data according to an anatomical structure by using a clustering algorithm to obtain k categories; s4, according to the k categories, analyzing and processing a clinically implemented high-quality radiotherapy plan result in the data corresponding to each category to obtain a plan scoring template corresponding to each category; s5, new data of any patient is calculated, and the category of the new data is judged; and S6, adopting the plan scoring template of the corresponding category to guide the design of the radiotherapy plan corresponding to the new data, and scoring the dose distribution result of the radiotherapy plan. According to the method, personalized evaluation of cases with different geometric structure complexity is realized, and the quality and efficiency of the radiotherapy plan are improved.

The invention discloses a medical-data-based type hierarchy extraction method. The method comprises the steps: determining to-be-processed medical data; performing data extraction processing on the to-be-processed medical data to obtain two-dimensional table data including the target medical data; and performing data analysis processing on the two-dimensional table data to obtain a data model corresponding to the target medical data. The data model reflects the type hierarchy corresponding to the target medical data, so that the data are convenient to use, and the target medical data of various types and levels in the data model can be directly used without the need of processing and analyzing the radiotherapy data in the radiotherapy equipment in a manual mode like the traditional mode. According to the invention, the radiotherapy data in the radiotherapy equipment do not need to be processed and analyzed manually; errors caused by manual processing and analysis of the radiotherapy data in the radiotherapy equipment can be avoided, so that the accuracy of determining the type hierarchy of the radiotherapy data in the radiotherapy equipment is improved, and the efficiency of processing the radiotherapy data in the radiotherapy equipment is further improved.

The invention discloses an attached headrest manufacturing method. The attached headrest manufacturing method is applied to terminal equipment. The method comprises the following steps: the terminal equipment obtains headrest attachment data during radiotherapy of the head and neck of a patient; and sending the headrest fitting data to the three-dimensional printer, so that the three-dimensional printer manufactures a fitting headrest. The invention further discloses terminal equipment and a computer readable storage medium. A radiotherapy headrest fitting the head and neck of the patient can be manufactured, the probability of position occurrence caused by headrest discomfort during radiotherapy of the patient is reduced, the irradiation dose of normal tissue of the patient is reduced, the local tumor control rate is increased, and the radiotherapy treatment effect is improved.

The invention discloses a radiotherapy body position correcting instrument, and belongs to the field of medical equipment. The radiotherapy body position correcting instrument comprises a radiotherapybed, wherein guide rods are fixedly welded to the upper ends of the two sides of the radiotherapy bed. According to the radiotherapy body position correcting instrument, a hydraulic cylinder is started to drive a movable plate to move longitudinally, the height of a bed body is convenient to adjust, and a radiotherapy person can conveniently move to the upper end face of the bed body through thedesign of the hydraulic cylinder; a second motor is started to drive a gear to rotate, and therefore a moving bed is driven to move; the position of the radiotherapy person is convenient to adjust through the design of a tooth row, and therefore accurate positioning is facilitated, and chemotherapy is facilitated; the comfort of the radiotherapy person can be improved through the design of an arc-shaped structure, and the position of the radiotherapy person can be limited; the purpose of accurate positioning can be achieved through the design of arrows and scale marks; a handle is moved upwards to drive a garbage can and a clamping block to move upwards, the clamping block is separated from constraint of a clamping groove, and the garbage can is convenient to move towards one side to be disassembled; and vomit, generated by radiotherapy reaction, of the radiotherapy person can be contained through the design of the garbage can, and environmental sanitation is improved.

The invention discloses a novel abdominal radiotherapy fixing frame special for the radiotherapy department. The novel abdominal radiotherapy fixing frame comprises a bed body, bedding and a fixing assembly. The bedding is arranged on the top surface of the bed body; the fixing assembly comprises a first side plate and a second side plate which are symmetrically and slidably connected to the top faces of the two sides of the bed body, and a top plate is slidably connected between the first side plate and the second side plate. Positioning film holes are formed in the first side plate and the second side plate respectively, and the two positioning film holes correspond to each other and are used for fixing an abdomen positioning film; pressure fixing devices are fixed to the inner ends of the two sides of the top plate and used for fixing the abdomen of a patient. A radiotherapy hole is formed in the upper end of the top plate in a hollowed-out mode, and radiotherapy rays can pass through the radiotherapy hole. The device is simple in structure, convenient to use, flexible to adjust, suitable for patients of different body types, high in applicability and capable of effectively fixing the patients, preventing the patients from actively or inactively moving in the radiotherapy process and effectively improving the radiotherapy precision.

