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Anti-cancer composition containing auranofinand sulfhydryl compound and application of anti-cancer composition

A technology of sulfhydryl compounds and compositions, applied in the field of anticancer compositions containing auranofin and sulfhydryl compounds, can solve the problem that the combined anticancer effect is not disclosed, etc.

Active Publication Date: 2021-04-23
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, the combined anti-cancer effect of Auranofin and other drugs has not yet been disclosed, and the mechanism of its anti-cancer effect when combined with other drugs is of great significance for the development of anti-cancer drugs

Method used

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  • Anti-cancer composition containing auranofinand sulfhydryl compound and application of anti-cancer composition
  • Anti-cancer composition containing auranofinand sulfhydryl compound and application of anti-cancer composition
  • Anti-cancer composition containing auranofinand sulfhydryl compound and application of anti-cancer composition

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Embodiment Construction

[0057] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific implementations described in this specification are only for explaining the present invention, not for limiting the present invention.

[0058] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial channels.

[0059] Effects of Auranofin combined with various sulfhydryl compounds on the inhibitory activity of various cancer cells

[0060] (1) Culture of cancer cells

[0061]Take the culture bottle in which the cancer cells needed for the experiment were cultured, discard the original culture medium, wash three times with 2mL PBS, add 1mL trypsin to digest for 30s, and add 2mL medium to stop the digestion. Transfer the cells ...

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Abstract

The invention discloses an anti-cancer composition containing auranofin and a sulfhydryl compound and an application of the anti-cancer composition. The composition contains auranofinand the sulfhydryl compound. Through combined use of the auranofin and the sulfhydryl compound, the defect that the auranofin cannot efficiently inhibit cancer cell proliferation under normal physiological conditions is overcome. When the sulfhydryl compound is combined, the auranofin can well inhibit the growth of tumors, which shows that the combination of the auranofin and the sulfhydryl compound can be used as an anti-cancer drug combination. In addition, the absorption of the auranofin in tumor tissues can be adjusted by adjusting the types of sulfhydryl compounds, so that the auranofin has better selectivity in in-vivo cancer resistance.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to an anticancer composition containing auranofin and a mercapto compound and application thereof. Background technique [0002] Metallic drugs represented by cisplatin are important clinical anticancer drugs, but many tumors are inherently resistant to platinum drugs or develop drug resistance as the dosage increases, and patients are prone to develop Strong adverse reactions (such as bone marrow suppression, gastrointestinal reactions, renal toxicity, neurotoxicity, allergic reactions, electrolyte disturbances and liver damage), therefore, its practical application has been greatly limited. [0003] Auranofin is an oral antirheumatic drug mainly used in the treatment of active rheumatoid arthritis. In earlier studies, auranofin was effective in prolonging the lifespan of mice inoculated with acute lymphoblastic leukemia cells P388. However, follow-up studie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/7135A61K31/095A61K31/145A61P35/00
CPCA61K31/145A61K31/7135A61P35/00A61K45/06A61K31/10A61K2300/00
Inventor 邹滔滔王园熊啸林陈新滋
Owner SUN YAT SEN UNIV
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