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Application of Wujiachuan cyanine dye cy5-671 in the preparation of antitumor drugs

An anti-tumor and compound technology, which is applied in the application field of the new Wujiachuan cyanine dye Cy5-671 in the preparation of anti-tumor drugs, to achieve the effect of inhibitory effect

Active Publication Date: 2021-09-28
HENAN UNIVERSITY
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  • Claims
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Problems solved by technology

The application of Cy5-671 in the preparation of anti-tumor drugs is based on the research of this research group and found that there is no research on the anti-tumor activity of this compound

Method used

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  • Application of Wujiachuan cyanine dye cy5-671 in the preparation of antitumor drugs
  • Application of Wujiachuan cyanine dye cy5-671 in the preparation of antitumor drugs
  • Application of Wujiachuan cyanine dye cy5-671 in the preparation of antitumor drugs

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Embodiment Construction

[0022] In order to make the technical objectives, technical solutions and beneficial effects of the present invention clearer, the technical solutions of the present invention will be further described below in conjunction with specific examples, but the implementation is intended to explain the present invention, and can not be interpreted as a limitation of the present invention, If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field or according to the product specification.

[0023] experimental method:

[0024] Compound preparation: Cy5-671 was dissolved in the culture medium, prepared as 1mM mother solution for later use, and the structure of Cy5-671 was identified 1 See HNMR(A) figure 1 -A, HRMS (B) data see figure 1 -B.

[0025] 1. MTT method was used to determine the inhibitory effect of Cy5-671 on the viability of colorectal cancer cell lines HCT1...

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Abstract

The invention belongs to the field of chemical industry and medicine, and relates to 1-[N-(3,5-bis(2-(2-methoxyethoxy)ethoxy)ethoxy)benzyl-2,3,3-trimethyl bromide Application of salt dye (abbreviated as Cy5‑671) in the preparation of antitumor drugs. MTT results showed that Cy5‑671 could significantly inhibit the viability of colorectal cancer cell lines HCT116 and SW480. Animal experiment results show that: Cy5‑671 significantly inhibits the growth of human colorectal cancer cell line HCT116 BALB / C nude mice subcutaneously bearing tumors, and can be used to prepare antitumor drugs. The Cy5-671 of the present invention is developed as a new type of anti-tumor drug or its auxiliary components, and has a remarkable tumor-inhibiting effect, and will provide a new treatment approach and means for treating tumors.

Description

technical field [0001] The invention belongs to the technical field of chemical industry and medicine, and in particular relates to the application of a novel Wujiachuan cyanine dye Cy5-671 in the preparation of antitumor drugs. Background technique [0002] Malignant tumors are one of the most important causes of death and the biggest obstacle to prolonging human life in the 21st century. In recent years, with the transformation of people's lifestyle and dietary structure, the incidence and mortality of tumors worldwide are on the rise, and the age of onset is younger. Although the prognosis of malignant tumor patients has been greatly improved with the application of new technologies in diagnosis and treatment and the continuous updating of chemotherapy drugs, the overall survival rate of patients has not been significantly improved. So far, although there are many methods for the treatment of malignant tumors, surgery and chemotherapy are still the main treatments. Surg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K41/0057A61P35/00
Inventor 张付利邱娜王群邹娅欣刘芳艳史霄张磊贾爽爽李娜王春丽李思颖
Owner HENAN UNIVERSITY
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