The invention discloses the application of LINC00167 in the preparation of drugs for inhibiting tumor angiogenesis, and belongs to the technical field of biomedicine. LINC00167 is an lncRNA closely related to ionizing radiation stimulation. After X-ray irradiation, its expression level increased significantly, and with the extension of time after irradiation, the expression level became higher and higher. At the same time, the expression level of LINC00167 is positively correlated with the level of tumor angiogenesis, which means that it may play a key role in the response of tumors to radiation stimulation; this can be used to artificially inhibit the high expression of LINC00167 after irradiation, In this way, it can achieve the same effect as the commonly used clinical vascular inhibitors, improve the prognosis of tumor patients after radiotherapy, and reduce the chance of tumor recurrence.

The invention discloses application of LINC00167 in preparation of a medicine for inhibiting tumor angiogenesis, and belongs to the technical field of biological medicine. The LINC00167 is an lncRNA closely related to ionizing radiation stimulation, the expression level of the LINC00167 is remarkably increased after X-ray irradiation, and the expression level is higher and higher along with the prolonging of the time after irradiation. Meanwhile, the expression level of the LINC00167 is positively correlated with the tumor angiogenesis level, which means that the LINC00167 can play a key role in the response process of the tumor to radiation stimulation; by utilizing the point, the high expression of the LINC00167 after irradiation can be artificially inhibited, so that the same effect as that of a clinically common vascular inhibitor is achieved, the prognosis of tumor patients after radiotherapy is improved, and the recurrence probability of tumors is reduced.

The invention provides a positioning radiotherapy device based on a carrier plate and a working method, and relates to the field of medical equipment. The positioning radiotherapy device comprises a first ring and a second ring which are coaxially arranged, wherein a kinematic pair is matched between the first ring and the second ring, and the first ring and the second ring are driven to generaterelative rotation; the carrier plate is arranged on the inner ring of the first ring and used for bearing a patient; a positioning mechanism is arranged on the first ring and used for obtaining a radiotherapy target area; and a radiotherapy mechanism is arranged on the second ring, and the second ring drives the radiotherapy mechanism to rotate according to the focus position to adjust the workingposition and conduct radiotherapy on the target area. The positioning mechanism and the radiotherapy mechanism are configured respectively through the first ring and the second ring coaxially arranged, and an electronic slip ring is configured in the middle to enable the positioning mechanism to be matched with the radiotherapy mechanism, so that the purpose of positioning a target area while performing radiotherapy on the target area is achieved, operation steps in the radiotherapy process of the patient are saved, and the radiotherapy efficiency and precision are improved.

The invention relates to a method for determining a CT positioning center. The method comprises the following steps of: step 1, when CT positioning is executed, firstly performing CT scanning on a patient to obtain a current CT image of the patient; step 2, identifying and sketching a tumor target area from the CT image, and calculating an isocenter of the tumor target area; and step 3, transmitting coordinates of the isocenter to a three-dimensional laser positioning system, performing isocenter projection on the body surface of the patient by utilizing the three-dimensional laser positioning system, and setting CT marking points at a laser incident point of the body surface of the patient and / or a laser incident point of a body position fixator. According to the method, the CT positioning center can be ensured to be always positioned at a position very close to the isocenter or overlapped with the isocenter; the method is simple, and a positioning link does not need to be added in the radiotherapy process for verification, so that medical resources can be saved, the waiting period of the patient can be shortened, the radiotherapy efficiency can be improved, the number of times of radiation on the patient can be reduced, and the treatment cost of the patient can be reduced.

The invention belongs to the technical field of medical instruments, and especially relates to a tumor radiotherapy protection assembly and a tumor radiotherapy protection device. The tumor radiotherapy protection assembly comprises a worktable, a rotating shaft, a telescopic cylinder, a base, a moving rail groove, a radiotherapy end, a protection plate, a radiotherapy protection component, a moving slide arm, a pressurized air bag, an air guide pipe, an air pump, a compression spring, a pressing plate, a fixing belt and a snap ring, wherein the bottom of the worktable is provided with the rotating shaft; the lower part of the rotating shaft is connected with the base through the telescopic cylinder; and both sides of the worktable are slidably connected with the radiotherapy end through the moving rail groove. The cooperative arrangement of the pressurized air bag, an anti-radiation film, the pressing plate, the fixing belt, the snap ring and an auxiliary physiotherapy piece is beneficial to improve the radiotherapy protection effect, and the components are firmly fixed so as to enhance stability of the radiotherapy protection; under the coordination action of the moving sliding arm, the radiotherapy end, the telescopic cylinder, the moving rail groove and the rotating shaft, the protection can be adjusted flexibly to achieve the best protection effect.

