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Anticancer pharmaceutical composition and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of insignificant therapeutic effects of chemical drugs, easy to produce drug resistance, and large toxic and side effects, and achieve the effects of regulating tumor immune metabolism, changing the growth microenvironment, and reducing toxic and side effects

Inactive Publication Date: 2020-10-02
石小和
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the embodiments of the present invention is to provide an anti-cancer pharmaceutical composition, which aims to solve the technical problems of the existing chemical drugs for the treatment of tumors, such as insignificant therapeutic effects, large toxic and side effects, and easy drug resistance.

Method used

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  • Anticancer pharmaceutical composition and preparation method thereof
  • Anticancer pharmaceutical composition and preparation method thereof
  • Anticancer pharmaceutical composition and preparation method thereof

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preparation example Construction

[0053] The embodiment of the present invention also provides a preparation method of an anticancer pharmaceutical composition, comprising the following steps:

[0054] S10. Obtain the Chinese herbal medicine in the formula amount, pulverize it, and obtain the Chinese herbal medicine powder;

[0055] S20. Add the fermented vinegar in the formula amount to the Chinese herbal medicine powder for soaking treatment, and then stir-fry with a slow fire to obtain a stir-fried product with a slow fire;

[0056] S30. The fermented fermented unstrained spirits and vinegar paste obtained in the formula amount are added to the product stir-fried with slow fire and mixed, and then fermented to obtain a fermented product;

[0057] S40. Adding water with a ratio of 3 to 9 times the weight of raw materials to the fermentation product, extracting and processing to obtain an anti-cancer pharmaceutical composition, the anti-cancer pharmaceutical composition comprising: an anti-cancer extract and ...

Embodiment 1

[0073] An embodiment of the present invention provides an anticancer pharmaceutical composition, which specifically includes the following steps:

[0074] 1. Preparation of fermented product

[0075] 1) Mix, grind, and soak raw materials sorghum and rice, and steam the raw materials that have fully absorbed water for 120 minutes, then add 180% water of raw materials to the steamed raw materials, stew for 60 minutes, and stew at a temperature of 100°C;

[0076] 2) Grind Moutai Daqu, add 50% of the weight of the raw materials into the raw materials and mix well, then add 60% of the raw materials in water, ferment in tanks for 3 days at a fermentation temperature of 15-40°C, seal and age for 360 days after preliminary fermentation, Obtain primary fermented product;

[0077] 3) Add 150% of the weight of raw materials to the first-stage fermentation product, mix evenly, divide it into shallow tanks, cover it with straw mats, ferment for 10 days, turn it layer by layer every day, a...

Embodiment 2

[0099] An embodiment of the present invention provides an anticancer pharmaceutical composition, which specifically includes the following steps:

[0100] 1. Preparation of fermented seed grains

[0101] 1) Mix, grind, and soak the raw materials sorghum and rice, and steam the raw materials that have fully absorbed water for 180 minutes, then add 150% water by weight of the raw materials to the steamed raw materials, and stew for 30 minutes at a temperature of 100°C;

[0102] 2) Pulverize Luzhou Daqu, add 40% of the weight of the raw materials into the raw materials and mix well, then add 70% of the raw materials in water, ferment in tanks for 3 days at a fermentation temperature of 15-40°C, seal and age for 180 days after preliminary fermentation, Obtain primary fermented product;

[0103] 3) Add 120% of the raw material weight of grain leather to the primary fermentation product, mix evenly, divide it into shallow tanks, cover it with a straw mat, ferment for 15 days, and t...

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Abstract

The present invention belongs to the technical field of medicines and particularly relates to an anticancer pharmaceutical composition. The anticancer pharmaceutical composition comprises the following raw materials in parts by weight: 20-80 parts of fermented grains, 50-300 parts of fermented vinegar, 5-30 parts of vinegar paste and 49-121 parts of traditional Chinese medicinal materials. The fermented grains, fermented vinegar and vinegar paste contain polypeptides, flavone and other active substances that have an inhibitory treatment effect on tumors, also contain lactococcus, enterococcus,xanthomonas, gluconacetobacter, bacillus, lactic acid bacteria, acetic acid bacteria, aspergillus, mucor, alternaria and other microorganisms, and can ferment and process the traditional Chinese medicinal materials to produce microbial metabolic active substances and enhance medicinal properties. The provided anticancer pharmaceutical composition can reach tumor lesions and directly act on cancerous tissues, changes growth microenvironment of the tumor lesions, regulates tumor immune metabolism and inhibits tumor cell proliferation and metastasis, thereby effectively inhibiting cancer cell growth and induces apoptosis of cancer cells.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an anticancer pharmaceutical composition and a preparation method thereof. Background technique [0002] According to the World Health Organization, cancer is the second leading cause of death in the world after cardiovascular disease. In my country, the incidence of cancer has continued to rise for many years, and the incidence of cancer is close to the world level, but the mortality rate is higher than the world level. Tumor has become a public health problem and even a social problem that must be attached great importance to in our country, and China urgently needs to declare war on tumor. Lung cancer ranks first in the incidence of malignant tumors, followed by gastric cancer, colorectal cancer, liver cancer and esophageal cancer; lung cancer ranks first in death, followed by liver cancer, gastric cancer, esophageal cancer and colorectal cancer. There are few i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61K35/57A61K35/586A61K35/62A61K35/64A61K35/65
CPCA61K35/57A61K35/586A61K35/62A61K35/64A61K35/65A61K36/03A61K36/076A61K36/12A61K36/185A61K36/258A61K36/284A61K36/324A61K36/328A61K36/344A61K36/38A61K36/47A61K36/481A61K36/53A61K36/714A61K36/83A61K36/84A61K36/8905A61K36/902A61K36/9066A61P35/00A61K2300/00
Inventor 石小和
Owner 石小和
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