Bending-resistant dry cardiac biovalve and preparation method thereof

A heart valve and drying technology, applied in the direction of heart valves, can solve problems such as tearing, biological valves that are difficult to eliminate folds, and mechanical strength and durability of the valves.

Active Publication Date: 2021-04-20
KOKA NANTONG LIFESCIENCES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical strength and durability of this dry valve are reduced to a certain extent, and the valve leaflets will delaminate and tear when the biological valve is subjected to fatigue tests.
The long-term bending preservation makes the bioprosthesis have wrinkles that are difficult to eliminate after rehydration

Method used

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  • Bending-resistant dry cardiac biovalve and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment provides a preparation method of a bending-resistant dry biological heart valve, such as figure 1 shown, including:

[0032] S11. Soaking the animal heart valve in glutaraldehyde solution to obtain the animal heart valve soaked in glutaraldehyde solution;

[0033] S12. Soak the obtained animal heart valve soaked in the glutaraldehyde solution in the alkylsulfonyl chloride solution to obtain the animal heart valve soaked in the alkylsulfonyl chloride solution;

[0034] S13. Dehydrating and drying the obtained animal heart valve soaked in the alkylsulfonyl chloride solution through an alcohol solution to obtain a bending-resistant biological heart valve.

[0035] In this embodiment, in order to improve the bending resistance of the valve after drying, there is still no wrinkle after a long period of pressing and folding. After cross-linking with glutaraldehyde, alkylsulfonyl chloride is added for treatment. The chlorine in the alkylsulfonyl chloride can b...

Embodiment 2

[0056] This embodiment provides a method for preparing a bending-resistant dry biological heart valve, which is different from Embodiment 1 in that:

[0057] Take fresh beef pericardium to remove the fat fiber etc. on the surface.

[0058] 1) Soak with 5% glutaraldehyde solution at room temperature for 24 hours, take it out and rinse it clean.

[0059] 2) Preparation of alkylsulfonyl chloride solution: the concentration of dodecylsulfonyl chloride is 2%, and the concentration of alkyl glycoside is 0.1%. After stirring at room temperature to form an emulsion, the pericardium is immersed, and the ratio of pericardium to liquid is 1:100.

[0060] 3) Soak in Ⅰ: 25% ethanol / 75% glycerol, Ⅱ: 50% ethanol / 50% glycerol, Ⅲ: 75% ethanol / 25% glycerol at room temperature for 24 hours to complete dehydration and drying .

[0061] The product prepared in this embodiment was subjected to a simulated folding test (after the sample was paired twice, a 10kg weight was folded for 30 days) and a...

Embodiment 3

[0063] This embodiment provides a method for preparing a bending-resistant dry biological heart valve, which is different from Embodiment 1 in that:

[0064] Take fresh beef pericardium to remove the fat fiber etc. on the surface.

[0065] 1) Soak with 5% glutaraldehyde solution at room temperature for 24 hours, take it out and rinse it clean.

[0066] 2) Prepare the alkylsulfonyl chloride solution: the concentration of dodecylsulfonyl chloride is 1%, and the alkyl glycoside is 0.05%. After stirring into an emulsion at room temperature, the pericardium is immersed in the pericardium, and the ratio of pericardium to liquid is 1:100.

[0067] 3) Soak in Ⅰ: 25% ethanol / 75% glycerol, Ⅱ: 50% ethanol / 50% glycerol, Ⅲ: 75% ethanol / 25% glycerol at room temperature for 24 hours to complete dehydration and drying .

[0068] The product prepared in this embodiment was subjected to a simulated folding test (after the sample was paired twice, a 10kg weight was folded for 30 days) and a te...

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Abstract

The invention discloses a preparation method of a bending-resistant dry cardiac biovalve. The preparation method comprises the following steps: S11, soaking an animal cardiac valve in a glutaraldehyde solution to obtain an animal cardiac valve soaked with the glutaraldehyde solution; S12, soaking the obtained animal cardiac valve soaked with the glutaraldehyde solution in an alkyl sulfonyl chloride solution to obtain an animal cardiac valve soaked with the alkyl sulfonyl chloride solution; and S13, dehydrating and drying the obtained animal cardiac valve soaked with the alkyl sulfonyl chloride solution through an alcohol solution to obtain the bending-resistant cardiac biovalve. After undergoing the technical treatment of the invention, the artificial biovalve can be preserved in a dry state, and sterilization treatment and liquid preservation with aldehydes substances are avoided, thereby effectively lowering the residual risk of the aldehydes substances.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bending-resistant dry biological heart valve and a preparation method thereof. Background technique [0002] Heart valve disease is a common heart disease in our country, among which the valve damage caused by rheumatic fever is the most common. With the aging of the population, senile valvular disease and valvular disease caused by coronary heart disease and myocardial infarction are becoming more and more common. According to the survey and statistics of current diseases, the incidence rate of heart valve disease in my country is 2.5%-3.2%. Among them, the incidence rate of valvular heart disease in the elderly over 75 years old is as high as 13.3%. Mild valvular heart disease can be treated with drugs, but in severe cases only surgery can be used to replace the valve. Traditional surgical operations require thoracotomy while requiring cardiac arrest and the e...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61F2/24
Inventor周茜吴明明陈大凯
OwnerKOKA NANTONG LIFESCIENCES CO LTD