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Application of pulsatilla saponin B4 in preparation of antihypertensive drug

A technology of Pulsatilla saponin and blood pressure lowering, applied in the field of medicine

Active Publication Date: 2020-09-11
广西林洋药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pulsatilla saponin B4 is a pharmacologically active pentacyclic triterpenoid saponin extracted from the perennial herbaceous plant Pulsatilla pulsatillae, which has anti-inflammatory, antibacterial, immune regulation, anti-tumor, anti-oxidation, anti-viral and other pharmacological effects. CN 105213410 A, the application of Pulsatilla saponin B4 as an immunomodulator in the treatment of acute inflammation drugs; the publication number is CN 105535004 A, the application of Pulsatilla saponin B4 as EV71 virus inhibitor in the preparation of anti-hand, foot and mouth disease drugs, However, there is no report on Pulsatilla saponin monomer compounds that have an effect on lowering blood pressure

Method used

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  • Application of pulsatilla saponin B4 in preparation of antihypertensive drug
  • Application of pulsatilla saponin B4 in preparation of antihypertensive drug
  • Application of pulsatilla saponin B4 in preparation of antihypertensive drug

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The animal experiments on the effect of Pulsatilla saponin B4 on renal hypertension are as follows:

[0021] 1.1 Materials

[0022] 1.1.1 Experimental animals

[0023] 60 healthy male SD rats, SPF grade, body weight (180±20) g, provided by the Experimental Animal Center of Guangxi Medical University, animal qualification certificate number: SCXK Gui 2009-0002. All experimental animals were raised in a controlled environment with a room temperature of 18-24°C and a humidity of 40%-50%. During the experiment, the animals were free to eat and drink, and their circadian rhythm was normal.

[0024] 1.1.2 Main Drugs and Reagents

[0025] Pulsatilla saponin B4 (Jiangxi Bencao Tiangong Technology Co., Ltd., batch number: 2018042205); captopril (Sandoz China Pharmaceutical Co., Ltd., batch number: AK002); normal saline for injection (Sichuan Kelun Pharmaceutical Co., Ltd., Batch number: L219012211); nitric oxide detection kit (Nanjing Jiancheng Institute of Bioengineering, ba...

Embodiment 2

[0052] Animal experiments on the effect of Pulsatilla saponin B4 on spontaneous hypertension are as follows:

[0053] 2.1 Materials

[0054] 2.1.1 Experimental animals

[0055] 50 healthy male 9-week-old spontaneously hypertensive rats (SHR), 10 9-week-old male Wistar Kyoto rats (WKY), SPF grade, body weight (180±20) g, provided by the Experimental Animal Center of Guangxi Medical University , animal certificate number: SCXK Gui 2009-0002. All experimental animals were kept in a controlled environment with a room temperature of 18-24°C and a humidity of 40%-50%. During the experiment, the animals were free to eat and drink, and their circadian rhythm was normal.

[0056] 2.1.2 Main Drugs and Reagents

[0057] Pulsatilla saponin B4 (Jiangxi Bencao Tiangong Technology Co., Ltd., batch number: 2018042205); Losartan potassium tablets (Hangzhou Merck Pharmaceutical Co., Ltd., batch number: L016172); normal saline for injection (Sichuan Kelun Pharmaceutical Co., Ltd., batch numbe...

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Abstract

The invention discloses an application of pulsatilla saponin B4 in preparation of an antihypertensive drug. The pulsatilla saponin B4 has a treatment effect on hypertension, can reduce blood pressureof both renal hypertension and spontaneous hypertension and has a protection effect on hypertension and an improvement effect on the heart function.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Pulsatilla saponin B4 in the preparation of antihypertensive drugs. Background technique [0002] Abnormally elevated blood pressure is one of the main risk factors for the occurrence and development of cardiovascular diseases. Long-term elevated or unstable blood pressure can lead to serious damage to target organs such as the heart, brain, kidney, and blood vessels, and seriously affect the prognosis of the disease. Therefore, the ultimate goal of treating hypertension is to stabilize blood pressure, prevent and improve target organ damage caused by hypertension. Pulsatilla saponin B4 is a pharmacologically active pentacyclic triterpenoid saponin extracted from the perennial herbaceous plant Pulsatilla pulsatillae, which has anti-inflammatory, antibacterial, immune regulation, anti-tumor, anti-oxidation, anti-viral and other pharmacological effects. CN 1052...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P9/12
CPCA61K31/704A61P9/12
Inventor 高红伟苑仁祎坤许琼明杨世林奉建芳
Owner 广西林洋药业有限公司
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