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Preparation method of electrochemical sensor for detecting sepsis marker procalcitonin

A procalcitonin, electrochemical technology, applied in the direction of material electrochemical variables, scientific instruments, instruments, etc., can solve problems such as limited application, and achieve the effect of improving sensitivity, increasing specific surface area and electron transfer capacity

Active Publication Date: 2021-04-09
INNER MONGOLIA UNIV FOR THE NATITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, g-C 3 N 4 The wide bandgap limits its application in electrochemical applications

Method used

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  • Preparation method of electrochemical sensor for detecting sepsis marker procalcitonin
  • Preparation method of electrochemical sensor for detecting sepsis marker procalcitonin
  • Preparation method of electrochemical sensor for detecting sepsis marker procalcitonin

Examples

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Embodiment 1

[0035] Embodiment 1: A kind of preparation method of the electrochemical sensor that is used to detect sepsis, its preparation steps are as follows (preparation process see figure 1 ):

[0036] S1: Carbon nitride powder preparation:

[0037] 1) Place 0.25g of urea in a quartz ceramic crucible, and place it in a tube furnace to raise the temperature to 550°C at 5°C / min.

[0038] 2) keeping the quartz ceramic crucible at 550°C for 3 hours under normal pressure;

[0039] 3) After the quartz ceramic crucible is cooled to room temperature, the product in the quartz ceramic crucible is collected to prepare carbon nitride powder.

[0040] S2: Preparation of graphitic carbon nitride

[0041] 1) Weigh 0.001 g of carbon nitride powder prepared in step S1 above, and disperse it in 2 ml of ethanol (HPLC grade), and ultrasonicate the mixture for 1 h;

[0042] 2) The ultrasonically treated mixture in step 1) is left to stand until the large particles of graphite-phase carbon nitride com...

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Abstract

The invention discloses a preparation method of an electrochemical sensor for detecting sepsis marker procalcitonin. The preparation method comprises the following steps: preparing carbon nitride powder, preparing graphite-phase carbon nitride, modifying an electrode with the graphite-phase carbon nitride, and modifying the electrode with a polypeptide probe. According to the electrochemical sensor prepared in the invention, the exfoliated graphite phase carbon nitride is modified on the surface of the glassy carbon electrode, so that the specific surface area and the electron transfer capability can be increased during detection, and the polypeptide probe capable of specifically identifying procalcitonin is modified on the glassy carbon electrode, so the detection sensitivity, accuracy and characteristic selectivity of the sensor can be improved conveniently, and the detection sensitivity of the procalcitonin sensor to procalcitonin can reach 0.15 fg / mL.

Description

technical field [0001] The invention relates to the technical field of electrochemical sensors, in particular to a method for preparing an electrochemical sensor for detecting sepsis marker procalcitonin. Background technique [0002] Sepsis is a potentially fatal or life-altering syndrome in which the body's response to infection is a systemic immune response. Many people think of sepsis as having three stages, starting with sepsis and progressing to severe sepsis and septic shock. At present, about 30%-70% of sepsis patients cannot survive due to multiple organ failure. Therefore, early, timely and specific treatment of sepsis is important and clinically necessary. [0003] Procalcitonin (ProCT, proclacitonin) is a sepsis-inducible protein, which is a hormonally inactive calcitonin propeptide substance, which can be used as a marker of infectious inflammation to distinguish bacterial infection from viral Sexual infection, and to judge the severity and prognosis of bacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/327G01N27/48
CPCG01N27/308G01N27/48G01N27/3277
Inventor 刘雨双包腊月刘景海海文峰鲍文吉
Owner INNER MONGOLIA UNIV FOR THE NATITIES
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