The invention belongs to the technical field of radiotherapy equipment, and particularly relates to a mobile radiotherapy system. The mobile radiotherapy system comprises a mechanical arm, a radiotherapy device and a mobile base device. The movable base device comprises a lifting walking component and a supporting base frame. The radiotherapy device is arranged at the tail arm section of the mechanical arm, the lifting walking component comprises a lifting supporting platform, the supporting base frame is arranged above the lifting supporting platform, and an equipment mounting platform is formed at the top of the supporting base frame. The mechanical arm is mounted on the equipment mounting platform, the bottom of the supporting base frame horizontally extends outwards to form a plurality of mounting lugs exceeding the lifting supporting platform, and the mounting lugs are vertically connected with supporting legs. During operation, the supporting area formed by the plurality of supporting legs is larger than the area of the lifting supporting platform, so that a mass center safety area is larger, a movement range of the mechanical arm is wider, and a operation range of the radiotherapy device is widened.

The invention belongs to the technical field of radiotherapy, and specifically relates to a radiotherapy body position fixing frame, which includes a positioning frame, an omentum plate, a reset unit and a posture controller; each time a radiotherapy position is performed, the human body needs to be repeatedly moved and rotated to meet the The positional accuracy required for radiotherapy results in longer time spent on positioning, prolongs the time for the radiotherapist to maintain a fixed posture, and reduces the comfort experience of the radiotherapist; therefore, the present invention cooperates with The monitoring of the angular velocity sensor in the attitude controller can control the operation of the electronically controlled translation table and the electronically controlled slewing frame in real time, so that after the human body posture changes, the radiotherapy operator can minimize the impact on the radiotherapy site and the radiotherapy equipment head when adjusting the body position. The amount of attitude change keeps the attitude change of the radiotherapy part of the human body and the head of the radiotherapy equipment within the range required by the radiotherapy process, ensuring stable radiotherapy and improving the comfort experience of the human body during radiotherapy.

The invention provides an auxiliary device for chest and abdomen pressing during radiotherapy, belonging to the technical field of medical instruments. The auxiliary device comprises a main device body, wherein the main device body comprises two fixing plates and a pressing plate which are oppositely arranged, sliding grooves penetrate through the two ends of the pressing plate respectively, and the two fixing plates extend into the two sliding grooves respectively and are in sliding fit with the two sliding grooves. The auxiliary device also comprises a limiting assembly which can limit the pressing plate to move back and forth in the axis direction of the fixing plates. In the process of radiotherapy, the abdomen or the chest is pressed, so fluctuation generated when a patient breathes is reduced, and radiotherapy accuracy can be improved to a certain extent; and meanwhile, a tumor focus can be prevented from moving towards the head and feet, and the purpose of avoiding affecting other tissues of the body is achieved.

The invention discloses a stereotactic radiotherapy equipment isocenter calibration device, which comprises an isocenter ball mold assembly, a supporting assembly and a measuring device, and is characterized in that the isocenter ball mold assembly comprises an isocenter ball mold and a cylindrical supporting rod integrated with the isocenter ball mold; the supporting assembly is used for supporting the isocenter ball mold and the supporting rod; the measuring device rotates around the isocenter of the equipment in the first direction and swings along an arc in the second direction, the measuring device can rotate around the axis intersecting with the isocenter so as to measure the position of the isocenter of the radiotherapy equipment, and the isocenter calibration method of the stereotactic radiotherapy equipment is disclosed. The operation method is simple, the position of the isocenter can be quickly determined under the condition that the treatment head does not emit ray beams in the radiotherapy equipment installation and debugging stage, and the radiotherapy equipment installation and debugging efficiency can be improved.

The invention discloses a novel pharmaceutical application of quercetin. The new application is the application of quercetin in preparation of cancer radiotherapy sensitizing drugs. The application of quercetin in preparation of a radiotherapy sensitizer is provided for the first time, and the quercetin can effectively improve the radiotherapy sensitivity of tumor cells and improve the radiotherapy curative effect. The action mechanism of the quercetin is related to the capability of the quercetin in inhibiting androgen receptor (AR) and AR splicing variant 7 (ARv7) activating signal paths and increasing tumor cell DNA damage, and the quercetin has a wide application prospect.

