Application of ebiprazole in the preparation of antineoplastic drugs

A technology of anti-tumor drug, ebiprazole, applied in the field of medicine

CN111920814BActive Publication Date: 2022-02-11ZHENGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2022-02-11

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Abstract

The invention discloses the application of ebiprazole in the preparation of antineoplastic drugs, ebiprazole, chemical name: 7-[4-(benzo[B]thiophene-4-1-piperazine)butoxy]-2 (1H)-Quinolinone, CAS No. 913611-97-9, molecular formula C 25 h 27 N 3 o 2 S, the molecular weight is 433.57. The antitumor drug is a drug for treating esophageal cancer or gastric cancer. This application has proved through experiments that ebiprazole can inhibit the growth of esophageal squamous cell carcinoma cells or gastric carcinoma cells and transformation, and the appropriate concentration of ebiprazole to inhibit the proliferation and transformation of esophageal squamous cell carcinoma cells or gastric cancer cells is 2.5 μM to 10 μM.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the application of ebiprazole in the preparation of antitumor drugs. Background technique

[0002] One of the defining features of cancer is the rapid production of abnormal cells that grow beyond normal limits and are thus able to invade adjacent parts of the body and spread to other organs. Symptoms of early gastric cancer are non-specific, while advanced gastric cancer often has typical clinical manifestations, endoscopic diagnosis is not difficult, but the 5-year survival rate is significantly lower than that of early gastric cancer. Given that the occurrence and development of esophageal cancer and gastric cancer is a multi-step process from chronic inflammation-dysplasia-tumor, which takes a long time, chemoprevention has a direct impact on the occurrence of tumors.

[0003] Cancer is the result of the synergistic effect of environment, diet, lifestyle and genetic facto...

Examples

Embodiment

[0025] Materials and Methods

[0026] 1. Materials

[0027] Esophageal squamous cell carcinoma cells KYSE150, KYSE450 and gastric cancer cells HGC27, AGS were from the Department of Pathophysiology, School of Basic Medicine, Zhengzhou University

[0028] 1.1 Cell line: KYSE150 cell line, the cell line uses 1640 medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0029] KYSE450 cell line, the cell line uses DMEM medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0030] HGC27 cell line, the cell line uses 1640 medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0031] AGS cell line, the cell line uses F12K medium containing 10% FBS, 37 ℃ constant temperature, 5% CO 2 Cultivate and reserve under conditions.

[0032] Culture method: Culture in 8ml-10ml culture medium in a petri dish with a diameter of 10cm, and change t...