Chimonanthus nitens leaf concentrated pills and preparation method thereof

Abstract

The invention provides Chimonanthus nitens leaf concentrated pills and a preparation method thereof. The preparation method comprises the following steps of: by taking Chimonanthus nitens leaves as araw material; extracting Chimonanthus nitens leaf volatile oil by virtue of a microwave-assisted steam distillation method; concentrating and drying an alcohol extract into an extract; concentrating and drying a water extract into clear paste powder; drying dregs obtained by filtering; grinding and then screening to obtain fine dreg powder; forming pills from the fine dreg powder, the extract andthe clear paste powder by virtue of a molding method; drying at a low temperature, thereby obtaining pills; preparing the volatile oil into a beta-cyclodextrin inclusion compound; drying; grinding into powder; covering the pills, the fine dreg powder, the inclusion compound powder and a disintegrating agent; rounding; and polishing, thereby obtaining the concentrated pills. The Chimonanthus nitensleaf concentrated pills prepared by the invention are high in content of active ingredients of the Chimonanthus nitens leaf, high in bioavailability and high in active titer. According to the preparation method disclosed by the invention, on the basis of a traditional use manner of the Chimonanthus nitens leaves, all components of the Chimonanthus nitens leaves are used, so that the concentratedpills have the advantages of being high in medicinal material availability and capable of reducing resource waste, the administration compliance of patients can be improved, and the concentrated pillshave excellent market prospects.

Description

technical field [0001] The invention belongs to the important field of research and development of traditional Chinese medicine preparations, and relates to a concentrated plum leaf pill and a preparation method thereof. Background technique [0002] Concentrated pills have a long history in my country. As early as Jin Ge Hong's "Elbow Reserve Emergency Prescription", there is a discussion of "...removing the dregs, adding the soup, and decocting Lingke pills", which describes the simple preparation method of concentrated pills. Concentrated pills refer to pills made by concentrating part of the extracts of medicinal materials into ointments and fine powders of certain medicinal materials or adding suitable excipients. Concentrated pills are small in size, easy to take, suitable for mechanized production and convenient for storage. At the same time, the content of active ingredients is higher than that of traditional tablets and granules, because it is a pill made by conce...

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Problems solved by technology

During the preparation process of the waxberry tablet, the volatile oil of the waxberry leaf is directly sprayed on the granules. Because the volatile oil of the waxberry

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