Anti-scar biomaterial, preparation method and use thereof

A biomaterial and scar technology, which is applied in the field of biomedical materials, can solve the problems of hypertrophic scar treatment without particularly effective and mature methods, and the treatment effect is not ideal, so as to achieve the goal of inhibiting scar hyperplasia, good healing effect, and adjustable strength Effect

Active Publication Date: 2022-08-02
PLASTIC SURGERY HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, there is no particularly effective and mature method for the treatment of hypertrophic scars, and the treatment effect is not satisfactory

Method used

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  • Anti-scar biomaterial, preparation method and use thereof
  • Anti-scar biomaterial, preparation method and use thereof
  • Anti-scar biomaterial, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1.1 Preparation of anti-scar biomaterials:

[0041] 1) Weigh 500mg of GW2580 solid powder with an electronic balance and place it in a 15ml sterile centrifuge tube.

[0042] 2) Pipette 5ml of VitroGel 3D-RGD hydrogel and transfer to the above centrifuge tube.

[0043] 3) Fully shake on a vortex shaker for 10 minutes, and mix until it becomes gelatinous.

[0044] 4) Store in a refrigerator at 4°C for later use. The solid diagram of the anti-scar biomaterial is shown in figure 1 .

[0045] 1.2 Anti-scar biomaterial for scarring in rat tail

[0046] Subjects: 15 SPF male Balb / c mice aged 7-11 weeks, weighing 19-22 g, were selected and divided into 3 groups on average.

[0047] Hypertrophic scar model construction and application of anti-scar biomaterials for treatment:

[0048] 1) At a dose of 50 mg / kg, mice were intraperitoneally injected with 1% sodium pentobarbital. After the onset of anesthesia, the skin was disinfected with iodophor, and a sterile towel was sprea...

Embodiment 2

[0064] 2.1 Preparation of anti-scar biomaterials:

[0065] Same as 1.1 in Example 1

[0066] 2.2 Anti-scar biomaterials used for scarring in rabbit ears

[0067] Subjects: 15 male New Zealand white rabbits aged 10-14 weeks, weighing 2-3kg, were divided into 3 groups on average.

[0068] Hypertrophic scar model construction and application of anti-scar biomaterials for treatment:

[0069] 1) Weigh an appropriate amount of urethane crystals, put them into a measuring bottle, and add an appropriate amount of double distilled water to it to prepare a 20% urethane solution for later use.

[0070] 2) Take male New Zealand white rabbits and inject 20% urethane solution into the ear vein at a dose of 5ml / kg.

[0071] 3) After the anesthesia was stabilized, iodophor was used to carefully disinfect the inner and outer surfaces of both ears 3 times. Lay sterile sheets.

[0072] 4) Drill holes on the inner surface of bilateral rabbit ears with a circular trephine. After drilling thro...

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Abstract

The invention provides an anti-scar biomaterial, a preparation method and use thereof, and relates to the technical field of biomedical materials. The material includes polysaccharide hydrogel and small molecule compound CSF1-R inhibitor. The anti-scar biomaterial of the invention can effectively inhibit the formation of hypertrophic scar and improve the curative effect of clinical tissue healing.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an anti-scar biomaterial, a preparation method and uses thereof. Background technique [0002] Drug sustained-release system, also known as drug controlled-release system, uses a certain material as a carrier to make the drug release slowly in the body at a certain speed within the required time range according to the designed dose, so as to achieve the purpose of more effective treatment of diseases. . The advantages of using a drug sustained-release system for drug delivery are: (1) Avoid the influence of drug concentration in plasma with the time of drug administration and the patient's ability to ingest, absorb and eliminate drugs, and can be released at a constant rate, or by responding to environmental changes (magnetic field, electric field). , pH value, blood sugar, etc.) release the drug in a pulsed manner to keep the drug concentration in the plasma unchan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K31/505A61P17/02
CPCA61K9/06A61K9/0014A61K47/36A61K31/505A61P17/02
Inventor 肖苒邱道静欧阳龙杨志岗傅歆
Owner PLASTIC SURGERY HOSPITAL CHINESE ACAD OF MEDICAL SCI
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