Application of sphingosine kinase 1 inhibitor in preparation of medicine for preventing and/or treating secondary brain injury after cerebral hemorrhage
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
- Publication Date
- 2020-07-31
Smart Images
Figure 1 
Figure 2 
Figure 3
Abstract
Description
technical field
[0001] The invention relates to the application of a sphingosine kinase 1 inhibitor in the preparation of a drug for preventing and / or treating secondary brain injury after cerebral hemorrhage, and belongs to the technical field of medicine. Background technique
[0002] Cerebral hemorrhage is a sudden-onset blood circulation disorder, clinically manifested as transient or permanent dysfunction, and is an important type of stroke. Cerebral hemorrhage deaths in the Chinese population account for about 61.7% of cerebrovascular disease deaths, and its high morbidity and mortality have become the leading cause of death for Chinese people. At present, it is believed that secondary brain injury after cerebral hemorrhage is the main injury mechanism, including neurotoxicity of red blood cell degradation products, thrombin, inflammation, edema, blood-brain barrier damage, etc. The above factors lead to cell death such as apoptosis, necrosis, and autophagy. cause irr...