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Enterobacteriaeae Catabacter pertinent to nephrotic syndromes, and application of enterobacteriaeae Catabacter pertinent to nephrotic syndromes

A technology for nephrotic syndrome and products, which is applied in the determination/examination of microorganisms, DNA/RNA fragments, recombinant DNA technology, etc., can solve the problems of pain and trauma of kidney biopsy patients

Pending Publication Date: 2020-09-11
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The diagnosis of nephrotic syndrome generally includes three aspects. First, confirm the diagnosis by detecting the amount of urine protein and plasma protein, then conduct a renal biopsy to make a pathological diagnosis, confirm the cause, and finally determine whether there are complications. Patient brings greater pain and trauma

Method used

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  • Enterobacteriaeae Catabacter pertinent to nephrotic syndromes, and application of enterobacteriaeae Catabacter pertinent to nephrotic syndromes
  • Enterobacteriaeae Catabacter pertinent to nephrotic syndromes, and application of enterobacteriaeae Catabacter pertinent to nephrotic syndromes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 Screening of intestinal flora associated with nephrotic syndrome

[0065] 1. Collection of samples

[0066] 1.1 Construction of membranous glomerulonephritis model

[0067] Sprague-Dawley rats were used as experimental animals, referring to the Border method (Border WA, Ward HJ, KamilES, et al. Induction of membraneous nephropathy in rabbits by administration of an exogenous cationic antigen. J Clin Invest, 1982, 69: 451-461) , using C-BSA to immunize rats to reproduce a typical and stable model of membranous glomerulonephritis.

[0068] 1.1.1 Antigen cationized BSA (C-BSA) preparation

[0069] Fraction V of natural bovine serum albumin: pure by electrophoresis, with an isoelectric point of 4.5, from Ameresco. Carbodiimide (EDC): Beijing Chemical Reagent Company. Anhydrous ethylenediamine (EDA): analytically pure, Beijing Chemical Reagent Company.

[0070] Add 500mL double-distilled water to 67mL EDA, then slowly add 350mL 6M hydrochloric acid, adjust the...

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Abstract

The invention discloses enterobacteriaeae Catabacter pertinent to nephrotic syndromes. The inventor of the invention finds that the enterobacteriaeae Catabacter is pertinent to the nephrotic syndromesfor the first time, the abundance of the enterobacteriaeae Catabacter in the nephrotic syndromes is notably reduced, which indicates that the enterobacteriaeae Catabacter can be used as a microorganism marker for diagnosing the nephrotic syndromes, and further individualized treatment is realized.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to an intestinal genus related to nephrotic syndrome, and the genus is Catabacter. Background technique [0002] Nephrotic syndrome (NS) is a group of clinical syndromes with severe proteinuria, hypoalbuminemia, hyperlipidemia and edema as its main manifestations. Threat to human health. At present, the treatment of NS mainly adopts immunosuppressant therapy, which has achieved certain curative effect. However, the prognosis of NS is closely related to the type of renal pathological changes, and the curative effect is different. Moreover, many patients develop tolerance to the above drugs, or are forced to stop the drugs due to serious adverse reactions. Finally, it develops into advanced renal failure, which brings a heavy economic burden to the patient. Therefore, it is imminent to deeply explore the pathogenesis of NS and find safe and effective therapeutic drugs. [0003] Membranou...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/158
Inventor 张森王琰张东明王伟达李昭君
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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