Granules for treating cold and cough and preparation method thereof

Abstract

The invention provides granules for treating cold and cough and a preparation method thereof. The preparation method comprises the following steps: taking 15-25% of prescription dosage of radix trichosanthis, crushing, and sieving with a 70-90-mesh sieve to obtain radix trichosanthis fine powder; the preparation method comprises the following steps: taking the balance of prescription dosage of medicinal materials including radix trichosanthis, honeysuckle, folium eriobotryae, radix stemonae and platycodon grandiflorum, crushing, sieving with a 30-50-mesh sieve, adding an ethanol solution, extracting, filtering, reserving dregs for later use, recovering ethanol from filtrate until no alcohol smell exists, and obtaining an extracting solution A; taking the dregs, adding a sodium hydroxide solution for ultrasonic extraction, filtering, adjusting the pH value of filtrate to be neutral by using a hydrochloric acid solution, and obtaining an extracting solution B; combining the extracting solution A and the extracting solution B, concentrating to obtain clear paste, adding the radix trichosanthis fine powder, cane sugar and dextrin, uniformly mixing, granulating and drying to obtain granules; taking eucalyptus oil, and carrying out inclusion by using hydroxypropyl-beta-cyclodextrin to obtain an inclusion complex; and taking the granules and the inclusion complex, adding talcum powder, and uniformly mixing to obtain the granules for treating cold and cough. By improving the process, the drug effect of the product is improved, the production time is shortened, energy consumption isreduced, and the cost is saved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to cold and cough granules and a preparation method thereof. Background technique [0002] The prescription of the present invention is recorded in the "Drug Standards of the Ministry of Health of the People's Republic of China" in the third volume of traditional Chinese medicine preparations "cold and cough granules". The medicine has the effects of clearing away heat and detoxification, relieving cough and reducing phlegm, and is used for cold, fever, headache and cough. The original dosage form of "Cough Granules" has been clinically used for many years, and has good clinical curative effect, with no reports of toxic and side effects. In addition to the original dosage form of "Ganmao Cough Granules", many companies have carried out research on changing dosage forms, and produced "Ganmao Cough Granules", "Cough Tablets" and "Cough Capsules". [0003] The col...

AI Technical Summary

Problems solved by technology

However, there is eucalyptus oil as a volatile component in this prescription, and eucalyptus oil is directly added in the granules, which is volatile and unstable in quality under the conditions of water, light and heat, and in the prior art, the extraction of various dosage forms of medicinal materials in this prescription The method still uses the original method. With the extensive development of basic scientific research, it is necessary to further study the active ingredients or effective parts in the medicinal materials, so as to change the original extraction and purification method or production process, so that the product can obtain better curative effect and stability

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