Broad-spectrum antitumor drug as well as preparation method and application thereof

Abstract

The invention is suitable for the technical field of medicines, and provides a broad-spectrum antitumor drug as well as a preparation method and an application thereof. The antitumor drug comprises the following components in parts by weight of 10-50 parts of ethylenediamine tetraacetic acid, 10-50 parts of hydroxamic acid, 10-40 parts of suberoylanilide hydroxamic acid, and 5-25 parts of deferasirox. According to the antitumor drug provided by the invention, through compounding of several components, Fe2+ and Mg2+ can be chelated, the activity of Fe2+ in key enzymes in an oxidative respiratory chain is effectively inhibited, electron transfer in the oxidative respiratory chain is inhibited, oxidative phosphorylation is inhibited, generation of ATP is inhibited, and the activity of Mg2+ inprotease is inhibited; the anabolism of purine nucleotide and pyrimidine nucleotide, the synthesis of DNA and the synthesis of protein are effectively inhibited, so that the aims of promoting the death of tumor cells and inhibiting the proliferation of the tumor cells are achieved, and the drug is a broad-spectrum and high-efficiency tumor treatment drug.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a broad-spectrum antitumor drug and its preparation method and application. Background technique [0002] According to pathological studies, tumors are new organisms or masses formed by the abnormal proliferation of local tissue cells under the long-term action of various pathogenic factors. This abnormal proliferation is a monoclonal proliferation of tumor cells. The essence of tumorigenesis is that cells lose the normal regulation of proliferation, differentiation and apoptosis at the genetic level, which is the result of disordered regulation of cell proliferation, differentiation and apoptosis. The characteristics of tumor proliferation are as follows: generally monoclonal proliferation. The tumor cell population of a tumor is a progeny tissue produced by the continuous division and reproduction of a cell that has undergone tumor transformation. This group of c...

AI Technical Summary

Problems solved by technology

However, the current anti-tumor drugs have problems such as poor inhibition of tumor cell proliferation and poor promotion of tumor cell death. Therefore, it is urgent to improve the existing anti-tumor drugs