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A Ziyin Yikou Buccal Liquid for Treating Radiation Dry Mouth

A xerostomia and radioactive technology, applied in the field of traditional Chinese medicine, can solve problems such as difficulty in swallowing and talking, salivary gland tissue damage, oral mucosal congestion, etc., and achieve improvement of saliva-related inflammatory indicators, improvement of KPS) score, and dry mouth. Thirst reduction effect

Active Publication Date: 2022-02-08
重庆市黔江中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the treatment of malignant tumors of the head and neck, radiation therapy is generally required, but due to the location of the salivary gland and its high sensitivity to radiation, the malignant tumor cells are killed while the adjacent salivary gland tissue is also damaged. There will be varying degrees of salivary gland dysfunction or dry mouth caused by permanent loss, which will lead to a series of complications such as dental caries, fungal infection, loss of taste, difficulty in swallowing and talking, and nutritional deficiencies, which seriously affect the quality of life of patients. The prevention and treatment of xerostomia has always been the focus of domestic and foreign scholars
[0003] At present, Biafine cream is generally used to treat radiation-induced oral mucositis clinically. After smearing and gargling with the suspension, almost half of the patients will still have oral mucosa hyperemia and erythema, and even scattered ulcers and inflammatory secretions, accompanied by pain. ; can not effectively relieve the pain of patients

Method used

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  • A Ziyin Yikou Buccal Liquid for Treating Radiation Dry Mouth
  • A Ziyin Yikou Buccal Liquid for Treating Radiation Dry Mouth
  • A Ziyin Yikou Buccal Liquid for Treating Radiation Dry Mouth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Make a kind of Ziyinyikou buccal liquid for the treatment of radioactive xerostomia, take 3kg of Radix Ginseng, 3kg of Ophiopogon japonicus, 3kg of Polygonatum Polygonatum, 3kg of Pueraria radiata, 3kg of Dendrobium, 3kg of Lily, 3kg of Cucumber Fragrance, 3kg of Nine Head Lion Grass, licorice 1kg; put the above-mentioned raw materials in an extraction tank, add 100kg of distilled water, first heat to boiling with a strong fire, then change to a slow fire, keep a slight boiling state for extraction for 40 minutes, then filter, and then concentrate the filtrate to 6.25kg of concentrate, Then the concentrated solution is divided into 200 equal portions, and each equal portion is divided into one dose to obtain the nourishing yin and benefiting mouth buccal liquid.

Embodiment 2

[0030] Make a kind of Ziyinyikou buccal liquid for the treatment of radioactive xerostomia, take 5kg of Radix Ginseng, 5kg of Ophiopogon japonicus, 5kg of Polygonatum Polygonatum, 5kg of Pueraria radiata, 5kg of Dendrobium, 5kg of Lily, 5kg of Cucumber Fragrance, 5kg of Nine Head Lion Grass, licorice 2kg; put the above raw materials in the extraction tank, add 165kg of distilled water, heat to boiling with strong fire, then change to slow fire, keep the slight boiling for 50 minutes, filter, concentrate the filtrate to 21.0kg of concentrated solution, and then divide the concentrated solution into 333 equal parts, each part is divided into one dose to obtain the nourishing yin and benefiting oral liquid.

Embodiment 3

[0032] Make a kind of Ziyinyikou buccal liquid for the treatment of radioactive xerostomia, take 7kg of Radix Ginseng, 7kg of Radix Ophiopogon japonicus, 7kg of Polygonatum Polygonatum, 7kg of Pueraria Root, 7kg of Dendrobium, 7kg of Lily, 7kg of Cucumber Fragrance, 7kg of Nine Head Lion Grass, and Licorice 3kg; put the above-mentioned raw materials in the extraction tank, add 230kg of distilled water, heat to boiling with strong fire, then change to slow fire, keep the slight boiling for 60 minutes, filter, concentrate the filtrate to 44.25 kg of concentrated solution, and then divide the concentrated solution into 466 equal parts, every equal part is divided into one dose, obtains Ziyin Yikou buccal liquid.

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Abstract

A nourishing yin and beneficial oral liquid for treating radioactive xerostomia belongs to the technical field of traditional Chinese medicine. Combining, then placing each raw material in an extraction tank, adding distilled water, heating with high heat to boiling, changing to simmering fire, maintaining slight boiling for 40-60 minutes, filtering, and concentrating the filtrate to 0.25-0.75 times the total weight of the original medicinal material to make Its beneficial effects are that Sha participates in Ophiopogon japonicus as the monarch medicine, nourishing yin and moistening dryness, clearing the lungs and quenching thirst; Tujia characteristic cucumber fragrance and nine head lion grass are the minister medicines, clearing away heat and detoxifying, cooling blood and reducing swelling; Pueraria lobata, lily, Polygonatum japonica is an adjuvant, mainly clearing heat and promoting body fluid, moistening lungs and nourishing yin; licorice is used as an agent to reconcile various medicines; it can nourish yin and nourish yin for the symptoms of radioactive xerostomia, such as dry mouth, dry mouth, dry lips, and glossy tongue. Promotes body fluid, clears heat and detoxifies; greatly reduces the exudation area, ulcer area and congestion area of ​​radioactive xerostomia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, in particular to a Ziyinyikou buccal liquid for treating radiation xerostomia. Background technique [0002] In the treatment of malignant tumors of the head and neck, radiation therapy is generally required, but due to the location of the salivary gland and its high sensitivity to radiation, the malignant tumor cells are killed while the adjacent salivary gland tissue is also damaged. There will be varying degrees of salivary gland dysfunction or dry mouth caused by permanent loss, which will lead to a series of complications such as dental caries, fungal infection, loss of taste, difficulty in swallowing and talking, and nutritional deficiencies, which seriously affect the quality of life of patients. The prevention and treatment of xerostomia has always been the focus of domestic and foreign scholars. [0003] At present, Biafine cream is generally used to treat radiation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61P1/12
CPCA61K36/342A61K36/34A61K36/23A61K36/8968A61K36/8969A61K36/488A61K36/8984A61K36/8967A61K36/482A61K36/739A61K36/86A61K36/19A61K36/484A61K9/006A61P1/12A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 许美凤彭太芳谭元灿
Owner 重庆市黔江中心医院
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