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Application of magnolol to preparation of drug for preventing and/or treating myelitis

A technology of magnolol and myelitis, applied in the field of application of magnolol in the preparation of drugs for the prevention and/or treatment of myelitis, to achieve the effect of reducing inflammatory cell infiltration

Inactive Publication Date: 2021-06-18
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no relevant reports on the prevention and / or treatment of autoimmune encephalomyelitis with magnolol

Method used

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  • Application of magnolol to preparation of drug for preventing and/or treating myelitis
  • Application of magnolol to preparation of drug for preventing and/or treating myelitis
  • Application of magnolol to preparation of drug for preventing and/or treating myelitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The effect of embodiment 1 magnolol in experimental autoimmune encephalomyelitis (EAE)

[0026] 1. Materials and methods

[0027] 1. Experimental animals

[0028] C57BL / 6J mice (female, 8-12 weeks old) were purchased from Nanjing Institute of Biomedicine and Shanghai Slack Experimental Animal Co., Ltd. All animal experiments were approved by the Animal Ethics Committee of Fujian University of Traditional Chinese Medicine.

[0029] 2. Take the spleen of an 8-week-old C57 male mouse, grind it to a cell suspension, pass through a 200-mesh sieve, and centrifuge to remove the supernatant. After collecting the cells, remove the erythrocytes with erythrocyte lysate, add 10 times the volume of PBS to stop, and centrifuge to remove Supernatant to collect cells, 1×10 6 / well species were placed in a 96-well plate, treated with different concentrations of magnolol (purchased from Chengdu Ruisi Biotechnology Co., Ltd.), added CCK8 for 72 hours, and the absorbance was detected at...

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Abstract

The invention provides application of magnolol to preparation of a drug for preventing and / or treating myelitis. The magnolol can significantly reduce inflammatory cell infiltration in EAE model mouse spinal cord, and also significantly alleviates demyelination phenomenon. Therefore, the magnolol can be used for preparing the drug for preventing or treating autoimmune encephalomyelitis. The invention provides a novel therapeutic drug for clinical treatment of autoimmune encephalomyelitis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a new medical application of magnolol, that is, the application of magnolol in the preparation of medicines for preventing and / or treating myelitis. Background technique [0002] Magnolol (Magnolol) is the main active ingredient of Chinese medicine Magnolia officinalis Rehd.Et Wils. Its chemical structural formula is as shown in formula (I), molecular formula: C 18 h 18 o 2 , molecular weight: 266.33, CAS number: 528-43-8, MDL number: MFCD00016658, RTECS number: DV5105500. Magnolol has antioxidant, neuroprotective, antidepressant and antitumor effects. Its isomer honokiol is currently used as an anti-glioma drug (approval number: 2016L05330) and a drug for the treatment of advanced non-small cell lung cancer (registration number: CTR20170822). It has good drug development potential. [0003] [0004] Myelitis is an inflammatory lesion of the gray matt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P31/00A61P29/00A61P37/00
CPCA61K31/05A61P31/00A61P29/00A61P37/00
Inventor 陈剑钰张俊平郑燕芳徐伟褚克丹南丽红
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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