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Structure of radioactive micro balls and preparation method

A radioactive and microbead technology, applied in the field of microbeads, can solve the problems of limited application range, large volume, radiation, etc., and achieve the effect of improving therapeutic benefit, promoting apoptosis, and reducing damage

Inactive Publication Date: 2010-06-30
李树义
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The disadvantages of radioactive particle therapy for tumors are: silver rods are used as isotope carriers and titanium tubes are used as seals to permanently introduce silver and titanium metal foreign bodies into the human body. The volume is large and the application range is limited; it cannot be used for oral or intravenous injection. Isotopes; it is difficult to repeat treatment for tumors at the same site, and the cost is high
But if the isotopic material on the surface falls off, this can expose other parts of the body to unwanted radiation
In addition, the technology of packaging isotopes on the surface of microbeads is complicated and not easy to apply and promote

Method used

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  • Structure of radioactive micro balls and preparation method
  • Structure of radioactive micro balls and preparation method
  • Structure of radioactive micro balls and preparation method

Examples

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preparation example Construction

[0036] Preparation of radioactive microbeads: 1. Place the microbeads containing phosphorus or yttrium in the irradiation container of the atomic reaction device, and the neutrons attack the microbeads to activate the phosphorus or yttrium into radioactive phosphorus ( 32 P) or radioactive yttrium ( 90 Y). The dose of irradiation is: 5×10 11 neutron / meter 2 / second, the time is 24 hours. 32 P or 90 The radioactive intensity of Y is measured with a portable isotope measuring instrument. In order to ensure the accuracy and reliability of the radioactive intensity of radioactive microbeads, it should be measured with a portable isotope measuring instrument at the same time. 32 P or 90 The radioactive intensity of the Y standard, with 32 P or 90 The radioactivity of the Y standard was normalized to that of the freshly prepared radioactive microbeads. According to the measured radioactive intensity, it is adjusted and packaged into finished radioactive microbeads with a de...

example 1

[0039] Example 1: Under the guidance of imaging equipment such as B-ultrasound, X-ray apparatus, or CT, radioactive microbeads are introduced into the tumor site by using a medical catheter. The route of introduction can utilize the arterial system or the venous system (eg, liver cancer, lung cancer, kidney cancer). Or through the digestive tract (such as gallbladder cancer, pancreatic cancer, colon and rectal tumors).

example 2

[0040] Example 2: Use of laparoscopy to assist in introducing radioactive microbeads into tumor sites (such as thoracic and abdominal tumors, uterus, bladder and prostate tumors).

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Abstract

The invention relates to the structure of radioactive micro balls and a preparation method. At least one micro ball having isotopes which can radiate beta or gamma-ray is added in a biocompatible substance; and the biocompatible substance represents biological materials and chemical materials which can be used for the clinical cure: biologic glass, biologic ceramics, biologic resin and liposome, etc. The preparation method comprises the steps: 1. activation method: putting phosphorus or yttrium-containing into an irradiation container of an atom reacting device, and irradiating the micro balls with neutron, so that the phosphorus or the yttrium is activated to be radioactive phosphorus (32P) or radioactive yttrium (90Y); and 2. mixing method: mixing isotope (such as 125I and 103Pd) which has radiate beta or gamma- ray with entitative or hollow micro balls, carrying the isotopes into human bodies by taking the micro balls as the carrier of the isotope for the radiotherapy of tumor. The radioactive micro balls have the volume which is in the range of nanometer and micrometer, and can release beta or gamma ray; and the isotope is one or several, has short radiation range, reduces the side effects of the radiotherapy of the tumor, and can be induced into the human bodies by means of local intervention or surgery through blood vessels.

Description

technical field [0001] The present invention relates to a microbead for tumor and cancer treatment, in particular to a structure and a preparation method of a radioactive microsphere for tumor and cancer treatment. technical background [0002] In recent years, radioactive seed (Radioactive seed) treatment of tumors has developed rapidly. Commonly used radioactive particles 125 Particle I is made of a titanium tube with a length of 4.5 millimeters (mm) and a diameter of 0.8 millimeters (mm). 125 I'm a silver rod. It can radiate gamma rays, and each particle contains a radiation dose of 0.4-1.0 mCi (average 0.6 mCi). The half-life is 59.4 days, and it takes 240 days to release 94% of the radiation dose. This new technology has been used in the treatment of prostate cancer, cervical cancer, osteosarcoma, head and neck tumors, pancreatic cancer, liver cancer, lung cancer, mediastinal tumors, etc. There are three implantation methods for radioactive seeds to treat tumors: 1....

Claims

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Application Information

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IPC IPC(8): A61K51/12A61P35/00
Inventor 李树义李树森李树昌李倩马捍东
Owner 李树义
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