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Application of indolepropionic acid in preparation of medicine for treating autism

A technology for indolepropionic acid and autism, applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc.

Active Publication Date: 2021-09-28
THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Indole propionic acid is mainly used as a pharmaceutical intermediate and plant growth hormone, and there is no report on its efficacy in treating autism

Method used

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  • Application of indolepropionic acid in preparation of medicine for treating autism
  • Application of indolepropionic acid in preparation of medicine for treating autism
  • Application of indolepropionic acid in preparation of medicine for treating autism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Mouse Model Construction embodiment Autism

[0023] Autism model 16p11.2 + / - (df / +) mice were purchased from American Laboratory Jax Lab, after propagation, the choice of 6-8 week old male df / experimental mice wild type (WT) mice and the same cage + produced.

Embodiment 2 3

[0024] Experimental Example 2 Three-social

[0025] Select the 10 healthy control WT mice in the control group, 10 males and select autism model df / + mice 8 weeks of age as the experimental group. Whether there is a social and social barriers novel social drawbacks by a three-compartment assay mouse model of autism. Three-social means is a rectangular box, the box length, width and height are 60cm, 40cm and 20cm, is divided into three interconnected chambers. First, a mouse diet of a transparent plexiglass spaced three-compartment apparatus for 10 minutes. In the second 10 minute period, the test mice can cage (empty) or genotype, age, sex matched mice (mouse 1) interact with the contact, and then, in a third 10-minute period, the only the second unfamiliar mouse (mouse 2) prior to the introduction of empty cages, such as figure 1 Indicated by A, using Etho Vision XT 10 mice were measured and recorded the package with an empty cage and the contact time of the other mice. like fi...

Embodiment 3

[0026] Experimental Example 3 Novel Object Recognition embodiment

[0027] Select the 10 healthy control WT mice in the control group, 10 males and select autism model df / + mice 8 weeks of age as the experimental group. By the novel object recognition cognitive experiments in mice. Experimental mice were acclimated in order to allow the environment, mice were placed first in the open field chambers adapt for 10 minutes, open field box length, width and height is 40cm, and then returned to the cage of mice, 24 hours after the start of the experiment, like figure 2 A shown. Start of the experiment, two identical objects is first placed in the open field chambers, mice explore freely for 10 minutes, using the recording Etho Vision XT 10 package contact time of mice two identical objects. After two hours the exploratory stage, an object is a new object substituted, mice continued to explore the object 10 minutes, the time mice sniffing direct contact with the object or objects takes...

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Abstract

The invention discloses application of indolepropionic acid in preparation of a medicine for treating autism, and relates to the technical field of new application of medicines. According to the invention, it is found that indolepropionic acid can significantly improve the autism symptom and has no obvious side effect. The indolepropionic acid can be used for developing a novel medicine for treating autism, and has wide medical prospects and economic value.

Description

Technical field [0001] Technical Field The present invention relates to a new pharmaceutical use, in particular to the use of an indole acid of a medicament for the treatment of autism. Background technique [0002] Autism (autism), also known as autism or autism disorder (autistic disorder), etc., is a pervasive developmental disorder (pervasive developmental disorder, PDD) representative disease. Children with Autism, intelligence level performance is inconsistent and small number of patients in the normal range, the majority of patients showed varying degrees of mental retardation. Began to show symptoms of autism in children before the age of 3, most of the existence of social barriers, repeat stereotyped behavior, autism tend to exhibit familial, usually considered related to heredity. Studies have shown that in the United States, the incidence of autism in children and adolescents is one of the 59 points, the Chinese autism incidence rate of 1%, the current autism spectrum ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/405A61P35/00
CPCA61K31/405A61P25/00
Inventor 李宁宁江健
Owner THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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