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Application of salmon calcitonin in preparation of drugs for treating depression

A technology for salmon calcitonin and depression, which can be applied in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve problems such as abuse potential and neurotoxicity, hindering widespread use, and hallucinogenic symptoms

Active Publication Date: 2021-03-16
THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, ketamine has many serious side effects, such as hallucinogenic symptoms, abuse potential, and neurotoxicity, etc., which hinder its widespread clinical use
[0004] Salmon calcitonin is used as a drug for the clinical treatment of osteoporosis, but there is no report on its efficacy in the treatment of depression

Method used

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  • Application of salmon calcitonin in preparation of drugs for treating depression
  • Application of salmon calcitonin in preparation of drugs for treating depression
  • Application of salmon calcitonin in preparation of drugs for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The construction of embodiment 1 depression mouse model

[0026] Male C57BL / 6J adult mice aged 8-10 weeks were purchased from Guangdong Experimental Animal Center to establish a depression model. Stressed mice are restrained in a horizontally placed 50ml cylindrical centrifuge tube (the tube has dense holes for air flow) for 2-3 hours every day, and are kept in a mouse cage for other times, and the cycle is repeated for 14 days to complete depression disease model.

Embodiment 2

[0027] Example 2 Administration of normal mice: open field experiment

[0028] Select 14 healthy 8-10 week-old male C57BL / 6J adult mice as the control group, then select 7 C57BL / 6J adult mice as the experimental group, subcutaneously inject salmon calcitonin, 5uL per gram, the concentration is 10IU / mL, and the control group was injected with the same amount of normal saline in the same way. Open field experiments were used to test voluntary movement. The mice were put into the test room and familiarized with the environment for 1 hour to reduce the tension before the test. The length, width and height of the open field are all 40cm. The open field is equally divided into 16 small grids, the middle 4 areas are considered as the middle area (20cm*20cm), and the remaining 12 grids are considered as the peripheral area. In 10 minutes, the distance the mice moved in the entire open field area and the time spent in the middle area were recorded by EthoVisionXT software. Such as...

Embodiment 3

[0029] Example 3 Administration of Normal Mice: Elevated Plus Maze

[0030] Select 15 healthy 8-10 week-old male C57BL / 6J adult mice as the control group, and then select 7 C57BL / 6J adult mice, subcutaneously inject salmon calcitonin, 5uL per gram, the concentration is 10IU / mL, control The same amount of normal saline was injected in the same way. The mice were first taken to the room to adapt for one hour, then placed in the middle area of ​​the elevated plus maze, facing the open arm, and then allowed the mice to freely explore on the elevated for 5 minutes. Such as figure 2 B, The time that normal mice spent in the open arm did not change (P=0.34).

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Abstract

The invention discloses application of salmon calcitonin in preparation of drugs for treating depression. According to the application, it is discovered that the salmon calcitonin can be used for remarkably reducing symptoms of the depression, and meanwhile, motor ability and an anxiety level are not affected. The dosage of the salmon calcitonin required for exerting a clinical drug effect is relatively small, side effects are less, and the treatment effect of the salmon calcitonin is superior to or not inferior to those of the existing therapeutic drugs, i.e., fluoxetine and ketamine. The salmon calcitonin can be developed into novel drugs for treating the depression and has important medical prospects and economic values.

Description

technical field [0001] The invention relates to the technical field of new uses of medicines, in particular to the application of salmon calcitonin in the preparation of medicines for treating depression. Background technique [0002] Depression (Major depressive disorder, MDD) is a chronic, recurrent affective disorder syndrome with life-threatening potential risks, affecting more than 20% of the population worldwide, and has become a serious public health problem. question. In recent years, with the process of global urbanization, the acceleration of people's life rhythm and the accumulation of personal life and work pressure, the incidence of depression has increased significantly year by year, seriously affecting the quality of life of individuals and the happiness and tranquility of families. The clinical manifestations of depression patients mainly include: depressed mood, decreased concentration, slow thinking, loss of appetite, weight loss, loss of interest in socia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/23A61P25/24
CPCA61K38/23A61P25/24
Inventor 李宁宁鞠俊江健王迪龙
Owner THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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