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Application of ebiprazole in the preparation of antineoplastic drugs

A technology of anti-tumor drug, ebiprazole, applied in the field of medicine

Active Publication Date: 2022-02-11
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no studies on the effect of ebiprazole on cancer, especially on esophageal cancer, gastric cancer and other tumors

Method used

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  • Application of ebiprazole in the preparation of antineoplastic drugs
  • Application of ebiprazole in the preparation of antineoplastic drugs
  • Application of ebiprazole in the preparation of antineoplastic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Materials and Methods

[0026] 1. Materials

[0027] Esophageal squamous cell carcinoma cells KYSE150, KYSE450 and gastric cancer cells HGC27, AGS were from the Department of Pathophysiology, School of Basic Medicine, Zhengzhou University

[0028] 1.1 Cell line: KYSE150 cell line, the cell line uses 1640 medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0029] KYSE450 cell line, the cell line uses DMEM medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0030] HGC27 cell line, the cell line uses 1640 medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0031] AGS cell line, the cell line uses F12K medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0032] Culture method: Culture in 8ml-10ml culture medium in a petri dish with a diameter of 10cm, and change t...

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PUM

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Abstract

The invention discloses the application of ebiprazole in the preparation of antineoplastic drugs, ebiprazole, chemical name: 7-[4-(benzo[B]thiophene-4-1-piperazine)butoxy]-2 (1H)-Quinolinone, CAS No. 913611-97-9, molecular formula C 25 h 27 N 3 o 2 S, the molecular weight is 433.57. The antitumor drug is a drug for treating esophageal cancer or gastric cancer. This application has proved through experiments that ebiprazole can inhibit the growth of esophageal squamous cell carcinoma cells or gastric carcinoma cells and transformation, and the appropriate concentration of ebiprazole to inhibit the proliferation and transformation of esophageal squamous cell carcinoma cells or gastric cancer cells is 2.5 μM to 10 μM.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of ebiprazole in the preparation of antitumor drugs. Background technique [0002] One of the defining features of cancer is the rapid production of abnormal cells that grow beyond normal limits and are thus able to invade adjacent parts of the body and spread to other organs. Symptoms of early gastric cancer are non-specific, while advanced gastric cancer often has typical clinical manifestations, endoscopic diagnosis is not difficult, but the 5-year survival rate is significantly lower than that of early gastric cancer. Given that the occurrence and development of esophageal cancer and gastric cancer is a multi-step process from chronic inflammation-dysplasia-tumor, which takes a long time, chemoprevention has a direct impact on the occurrence of tumors. [0003] Cancer is the result of the synergistic effect of environment, diet, lifestyle and genetic facto...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61P35/00
CPCA61K31/496A61P35/00
Inventor 刘康栋董子钢韦亚星赵继敏赵四敏江亚南董子明
Owner ZHENGZHOU UNIV
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