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An anti-anxiety/anti-depressant medicinal composition and its application

A composition and anti-anxiety technology, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve the problems of anti-anxiety/anti-depressant drug adverse reactions and poor effects, and achieve dosage reduction, cost reduction, and safety sex high effect

Active Publication Date: 2021-03-23
HEMPIRE (SHANGHAI) PHARM R&D LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to solve the problem of serious adverse reactions or poor effects of existing anti-anxiety / anti-depressant drugs, and to provide a pharmaceutical composition. Act synergistically with significant antidepressant and / or anxiolytic effects

Method used

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  • An anti-anxiety/anti-depressant medicinal composition and its application
  • An anti-anxiety/anti-depressant medicinal composition and its application
  • An anti-anxiety/anti-depressant medicinal composition and its application

Examples

Experimental program
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Effect test

preparation example Construction

[0037] Preparation of the refined cannabis extract of the test drug: take industrial hemp flowers and leaves, extract them with ethanol, and molecularly distill the cannabis extract, then collect cannabidiol, tetrahydrocannabinol, and cannabinol in sections through high-pressure preparation chromatography, and then three The main ingredients are crystallized to prepare pure products, namely CBD (99.84%), THC (99.32%) and CBN (99.02%).

[0038] 2.1.1 Preparation of test liquid:

[0039] Preparation of CBD sub-microemulsion: Weigh 25g of glycerin and dissolve it in 500ml of water for injection, weigh 12g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.0943g of CBD crystals and dissolve it in 100g In coconut oil, add 2g of oleic acid and mix well to obtain a CBD oil solution; add the CBD oil solution into a high-shear emulsifier at a constant speed to prepare a fat emulsion solution, and ...

Embodiment 1-3 and comparative example 1-4

[0064] Weigh 250g of glycerin and dissolve it in 5000ml of water for injection, weigh 120g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.3765g of CBD crystals, 0.0063g of THC crystals, and 0.0126g of CBN crystals Dissolve in 1000g (300g sweet almond oil, 300g coconut oil, 400g linseed oil) mixed oil, add 20g oleic acid and mix well to obtain an oil phase; add the oil phase to a high shear emulsifier at a uniform speed to prepare a fat emulsion solution , add water for injection to 10000ml, until a stable fat emulsion submicroemulsion solution is formed, filter through a microporous membrane, subpackage, and spin sterilize, as the test drug solution of Example 2, the content of CBD is 0.03759mg / ml, THC The content of CBN is 0.00063mg / ml, and the content of CBN is 0.00125mg / ml (the ratio is about 60:1:2); according to this method, other examples and comparative examples are prepared acc...

Embodiment 4-6 and comparative example 5-8

[0104] Weigh 250g of glycerin and dissolve it in 5000ml of water for injection, weigh 120g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.3765g of CBD crystals, 0.0063g of THC crystals, and 0.0126g of CBN crystals Dissolve in 1000g (300g sweet almond oil, 300g coconut oil, 400g linseed oil) mixed oil, add 20g oleic acid and mix well to obtain an oil phase; add the oil phase to a high shear emulsifier at a uniform speed to prepare a fat emulsion solution , add water for injection to 10000ml, until a stable fat emulsion submicroemulsion solution is formed, filter through a microporous membrane, subpackage, and spin sterilize, as the test drug solution in Example 5, the content of CBD is 0.03759mg / ml, THC The content of CBN is 0.00063 mg / ml, and the content of CBN is 0.00125 mg / ml (the ratio is about 60:1:2); according to this method, the test liquids of other examples and comparative exa...

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Abstract

The invention discloses an anxiolytic / antidepressant medicinal composition and its application. The active components of the medicinal composition include: 40-80 parts by weight of cannabidiol and 0.5-1.5 parts by weight of tetrahydrocannabinol , 1.3 to 2.7 parts by weight of cannabinol. In the medicinal composition provided by the present invention, the combination of different ratios of cannabis extracts can play the role of anti-anxiety, anti-depression and soothing the spirit through the interaction of drug components, and can greatly reduce the effects of cannabis extracts, especially cannabidiol. It is especially suitable for all kinds of people under the current social pressure.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an anxiolytic / antidepressant pharmaceutical composition and its application. Background technique [0002] At present, with the acceleration of the pace of life, the increase of life pressure, the number of people living alone is increasing, and the people with sleep disorders, anxiety and depression are developing from middle-aged and elderly people to younger people. People are also paying more and more attention to the impact of sub-health status on quality of life. Depressed and depressed people are the main force in sub-healthy people. [0003] Anxiety and depression are a kind of mental illness that endanger people's healthy life. At present, my country's economy is developing rapidly, social competition is fierce, and the urban population is increasing rapidly. The number of patients with anxiety and depression has increased significantly. At present, the commonly used anti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/05A61P25/22A61P25/24
CPCA61K31/05A61K31/352A61P25/22A61P25/24A61K2300/00
Inventor 邹陈东肖挽李国辉黄穗
Owner HEMPIRE (SHANGHAI) PHARM R&D LTD
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