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Application of nattokinase to medicine for treating osteoporosis

A technology for nattokinase and osteoporosis, which is applied in the application field of nattokinase in the treatment of osteoporosis, and achieves obvious effects.

Pending Publication Date: 2020-11-03
WUHAN ZHENFU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] But the above products in the current market cannot meet people's needs gradually, therefore, it is very necessary to develop a product that can solve the above problems

Method used

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  • Application of nattokinase to medicine for treating osteoporosis
  • Application of nattokinase to medicine for treating osteoporosis
  • Application of nattokinase to medicine for treating osteoporosis

Examples

Experimental program
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preparation example Construction

[0039] Preparation of nattokinase powder: prepare Bacillus subtilis fermentation medium in a fermenter, inoculate Bacillus subtilis shake flask seed solution after sterilization, centrifuge after 22 hours of fermentation, and carry out membrane filtration and membrane concentration on the centrifuged solution to obtain a concentrated solution Spray drying is carried out to obtain nattokinase dry powder. Wherein the original seed of Bacillus subtilis Subtilisin-QK original seed batch is isolated from fermented soybean by the laboratory of Professor Wang Yefu of Wuhan University, and this bacterial classification has been preserved in the National Center for Type Culture Collection, and the bacterial classification number is CCTCCNO: M203078.

[0040] 2. Animal grouping and model making

[0041] 60 rats were randomly divided into 6 groups, 10 in each group;

[0042] High-dose group: 10 rats, within the 15th day of the test, at 10 o'clock every day, intragastric administration, ...

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Abstract

The invention discloses an application of nattokinase to a medicine for treating osteoporosis. The nattokinase is prepared by fermenting a nattokinase strain; the nattokinase used as an active component is applied to the medicine for treating osteoporosis alone or in combination with other medicines. The nattokinase has very good effects of reducing the s-TRAP value, increasing the bone mineral content, increasing mineral density and increasing calcitonin (CT), bone gla protein (BGP) and estradiol (E2), and the nattokinase can be found to have the remarkable effect of improving osteoporosis.

Description

technical field [0001] The invention relates to the field of osteoporosis treatment. More specifically, the present invention relates to the application of a kind of nattokinase in the medicine for the treatment of osteoporosis. Background technique [0002] Osteoporosis is a systemic skeletal disease characterized by systemic bone mass loss, destruction of bone tissue microstructure, decreased bone density, decreased number of trabecular bones, decreased bone strength, and susceptibility to fractures. Osteoporosis, once considered a natural consequence of aging without medical intervention, is now considered a predisposing disease that affects most older people, especially older women. Spontaneous vertebral fractures may occur in severe osteoporosis, bone loss that increases the risk of fractures, and in severe cases will affect the patient's life expectancy and quality of life. [0003] The main cause of osteoporosis: estrogen deficiency can lead to the proliferation and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K45/06A61P19/10
CPCA61K38/482A61K45/06A61P19/10C12Y304/21062
Inventor 王业富李靖董艳山高丽胡坤坤
Owner WUHAN ZHENFU PHARMA CO LTD
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