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Antibacterial hydrogel based on coumarin skeleton and its preparation method and application

A technology of coumarin skeleton and hydroxycoumarin, which is applied in the direction of bacteria, can solve the problems of single function of hydrogel and cumbersome preparation process, and achieve the effects of good growth and colony formation, simple preparation process and high transparency

Active Publication Date: 2020-12-08
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of antibacterial hydrogel based on coumarin skeleton and its preparation method and application, to solve the problems of existing hydrogel with single function and complicated preparation process

Method used

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  • Antibacterial hydrogel based on coumarin skeleton and its preparation method and application
  • Antibacterial hydrogel based on coumarin skeleton and its preparation method and application
  • Antibacterial hydrogel based on coumarin skeleton and its preparation method and application

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Effect test

Embodiment 1

[0065] The preparation method of the antibacterial hydrogel based on coumarin skeleton comprises the following specific steps:

[0066] (1) Dissolve 4-hydroxymethyl-7-hydroxycoumarin in an organic solvent under the condition of anhydrous and oxygen-free and the temperature is 0°C, then add triethylamine and stir evenly at room temperature, dissolve acryloyl chloride After the organic solvent was added dropwise to the system and reacted under ice bath conditions for 1.5h, then stirred overnight at room temperature, after the reaction was complete, the pH value of the system was adjusted to neutral, dried, separated and purified to obtain coumarin-containing Skeleton photoinitiator.

[0067] (2) The active monomer is mixed with deionized water to obtain an active monomer solution, and the photoinitiator is dissolved in an organic solvent to obtain a photoinitiator solution, and the photoinitiator solution is added to the active monomer solution and mixed uniformly. Irradiate un...

Embodiment 2

[0069] The preparation method of the antibacterial hydrogel based on coumarin skeleton comprises the following specific steps:

[0070] (1) Dissolve 4-hydroxymethyl-7-hydroxycoumarin in an organic solvent under the condition of anhydrous and oxygen-free and the temperature is 0°C, then add triethylamine and stir evenly at room temperature, dissolve acryloyl chloride Add it dropwise into the system after adding an organic solvent and react under ice bath conditions for 2.5h, and then stir overnight at room temperature. After the reaction is complete, adjust the pH value of the system to neutral, dry, separate and purify, and obtain coumarin-containing Skeleton photoinitiator.

[0071] (2) The active monomer is mixed with deionized water to obtain an active monomer solution, and the photoinitiator is dissolved in an organic solvent to obtain a photoinitiator solution, and the photoinitiator solution is added to the active monomer solution and mixed uniformly. Irradiate under 40...

Embodiment 3

[0073] The preparation method of the antibacterial hydrogel based on coumarin skeleton comprises the following specific steps:

[0074] (1) Dissolve 4-hydroxymethyl-7-hydroxycoumarin in an organic solvent under the condition of anhydrous and oxygen-free and the temperature is 0°C, then add triethylamine and stir evenly at room temperature, dissolve acryloyl chloride After the organic solvent was added dropwise to the system and reacted for 2 hours under ice bath conditions, then stirred overnight at room temperature, after the reaction was complete, the pH value of the system was adjusted to neutral, dried, separated and purified to obtain a coumarin-containing skeleton photoinitiator.

[0075] (2) The active monomer is mixed with deionized water to obtain an active monomer solution, and the photoinitiator is dissolved in an organic solvent to obtain a photoinitiator solution, and the photoinitiator solution is added to the active monomer solution and mixed uniformly. The ant...

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Abstract

The invention discloses antibacterial hydrogel based on a coumarin skeleton, a preparation method and application thereof, and belongs to the technical field of hydrogel. The preparation method comprises the following steps: synthesizing a photoinitiator containing a coumarin skeleton from 4-hydroxymethyl-7-hydroxycoumarin or a derivative thereof and acryloyl chloride, and then initiating an active monomer cross-linking reaction by using the photoinitiator under an illumination condition, thereby obtaining the antibacterial hydrogel. The photo-crosslinking initiator based on the coumarin skeleton synthesized according to the invention can efficiently and quickly initiate the active monomer to form hydrogel with high transparency and certain mechanical strength, application of the photoresponsive coumarin micromolecular compound in the antibacterial material field is effectively expanded, and a new thought is provided for design synthesis and application expansion of a functional photo-crosslinking agent.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to an antibacterial hydrogel based on a coumarin skeleton and a preparation method and application thereof. Background technique [0002] Hydrogel is a polymer with a three-dimensional cross-linked network structure. Its good hygroscopicity and high water retention make it widely used in chemical industry, agriculture, medicine and other fields, especially in tissue engineering, wound Dressings, drug delivery and 3D cell culture have become research hotspots. At present, a variety of hydrogel preparation and formation methods have been reported in the literature, including supramolecular interaction gelation, electrostatic interaction gelation, and copolymerization crosslinking gelation. Generally, the hydrogel formation method based on non-covalent interaction has high requirements on the structure of the active monomer, the temperature of the system, and the pH. The hydrogel p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/56C08F222/14C08F222/22C08F2/48C08J3/075C12N1/20
CPCC08F2/48C08F220/56C08J3/075C12N1/20
Inventor 李坤于抗抗王楠余孝其
Owner SICHUAN UNIV
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