Microfluidic device for efficiently separating particles in viscoelastic fluid

Abstract

The invention belongs to the field of particle separation, and discloses a microfluidic device for efficiently separating particles in viscoelastic fluid, which comprises a cover plate layer and a slide glass arranged at the bottom end of the cover plate layer, a blind sidewalk is formed in the end face of the bottom end of the cover plate layer, the blind sidewalk comprises a liquid adding area, a micro-nano particle enrichment channel, a first expansion area and a second expansion area which are sequentially communicated, and a plurality of micro-nano particle collection areas are arranged at the end, away from the first expansion area, of the second expansion area; a structural body is further arranged on the bottom end face of the cover sheet layer, one end of the structural body is located in the first expansion area, the other end is located in the second expansion area, and the surface of the structural body is connected with the surface of the slide glass; a plurality of through holes which are respectively communicated with the liquid adding area and the plurality of micro-nano particle collecting areas are formed in the cover plate layer. The device has the advantages of short channel length, high separation efficiency, no pollution, convenience in operation, simple structure, low cost, convenience in carrying, easiness in integration and the like, and effectively solves the problems of long channel length and low separation efficiency.

Description

technical field [0001] The invention belongs to the field of particle separation, and relates to a microfluidic device for efficient particle separation in viscoelastic fluids. Background technique [0002] Viscoelastic fluids widely exist in nature, such as plasma is a typical viscoelastic fluid. Because of the existence of macromolecules inside, viscoelastic fluids exhibit significantly different fluid properties from Newtonian fluids. For example, particles in microchannel viscoelastic fluids will migrate laterally due to elastic lift. Blood is a biological sample that often needs to be processed in the field of biomedicine. The micro-nano particles contained in it, such as various cells and exosomes, are important indicators for health monitoring and disease diagnosis. The high-efficiency separation has important applications in the field of biomedicine, such as the high-efficiency separation of blood cells of different sizes in blood, which helps to achieve effective m...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the existing microfluidic devices used for particle separation in viscoelastic fluids in the above-mentioned prior art. The shortcoming of achieving efficient and complete separation of particles of different sizes within a short channel length provides a microfluidic device for efficient separation of particles in viscoelastic fluids

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