An ion mobility spectrometer-time-of-flight mass spectrometer

A technology of time-of-flight mass spectrometry and ion mobility spectrometry, which is applied in the field of mass spectrometry instruments, can solve problems such as affecting ion utilization efficiency, and achieve the effects of improving ion utilization efficiency and instrument detection sensitivity, shortening acquisition time, and improving analysis speed.

Active Publication Date: 2020-12-01
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

The introduction of the second-level ion gate needs to divide the ions in one IMS cycle into small ion slices according to the order of migration time. Each IMS cycle can only allow a small portion of ion slices to enter the TOFMS for detection, and the rest of the ions will be opened. It is lost on the ion gate, which will greatly affect the utilization efficiency of ions. It takes a long time to accumulate and complete a sample test to obtain the two-dimensional spectrum data of migration spectrum-mass-to-charge ratio

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  • An ion mobility spectrometer-time-of-flight mass spectrometer
  • An ion mobility spectrometer-time-of-flight mass spectrometer
  • An ion mobility spectrometer-time-of-flight mass spectrometer

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Embodiment 1

[0042] One of the time-of-flight mass analyzers of the present invention is an ion mobility spectrometer-time-of-flight mass spectrometer with a linear structure, see figure 2 shown. The microchannel plate detector and the acceleration zone are respectively arranged on two sides of the field-free flight zone away from each other. The time delay Dt of the pulse signal rising edge of the pulse voltage Ucard relative to the pulse signal falling edge of the pulse voltage Ugate is 50μs; The rising edge of the first synchronous pulse signal of the pulse voltage Upulse is delayed Dt by 50 μs relative to the falling edge of the pulse signal of the pulse voltage Ugate. The pulse signal period Tg of the pulse voltage Ugate is 10 milliseconds, and the pulse width Wg is 200 microseconds; the pulse signal period Tp of the pulse voltage Upulse is 30 microseconds, and the pulse width Wp is 5 microseconds; the pulse signal period Tc of the pulse voltage Ucard is 10 milliseconds, the pulse ...

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Abstract

The invention relates to a mass spectrometry instrument, in particular to an ionic migration spectrometry-flight time mass spectrometer, and the mass spectrometer comprises an ionic migration spectrometry cavity, a mass spectrometry transmission area cavity, a mass analyzer cavity and a data acquisition card; an ionization source, an ion gate and an ion migration region electrode are sequentiallyarranged in the ionic migration spectrometry cavity from top to bottom; a repulsion polar plate, a flight time mass analyzer and a micro-channel plate detector are arranged in the mass analyzer cavity; pulse voltages Ugate, Upulse and Ucard are respectively applied to acquisition trigger terminals of the ion gate, the repulsion polar plate and the acquisition card; and the pulse voltage Upse and the pulse voltage Ucard are synchronized based on the rising edge or falling edge moment of the pulse signal of the pulse voltage Ugate. The ionic migration spectrometry-flight time mass spectrometer can effectively improve the utilization efficiency of ions, the two-dimensional analysis speed of ionic migration spectrometry-mass spectrometry and the detection sensitivity by synchronizing and modulating the pulse time sequences of the ion gate, the repulsion polar plate and the acquisition card.

Description

technical field [0001] The invention relates to a mass spectrometry instrument, in particular to a time-of-flight mass spectrometry instrument, in particular to an ion mobility spectrometry-time-of-flight mass spectrometry instrument. Background technique [0002] Time-of-Flight Mass Spectrometry (TOFMS) is a method that calculates the mass-to-charge ratio m / z of ions by measuring the flight time of ions in the electric field in a vacuum environment to the detector to obtain the molecular mass and realize the material Qualitative analysis mass spectrometry technology has high resolution and sensitivity, wide mass range, fast response speed in microseconds and the ability to measure the whole spectrum at the same time, so it is widely used in various fields such as environment, materials, chemical industry, and biology. However, for isomers with the same elemental composition but different structures, because their molecular weights are exactly the same, it is difficult to ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/40H01J49/26H01J49/00H01J49/10
CPCH01J49/004H01J49/10H01J49/26H01J49/40
Inventor 花磊李庆运蒋吉春李海洋
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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