Chemotherapy pharmaceutical composition and application thereof

A chemotherapeutic drug and composition technology, applied in the field of biomedicine, can solve the problems of drug resistance, epirubicin is prone to adverse reactions, and epirubicin has limited curative effect.

Active Publication Date: 2021-01-29
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention intends to provide a chemotherapeutic drug composition to solve the technical problems that epirubicin has limited curative effect and cancer patients are prone to adverse reactions and drug resistance after long-term use of epirubicin

Method used

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  • Chemotherapy pharmaceutical composition and application thereof
  • Chemotherapy pharmaceutical composition and application thereof
  • Chemotherapy pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]A chemotherapeutic drug composition of this scheme is composed of stephentan and epirubicin, more specifically, the drug combination includes stephentan and the chemotherapeutic drug epirubicin. See formula (I) for the structural formula of stephentanin and formula (II) for the structural formula of epirubicin.

[0036]

[0037]After understanding that the drug combination provided by the present invention can improve curative effect and reduce adverse reactions, when the drug combination of the present invention is used to avoid drug resistance or drug resistance, for those skilled in the art, it is fully capable of targeting specific malignancies. Tumor, only through limited routine tests, determine the ratio of the two components of stephentan and epirubicin. For several malignant tumor cells selected during the experimental verification of the present invention, it is advisable for the drug combination to adopt such a ratio. In a course of treatment, the total amount of cephalot...

experiment example 1

[0044]Experimental example 1: Cell experiment

[0045]1. Cell selection and active culture

[0046]Experimental choices include human breast cancer cells MDA-MB-231, MCF-7, BT549, human leukemia cells K562, U937, human gastric adenocarcinoma cells SGC-7901, human lung cancer cells A549, and human esophageal cancer cells Eca109. Among them, human breast cancer cells MDA-MB-231, MCF-7, BT549 cells, human gastric adenocarcinoma SGC-7901 cells, and human lung cancer A549 cells were cultured in DMEM+10% FBS complete medium; human leukemia cells K562, U937 The cells, human esophageal cancer cells Eca109 were cultured in RPMI1640+10% FBS complete medium. The above cells are all at 37℃, 5% CO2, Cultivate in a cell incubator with saturated humidity.

[0047]2. Experimental methods and results

[0048]After the status of each tumor cell line is stable, the cells are plated in a 96-well plate with 5000 cells per well, each well containing 90 μL of complete medium, and then the cells are treated with drugs...

experiment example 2

[0073]Experimental example 2: Nude mice transplanted tumor model experiment (only transplanted human breast cancer MDA-MB-231 cells as an example)

[0074]During this experiment, various drugs were injected into nude mice through the abdominal cavity for comparison (that is, not through intravenous injection).

[0075]1. The choice of nude mice

[0076]Twenty-four SPF-free nude mice aged 6-8 weeks with a weight range of 20±2g were raised at room temperature (20℃~23℃) in an alternate day and night environment with free drinking and eating.

[0077]2. Experimental grouping and dosage (4 groups in total)

[0078]All nude mice were randomly divided into four groups, each with 6 mice, and each right thigh was inoculated with 1×1070.2 mL of a suspension made of human breast cancer MDA-MB-231 cells (culture of human breast cancer MDA-MB-231 cells is the same as the aforementioned "cell experiment"), after the tumor is formed, start the administration in the following manner.

[0079](1) Control group: intra...

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PUM

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Abstract

The invention relates to the technical field of biological medicine, in particular to a chemotherapy pharmaceutical composition and application thereof. The invention relates to a chemotherapy pharmaceutical composition, which comprises cepharanthine and epirubicin. Before epirubicin is administrated, cepharanthine is administrated firstly, and the cancer cell inhibiting effect of epirubicin can be synergistically enhanced. According to the scheme, the technical problems that the curative effect of epirubicin is limited, and adverse reactions and drug resistance are easily generated when a cancer patient uses epirubicin for a long time are solved. The composition can be applied to clinical practices of treatment of various cancers, reduces adverse reactions of epirubicin, and prevents drugresistance of epirubicin at the same time.

Description

Technical field[0001]The invention relates to the technical field of biomedicine, in particular to a chemotherapeutic drug composition and its application.Background technique[0002]Chemotherapy is one of the methods for the treatment of malignant tumors (cancer). It is a treatment that uses chemical drugs to prevent the proliferation, infiltration, and metastasis of cancer cells, and ultimately kill the cancer cells. Epirubicin (Epirubicin) is also called epirubicin. Compared with Doxorubicin, it has higher curative effect but less toxicity to the heart. It is currently one of the chemotherapeutic drugs in clinical application. Clinically, epirubicin injection is used to treat breast cancer, ovarian cancer, gastrointestinal cancer (such as advanced gastric cancer, advanced rectal cancer), malignant lymphoma, lung cancer, and malignant melanoma. However, epirubicin is the same as other chemotherapeutic drugs. Due to its low selectivity, it will inevitably damage the normal cells of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P35/00A61K31/4741
CPCA61K31/4741A61K31/704A61K9/0019A61P35/00A61K2300/00
Inventor 高宁姜秀星龚其海李志强申立文王梅
Owner ZUNYI MEDICAL UNIVERSITY
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