The invention discloses a multifunctional translation bed for gynecological tumor radiotherapy, and belongs to the technical field of medical instruments, the multifunctional translation bed comprises a bed board main body, a front-back driving frame and a left-right driving frame are sequentially arranged below the bed board main body from top to bottom, and the front end face of the front-back driving frame is fixedly connected with two longitudinal servo motors which are uniformly distributed; the left side of the left-right driving frame is fixedly connected with a transverse servo motor, a rotary servo motor is arranged below the front-back driving frame, the lower end face of the rotary servo motor is fixedly connected with a lifting table, and the left side and the right side of the rotary servo motor are each provided with two evenly-distributed lifting air cylinders. A left-right driving block is fixedly connected to the lower end faces of the lifting table and the lifting air cylinder, a base is fixedly connected to the lower end face of a left-right driving frame, and a plurality of uniformly-distributed universal wheels are fixedly connected to the lower end face of the base, so that the multifunctional translation effect of the bed board main body is achieved, the discomfort of a patient is reduced, and the radiotherapy quality is improved.

The invention provides a new application of a biomarker VAV2 in prediction of radiotherapy sensitivity or prognosis of a patient, and provides the application of an inhibitor of the VAV2 in treatment of the patient. Preferably, the patient is diagnosed to suffer from cancer; and more preferably, the patient is diagnosed to suffer from the esophageal cancer. Preferably, the treatment includes prognosis improvement and radiotherapy sensitivity improvement.

The invention relates to the technical field of radiotherapy, and particularly relates to a CT positioning method in a radiotherapy process. The CT positioning method comprises the following steps of associating a CT positioning center with a virtual isocenter of a tumor area of a patient by using a previous CT / MR image of the patient, so that the CT positioning center is not roughly set according to experience. The CT positioning method can ensure the CT positioning center to be always at a position very close to or coincident with the isocenter with no more than 1cm of error. The method is simpler and more practical, unnecessary to add positioning for verification in the radiotherapy process, thereby saving medical resources, shortening waiting period of patients, and improving radiotherapy efficiency. The CT positioning method of the present invention also reduces radiation frequency of the patients, reduces treatment cost of the patients, and therefore effectively solves problems existing in the prior art.

A platelet drug-loading system that targets tumors and improves radiotherapy sensitivity. The platelet drug-loading system refers to a rat platelet drug-loading system, which is a mixture of mPEG-PCL-modified atovaquone, PEG-modified nano-gold and rat platelets, namely Ato ‑Au@Plt; said targeting tumor, improving radiotherapy sensitivity The platelet drug-loading system uses platelets as a carrier to achieve long circulation in vivo and targeted release of drugs in the tumor microenvironment, and improve the radiotherapy sensitivity of tumors. The invention activates the platelet carrier through the tumor microenvironment, deforms, aggregates, and targets the tumor to release the drug; the released drug can inhibit the oxidative phosphorylation of tumor cells, solve hypoxia, and at the same time synergize with the nano-gold to improve the sensitivity of the tumor to radiotherapy , and then improve the effect of radiotherapy.

The invention discloses a radiotherapy body position fixing device, and belongs to the technical field of medical instruments. The radiotherapy body position fixing device comprises: a horizontal plate, wherein the middle of the top face of the horizontal plate is fixedly connected with the bottom face of a vertical plate, and the side face of the vertical plate in the thickness direction coincides with the side face of the horizontal plate; and a fixing structure which comprises two supporting plates, wherein the two supporting plates are arranged on the left side and the right side of the vertical plate in the thickness direction in an inverted splayed shape, the ends of the supporting plates are fixedly connected to the top face of the horizontal plate. Block bodies are fixedly connected to the opposite surfaces of the two supporting plates, arc plates are arranged in the directions, away from the ends, close to each other, of the vertical plate and the two supporting plates, of the block bodies, and the inner arc surfaces of the arc plates are close to the block bodies. The chest wall of the patient is ensured to be stretched consistently due to the fixation of the arm, the activity error of each treatment is avoided, the radiotherapy accuracy is improved, and the problem of radioactive injury to normal organs caused by treatment is reduced.