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Stem cell preparation for cellular immunoregulation and preparation method thereof

A stem cell preparation and cellular immunity technology, applied in the field of stem cell preparations for cellular immune regulation and their preparation, can solve problems such as patient injury, lack of specific reference to stem cell preparation procedures and operating specifications, potential safety hazards of stem cell preparations, etc., and achieve simple operation. Effect

Pending Publication Date: 2021-05-11
广东善玺迦纳栗生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a stem cell preparation for cellular immunity regulation and its preparation method, which has the advantages of detailed procedures, solves the problem that there is no specific reference for the specific flow and operating specifications of the stem cell preparation in the preparation process, and provides guidance for the prepared stem cell preparation. It brings certain safety hazards and is also a kind of harm to patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0016] A method for preparing a stem cell preparation for cellular immunity regulation, comprising the following steps:

[0017] Step a: Infectious disease inspection, pregnant women should do a good physical examination before delivery, these inspections include: whether the liver function is normal, whether there is Treponema pallidum, HIV, hepatitis B virus, hepatitis C virus and other pathogen detection;

[0018] Step b: Disinfect and test the umbilical cord blood in the case of natural delivery, and store it in a thermostat at 2-8°C for 24 hours or store it at -23°C for 48 hours;

[0019] Step c: Collect umbilical cord blood from healthy parturients with full-term pregnancy, anticoagulate with heparin 5u / ml, umbilical cord blood collection volume is 0-5ml, and separate and process within 2 hours after collection;

[0020] Step d: The umbilical cord blood is drawn immediately after delivery of the fetus, anticoagulated, and stored in the refrigerator.

Embodiment 1

[0022] The invention relates to a stem cell preparation for regulating cellular immunity. The stem cell preparation for regulating cellular immunity is composed of umbilical cord blood as a main raw material.

[0023] A method for preparing a stem cell preparation for cellular immunity regulation, comprising the following steps:

[0024] Step a: Infectious disease inspection, pregnant women should do a good physical examination before delivery, these inspections include: whether the liver function is normal, whether there is Treponema pallidum, HIV, hepatitis B virus, hepatitis C virus and other pathogen detection;

[0025] Step b: Disinfect and test the umbilical cord blood in the case of natural delivery, and store it in a thermostat at 2-8°C for 24 hours or store it at -23°C for 48 hours;

[0026] Step c: Collect umbilical cord blood from healthy parturients with full-term pregnancy, anticoagulate with heparin 5u / ml, umbilical cord blood collection volume is 0-5ml, and sepa...

Embodiment 2

[0029] In Embodiment 1, the following steps are added:

[0030] In step a, primiparas, multiparas under the age of 45 or under the age of 35, and those who are in good health are suitable. If one of the test results is positive, the collection cannot be performed.

[0031] The invention relates to a stem cell preparation for regulating cellular immunity. The stem cell preparation for regulating cellular immunity is composed of umbilical cord blood as a main raw material.

[0032] A method for preparing a stem cell preparation for cellular immunity regulation, comprising the following steps:

[0033] Step a: Infectious disease inspection, pregnant women should do a good physical examination before delivery, these inspections include: whether the liver function is normal, whether there is Treponema pallidum, HIV, hepatitis B virus, hepatitis C virus and other pathogen detection;

[0034] Step b: Disinfect and test the umbilical cord blood in the case of natural delivery, and st...

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Abstract

The invention discloses a stem cell preparation for cellular immunoregulation and a preparation method thereof. The stem cell preparation for cell immunoregulation is mainly composed of umbilical cord blood, and the preparation method comprises the following steps: a, infectious disease examination: a pregnant woman needs to conduct physical examination before delivery, and the examinations include whether the liver function is normal or not, whether treponema pallidum exists or not, and detection of pathogens such as human immunodeficiency virus, hepatitis B virus, hepatitis C virus and the like. As the most important worker for collecting umbilical cord blood, required operation is very simple, each link has strict standard reference, the stem cell preparation is truly legal, safe and convenient from collection, storage to standby application, it can be guaranteed that the stem cell preparation is safely transplanted into the body of a patient in need, and the problems that certain potential safety hazards are brought to the prepared stem cell preparation and the patient is injured due to the fact that no specific reference is provided for the specific process and the operation specification in the preparation process of the stem cell preparation are solved.

Description

technical field [0001] The invention relates to the technical field of stem cell preparations, in particular to a stem cell preparation for regulating cellular immunity and a preparation method thereof. Background technique [0002] The wide application prospect of umbilical cord blood in the stem cell treatment workflow has attracted much attention. Umbilical cord blood is originally waste, but the advancement of medical technology has made its value unprecedentedly improved. Transplantation with HLA-matched sibling umbilical cord blood stem cells has successfully treated The genetic disease Fanconi anemia, the medical community has successfully cured and improved a variety of diseases using umbilical cord blood stem cells, including: blood system diseases, immune system diseases, nervous and vascular system diseases, brain diseases, tumors, diabetes, etc. , now in children's stem cell transplantation, because there may be 1-2 HLA site mismatches, immune rejection and other...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/51A61P37/02
CPCA61K35/51A61P37/02
Inventor 韩春悦
Owner 广东善玺迦纳栗生物科技股份有限公司