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Ocular surface in-situ drug and preparation method thereof

A drug and ocular surface technology, applied in the field of ocular surface in-situ drugs and their preparation, can solve problems such as inability to form hydrogels, and achieve the effects of prolonging drug release time, improving cell survival rate, and promoting repair

Pending Publication Date: 2021-06-29
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, pure HA cannot form hydrogels

Method used

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  • Ocular surface in-situ drug and preparation method thereof
  • Ocular surface in-situ drug and preparation method thereof
  • Ocular surface in-situ drug and preparation method thereof

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preparation example Construction

[0047] A preparation method of the ocular surface in situ drug, comprising the steps of:

[0048] (1) Dissolve Pluronic F127, Pluronic F68 and HA-MA in isotonic solvents respectively, and dissolve photoinitiator Irgacure 2959 in deionized water;

[0049] (2) Mix the solutions in step (1) in proportion, add active drugs or nano drug-loaded microspheres encapsulating active drugs, and cross-link under ultraviolet light to obtain a temperature-sensitive hydrogel system.

[0050] The solvent is sterile PBS phosphate buffer saline or sterile physiological saline.

[0051] In a preferred embodiment, it also includes preparing the HA-MA before step (1), specifically including: adding 3 equivalents of methacrylic anhydride (MA) dropwise to 1 wt% sodium hyaluronate (HA) aqueous solution at room temperature In the first 3-4 hours of the reaction, adjust the pH to 7.5-8.5 with NaOH. After the solution was reacted overnight at room temperature, the pH was adjusted to neutral; followed b...

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Abstract

The invention relates to an ocular surface in-situ drug and a preparation method thereof. The ocular surface in-situ drug comprises a hydrogel system which takes PluronicF127, PluronicF68 and methacrylic acid-hyaluronic acid (HA-MA) as main components and has a temperature response characteristic, and a nano drug-loaded microsphere which contains an active drug or wraps the active drug, in-situ gel is formed at the ocular surface temperature, and the drug release time is prolonged. By combining the hyaluronic acid derivative HA-MA with high biocompatibility and low cytotoxicity, a brand-new temperature-triggered hydrogel sustained-release system formula for eyes is provided, so that drug sustained release on the ocular surface is realized, and the treatment on bacterial / fungal keratitis and conjunctivitis is achieved; and meanwhile, the toxicity of the material is reduced, and the repair of corneal cells can be promoted during treatment.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an ocular surface in-situ medicine and a preparation method thereof. Background technique [0002] Bacterial keratitis and fungal keratitis are one of the common diseases in ophthalmology clinics. They are corneal infectious diseases caused by bacterial or fungal infections. They are ophthalmic emergencies and endanger patients. Risk to vision. With the change of people's lifestyle and living environment and the widespread use of contact lenses, the incidence of such corneal infections has shown an increasing trend year by year. At present, worldwide, the incidence of corneal infection and ulcer in developing countries is higher than that in developed countries, and bacterial and fungal corneal infections have become the most common causes of corneal blindness. [0003] The human eye has a very complex multi-level protective structure to prevent it from being stimulat...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/10A61K47/36A61K9/52A61K45/00A61K45/06A61K31/5383A61K31/7048A61P27/02A61P31/04A61P31/10A61P29/00
CPCA61K9/06A61K9/0048A61K47/10A61K47/36A61K9/5036A61K45/00A61K45/06A61K31/5383A61K31/7048A61P27/02A61P31/04A61P31/10A61P29/00
Inventor 弥胜利王安阳
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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