Composition for preventing or treating keloid or hypertrophic scar

A technology for hypertrophic scars and keloids, which is applied in the field of keloids or compositions for the prevention or treatment of hypertrophic scars, and can solve the problems of no established methods and the like
CN112839664APending Publication Date: 2021-05-25TEGO SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
TEGO SCI
Publication Date
2021-05-25

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Abstract

The present invention relates to a pharmaceutical composition for preventing or treating a hypertrophic scar. The present inventors acknowledged that expression inhibition of thioredoxin 5, PRRC1, S100A11, galectin 1, filamin A, eukaryotic initiation factor-5A, annexin A2 and fatty acid binding proteins 5 can be a new target for relieving and treating a hypertrophic scar. According to the present invention, the treatability of a hypertrophic scar is confirmed by producing thioredoxin 5-, PRRC1-, S100A11-, galectin 1-, filamin A-, eukaryotic initiation factor-5A-, annexin A2- and FABP5-specific siRNAs. Therefore, the knockdown of the proteins or genes coding same induces cell death in a hypertrophic scar and reduces collagen expression and thus can be highly useful for scar treatment.
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Description

technical field

[0001] The present invention relates to a composition for preventing or treating keloid or hypertrophic scar. Background technique

[0002] When the deep layer of the dermis is damaged due to surgery or trauma, the collagen in the dermis that maintains the tension of the skin is overproliferated, and the thinned skin is exposed after the wound heals, leaving traces of skin recovery. scar". This is the result of wound healing, or when the function of properly regulating and inhibiting the wound healing process is impaired, the abnormal dense growth of fibrous tissue can generate hypertrophic scars (Hypertrophic scars) or keloids (Keloid). Hypertrophic scars do not extend beyond the wound and fade over time, but keloids have the difference of growing wider than the damaged area over time, invading into normal skin. For the treatment of hypertrophic scars or keloids, attempts have been made including surgery, radiation therapy, steroid therapy, occlusive dress...

Claims

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