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Microneedle array for rapid transdermal delivery of protein drugs and preparation method of microneedle array

A technology of microneedle array and transdermal delivery, applied in the field of biomedicine, can solve the problems such as inability to be used for rapid drug administration, and achieve the effect of simple and convenient use

Inactive Publication Date: 2020-07-28
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This regimen is suitable for sustained drug release and cannot be used for rapid drug delivery

Method used

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  • Microneedle array for rapid transdermal delivery of protein drugs and preparation method of microneedle array
  • Microneedle array for rapid transdermal delivery of protein drugs and preparation method of microneedle array
  • Microneedle array for rapid transdermal delivery of protein drugs and preparation method of microneedle array

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preparation example Construction

[0030] The present invention also provides a method for preparing the microneedle array described in the above technical solution, comprising: alternately soaking a blank microneedle array in a protein drug solution and an anionic polyelectrolyte solution, and drying to obtain a microneedle array.

[0031] In the present invention, the concentration of the protein drug solution is preferably 1 μg / ml to 1 g / ml, and the pH value is preferably 2.5 to 4; the concentration of the anionic polyelectrolyte solution is preferably 1 μg / ml to 1 g / ml, and the pH value is Preferably it is 2.5-4. In the present invention, the isoelectric point of the anionic polyelectrolyte solution is lower than that of the protein drug solution.

[0032] In the present invention, the soaking temperature is preferably 1-37°C, more preferably 10-25°C, most preferably 15-20°C; each soaking time is preferably 10s-30min, more preferably 4-20min , most preferably 5 to 6 minutes. In the present invention, the ...

Embodiment 1

[0036]A polymethyl methacrylate microneedle array loaded with a drug-loaded layer (“insulin / poly-L-glutamic acid” layer-by-layer self-assembled film) was prepared.

[0037] The specific preparation steps are as follows: respectively dissolving insulin and poly-L-glutamic acid in glycine-hydrochloric acid buffer solution (pH=3.5) with a concentration of 1 mg / mL. The polymethyl methacrylate microneedle array (needle length 600 μm, 10×10 arrangement) was alternately soaked in the two solutions, each time for 5 min, and one cycle was one layer. The temperature of the control system is 25°C, the cycle is repeated 20 times, and the product is obtained after drying.

Embodiment 2

[0039] A polylactic-co-glycolic acid (PLGA) microneedle array loaded with a drug-loaded release layer (“Interferon α-2b / polyaspartic acid” layer-by-layer self-assembled membrane) was prepared.

[0040] The specific preparation steps are as follows: respectively dissolving the interferon α-2b and polyaspartic acid in potassium chloride-hydrochloric acid buffer solution (pH=3.5), both of which have a concentration of 0.5 mg / mL. The PLGA microneedle array (needle length 700 μm, 15×15 arrangement) was alternately soaked in the two solutions, each time for 4 minutes, and one cycle was one layer. Control the temperature of the system at 20°C, repeat the cycle 15 times, and dry it.

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Abstract

The invention provides a microneedle array for rapid transdermal delivery of protein drugs and a preparation method of the microneedle array, and belongs to the technical field of biomedicine. The structure of the microneedle array comprises a microneedle array substrate and a drug-loaded release layer deposited on the surface of a microneedle, and the drug-loaded release layer consists of a layer-by-layer self-assembled film formed by electrostatic interaction of the protein drugs and anionic polyelectrolyte. The microneedle array prepared by the method is simple and convenient to use, the application time is short and is only 10 seconds to 1 minutes, the microneedle array is taken away after application, self-administration of a patient is facilitated, the microneedle array has the advantages of being minimally invasive and painless, and compliance of the patient can be improved. The drugs are released quickly, and pharmacokinetics and pharmacodynamics equivalent to those of common subcutaneous injection can be obtained.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a microneedle array for rapid transdermal delivery of protein drugs and a preparation method thereof. Background technique [0002] Patients with many diseases require frequent injections or infusions of protein drugs to treat or relieve symptoms. Traditional subcutaneous injections can cause pain, reduce patient compliance, and easily cause local adverse reactions; at the same time, protein drugs are easily degraded and difficult to absorb in the digestive system, so they are not suitable for oral administration; and because protein drugs With higher molecular weight and strong hydrophilicity, the efficiency of traditional transdermal and transmucosal drug delivery is extremely low. In the past two decades, the study of microneedle transdermal drug delivery has made great progress, which is expected to replace the traditional injection drug delivery method. Mic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K9/70A61K47/34A61K47/36A61K38/28A61K38/21A61K38/38
CPCA61M37/0015A61K9/0021A61K47/34A61K47/36A61K38/28A61K38/212A61K38/38A61M2037/0046A61M2037/0053
Inventor 张拥军王远鹏关英
Owner NANKAI UNIV
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