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Application of antibacterial peptide PD-L4 in inhibition of avian influenza virus

A PD-L4 and avian influenza virus technology is applied in the application field of antibacterial peptide PD-L4 in inhibiting avian influenza virus to achieve the effect of reducing titer, reducing the number of deaths and inhibiting H9N2 subtype avian influenza virus

Active Publication Date: 2020-05-05
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no research on the effect of antimicrobial peptide PD-L4 on H9N2 avian influenza virus

Method used

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  • Application of antibacterial peptide PD-L4 in inhibition of avian influenza virus
  • Application of antibacterial peptide PD-L4 in inhibition of avian influenza virus

Examples

Experimental program
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Effect test

Embodiment 1

[0012] Application of an antimicrobial peptide PD-L4 in inhibiting avian influenza virus

[0013] 1. Materials

[0014] Antimicrobial peptide PD-L4 storage solution: According to the nucleotide sequence of antimicrobial peptide PD-L4 shown in SEQ ID NO.1, the antimicrobial peptide PD-L4 was synthesized by a biological company, wherein the amino acid sequence of antimicrobial peptide PD-L4 is as follows Shown in SEQ ID NO.2.

[0015] Antimicrobial peptide PD-L4 working solution: Add 348 μL of normal saline to each tube of antimicrobial peptide PD-L4 storage solution (11 μL).

[0016] Avian influenza H9N2 subtype virus strain (AIV); 9-day-old SPF chicken embryos.

[0017] 2. Experimental method

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Abstract

The invention provides application of an antibacterial peptide PD-L4 in inhibition of an avian influenza virus. The avian influenza virus is an H9N2 subtype avian influenza virus. After the H9N2 subtype avian influenza virus is subjected to action of the antibacterial peptide PD-L4 in vitro, SPF chick embryos are inoculated against the H9N2 subtype avian influenza virus, the number of chick embryodeaths obviously decreases, the HA titer of embryo juice also obviously decreases, that is to say, the antibacterial peptide PD-L4 can effectively inhibit the H9N2 subtype avian influenza virus.

Description

technical field [0001] The disclosure belongs to the technical field of animal immunity and the technical field of biomedicine, and specifically relates to the application of an antimicrobial peptide PD-L4 in inhibiting avian influenza virus. Background technique [0002] The H9N2 avian influenza virus (AIV) belongs to the family Orthomyxoviridae and the genus Orthomyxovirus; the virus particles are mostly spherical, with a diameter of 80-120 nanometers, and the surface is covered with dense spikes or fibrils with a length of 10-12 nanometers. , including hemagglutinin (HA) and neuraminidase (NA) surface spikes of two different shapes, and a helical nucleocapsid in the viral envelope. H9N2 avian influenza has brought huge losses to the chicken industry. The disease not only causes respiratory diseases in chickens, but also affects the reproductive system of chickens, resulting in slow growth of broiler chickens and decreased egg production of laying hens. At the same time, i...

Claims

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Application Information

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IPC IPC(8): C07K14/415A61K38/16A61P31/16
CPCC07K14/415A61P31/16A61K38/00
Inventor 张济培李巨浪陈济铛张溢珊陈建红
Owner FOSHAN UNIVERSITY
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